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This is the first course of a two-semester chemistry program that provides teachers with everyday experiences that are directly related to fundamental chemical concepts. As such, it emphasizes the need to make careful observations, collect data, formulate conclusions and make predictions based on those findings. Teachers gain knowledge and skills by observing local chemical phenomena that allow them to then examine more complex chemical systems like global warming, ozone depletion, and the greenhouse effect; air and water quality; ecosystems; environmental factors in evolution and biodiversity; the earth, and the food web. Inherent in this process is an exposure to modeling, both developing and using physical and mathematical models to describe observed chemical phenomena. Teachers will practice inquiry methods, enhance their critical thinking skills and learn to use a variety of technical and laboratory skills to design, perform and interpret experiments
Designed to provide graduate students and senior undergraduate students with an understandingof the principles and the theory of analytical measurements and instrumentation. The course isdivided into three sections consisting of a) analytical measurements including potentiometry andvoltammetry, b) spectrophotometric measurements (i.e. molecular spectrometry), and c) ionicequilibria and statistics. This course is required for graduate programs in Analytical Chemistryand Environmental Studies (Ph.D.) and is recommended for students in other graduate programssuch as Biology, Biochemistry and Environmental Studies (MS) and other areas of chemistry.
There is currently no description available for this course.
The course is designed to provide an advanced understanding of the principles controlling structure/reactivity and the experimental techniques used to elucidate the mechanisms of modern organic reactions. The material covered includes; advanced molecular orbital theory applied to bonding and reactivity, stereoelectronic and conformational effects, intermolecular interactions, potential energy surfaces, reaction kinetics, catalytic methods, pericyclic reactivity, and protochemistry. An introduction to the application of computational chemistry to these topics will also be covered.
Mechanism, scope and limitations of important selected types of reactions and design of synthetic sequences. Emphasis is placed on methodology of synthesis and current literature.
Coverage includes the components, theory and performance of chromatographic separations including packed and capillary gas chromatography (GC) and high performance liquid chromatography (HPLC). Modern injectors, detectors, pumping systems, and other hardware used in chromatography are also discussed in detail.
Extension of introductory physical chemistry. Open to undergraduates and graduate
students in chemistry and related fields. Emphasis is placed on classical and statistical thermodynamics; surface and colloid chemistry; and electronic and vibration-rotation spectra.
This course will start with the basics of Quantum Mechanics and Quantum Chemistry followed by use of the molecular modeling software GAUSSIAN. Topics to be covered include: Schrodinger equation and wave functions; Particle in a box; Particle in a ring; Heisenberg uncertainty principle; QM operators, Eigenvalue problem; Eigenvectors & eigenvalues; Hermitian operators and commutators; Harmonic oscillator & IR spectroscopy; Rigid Rotator & Rotational Spectroscopy; H-atom, H2+ion; using Mathematics to solve QM problems (e.g. atomic/molecular orbitals visualization), He-atom and variational method; Electron spin and Pauli exclusion principle; EPR/NMR; Semiempirical methods; Many-electron systems; Slater Determinants, Hartree and Hartree-Fock methods; Diatomic molecules; Born-Oppenheimer approx.
Discussion of various biochemical reactions from the point of view of organic reaction mechanisms. Kinetics, coenzymes and methods of the study of enzyme and catalysis and mechanisms are emphasized.
A theoretical treatment of atomic structure and chemical bonds, included are such topics as Russell Saunders' coupling, molecular orbital theory, ligand field theory, and descriptive coordination chemistry.
An advanced study of the structure and properties of proteins, nucleic acids, carbohydrates and lipids, including kinetics and mechanisms of enzyme action and detailed description of metabolic pathways of carbohydrates and lipids.
A continuation of 84.550 with emphasis on metabolic pathways of amino acids and nucleic acid, biosynthesis of proteins and selected topics in molecular biology and various areas of biochemistry.
Physical chemistry encompasses a group of principles and methods helpful in solving many different types of problems. This course will present selected principles of thermodynamics,kinetics, statistical thermodynamics and quantum mechanics as they are applied to biochemicalsystems. Various experimental techniques will be strongly emphasized in view of their importancein biochemical research.
Pharmaceutical Biochemistry examines the biochemical and molecular mechanisms of drug interaction. Topics include basic aspects of molecular complementarity (molecular recognition), specificity and stability of ligand binding (energetic), as well as crystallographic and computational approaches.
Pre-Req: CHEM.5500 Biochemistry I
Covers the proof of structure of various types of natural products, approaches to the total synthesis of these products and the biosynthetic pathways.
Nanoscience and nanotechnology focus on the understanding and control of matter at the dimension of 1-100 nanometers, i.e., the nanoscale. Nanoscale structures, materials and devices have unique properties and functions solely because of their sizes. Research and technology development in nanoscience and nanotechnology aim at understanding the fundamental nanoscale phenomena, synthesizing, fabricating and imaging nanomaterials and nanostructures, and constructing nanoscale systems that offer unprecedented properties and functions. In this course, we will discuss the fundamental nanoscale phenomena. We will learn variety of nanomaterial characterization techniques including scanning probe, electron probe, absorption and particle spectroscopies. Fabrication processes of top-down and bottom-up approaches will be discussed, including molecular and material self-assembly. We will study surface phenomena and surface energy that are of critical importance for nanomaterials and nanostructures. We will also learn various ways to control the structures and properties of nanomaterials and surfaces. A variety of nanomaterials and nanostructures will be discussed, including metal, semiconductor, organic and inorganic nanoparticles, carbon nanomaterials, and various natural and synthetic nanostructured surfaces. Applications of these nanomaterials in nanomedicine and theranostics will also be discussed.
Pre-Req: 84.222 Organic Chemistry IIA.
This course will provide and introductory survey of the basis of theory/simulations of biomolecules. It is accessible to anyone who has completed two semesters of undergraduate chemistry and who has some background in physical chemistry. Topics/examples will be borrowed from modern biological chemistry and biophysics of single biomolecules. The course will be useful for senior undergraduates and beginning graduate students. Chem/Bioinformatics 84.567 will attempt to cultivate computational skills, which on needs to tackle current scientific problems of biology and biophysics.
Practical applications of instrumental data in the determination of the structure of organic compounds and polymers. Includes mass spectrometry, ultra-violet spectroscopy, infrared spectroscopy and nuclear magnetic resonance spectroscopy. Open to undergraduate students with permission.
This course outlines the assembly process, structural and functional attributes of protein. Special attention will be given to three-dimensional structures, folding, post translational modifications, misfolding and degradations, as well as biochemical and biophysical techniques used to elucidate protein structure and function.
Analytical biochemistry involves the separation, detection, and analysis of biological molecules. This course addresses advanced theory and applications of contempory biochemical techniques and instrumentation. Topics covered include chromatographic and electrophoretic separation techniques, detection of biomolecules by spectroscopy and radiochemical methods, biological preparations, and structural analysis of proteins, nucleic acids, polysaccharides and lipids.
Pre or Co-Req: 84.550 Biochemistry I.
This course aims to provide deepened and widened knowledge of concepts, reactivity, and synthesis in modern organic chemistry. It encompasses: main group chemistry, carbonyl/enol/enolate chemistry, heterocyclic compounds, fragmentations, rearrangements, frontier molecular orbital theory, pericyclic reactions, reactive intermediates, organometallic chemistry, selective synthesis, stereochemistry, catalysis, asymmetric synthesis, and multi-step synthesis.
Supramolecular chemistry can be described as 'chemistry beyond the molecule' and involves the study of complex structures held together by weaker interactions. In general, non-covalent bond types, such as electrostatic interactions, van der Waals' forces, hydrogen bonds, and metal coordination, are used, but reversible covalent bonds can also be included. This course will provide detailed understanding of the general principles and concepts of the field, including host-guest chemistry, molecular recognition, and self-assembly, as well as highlight a wide variety of examples and applications of supramolecular systems in chemistry, biology, nanotechnology, and materials science.
Pre-Req: CHEM.2210 Organic Chemistry I, CHEM.2220 Organic Chemistry IIA.
Required of all graduate students. Presentation of current topics by graduate students.
Required of all graduate students. Presentation of current topics by visiting scientists and staff.
This course teaches fundamental principles of drug development, including small organic compounds and biologics. Key aspects of their synthesis, physical characteristics, and pharmaceutical properties are discussed. Topics covered include discovery strategies, statistic-based modeling (e.g.,QSAR), structure-based and mechanism-based design methods, and combinatorial techniques.
Pre-req: CHEM.5500 Biochemistry I.
The mechanisms of prototypical drug classes are discussed, including structure-property relationships. Computational methods and means of visualizing drug-substrate interactions at the molecular level are emphasized. Drug design and function are integrated with relevant topics in related disciplines, including biochemistry, biology and physiology.
Pre-req: CHEM 6310 Principles of Medicinal Chemistry l and Co-req: CHEM 5510 Biochemistry ll. Note: that CHEM 5510 (Biochemistry ll) could be taken prior to this course instead of concurrently.
Practical training for International Students in a Co-operative agreement with Industry or a Government Laboratory for 1 semester.
Advanced topics in various fields of chemistry. Content may vary from year to year so that students may, by repeated enrollment, acquire a broad knowledge of contemporary chemistry.
Surface and colloid chemistry describes the nanoscopic and mesoscopic regimes that connect molecular and macroscopic length scales. The course focuses on how phenomena at macroscopic surfaces and interfaces arise from molecular interactions. Intermolecular and surface forces discussed in detail include van der Waals and electrostatic forces, and how these together with steric interactions give rise to different molecular aggregates (self-assembled structures of surface active molecules and polymers) in bulk solution and in the vicinity of solid surfaces. Examples of modern experimental techniques for measurements of surface forces and for characterization of surfaces and aggregates are discussed and demonstrated.
Continued research project supplementing the research credits for a doctoral student. This course will require special permission from the Graduate Coordinator.
Master's Thesis - Chemistry
A study of the principles of condensation, free radical, ionic, coordination and ring opening polymerization. The topics include the effect of polymerization techniques on reaction kinetics and molecular weight, and the evaluation of reactivity ratios in copolymerization reactions.
Introduction to chain statistics and thermodynamics of macromolecular solutions, methods of study of molecular weight and chain conformation, and the properties of polymers in bulk including viscoelasticity and crystallinity.
Topics include conformation and configuration of vinyl polymers and polypeptides, energetics of chain folding and examination of the forces dictating ordered structures, helix to coil transitions in biopolymers with emphasis on polypeptide structures, instrumental analysis of biopolymer conformation, synthesis of biopolymers including polypeptides, polysaccarides and polynucleotides, and examination of relationships between synthetic polymers and naturally occurring polymers.
An advanced study in polymer science concerned with the synthesis of macromolecules and their mechanisms of formation.
Required of all Polymer Science graduate students. Presentation of current topics in polymer science by graduate students.
Required of all Polymer Science graduate students. Presentation of current topics in polymer science by visiting scientists and staff.
This course is an introduction to the fundamental science and potential applications of conjugated polymers in optical and electronic technologies. The topics covered include history, synthesis and molecular structure, including solid state polymerization; crystallinity and morpholgy, including assembly methods; electronic structure including energy bands, conjugation defects and photoelectron spectroscopy; properties of the insulating forms including light absorption and emission, thermochromism, carrier transport, electroluminescence and nonlinear optical properties; properties of the conducting forms, including ""doping""; some specific devices.
This is a one credit thesis review course.