All courses, arranged by program, are listed in the catalog. If you cannot locate a specific course, try the Advanced Search. Current class schedules, with posted days and times, can be found on the NOW/Student Dashboard or by logging in to SiS.
Introduces topics such as the chemical and physical basis of life, its evolution, diversity, distribution, and interrelationships of life forms. The central theme of genetic replication, translation, expression, and selection will be emphasized as a unifying principle which determines and integrates structure and function at the cellular, individual population, and community levels of organization. Designed for those students who intend to pursue career options in the biological sciences, biotechnology or related areas such as medicine, biomedical research, radiological sciences or environmental sciences. It is the first-semester course of a two-semester sequence.
Co-Req: BIOL.1170L Experimental Biology I and Anti-Req: BIOL.1220 and BIOL.2100 and LIFE.1000 and LIFE.1010.
Serves as a continuation of the 81.111/81.112 sequence for those students who intend to pursue career options in the biological sciences or related professional areas such as medicine, biomedical research or environmental sciences. Molecular energy exchange in organisms (photosynthesis and respiratory metabolism), the common functional needs of support, locomotion, nutrition, internal communication and the maintenance of homeostasis are considered. Control and regulation of organisms at levels beyond the individual are considered through discussions of population and community ecology.
Co-Req: BIOL.1180L Experimental Biology II.
Presents a series of field trips and laboratory exercises designed to introduce the student to concepts of the distribution and maintenance of life. Specific consideration is given to the diversity and organization of local ecosystems; the continuation of life is considered through exercises covering mitosis, meiosis, genetics, and evolutionary biology.
Provides laboratory experiments, analyses, and dissections designed to introduce the student to biological techniques and processes at the sub-cellular, cellular, and organ systems levels.
Co-Req: BIOL.1120 Principles of Biology II.
This course is designed to acclimate incoming students to their new University environment. Students will learn about the Biology program, its faculty and staff members, University resources, and other information useful for success.
A laboratory course covering introduction to scientific inquiry in the biological sciences for majors in biology and related fields. Techniques that are important in biology (ex: microscopy, spectrophotometry and pipetting) are taught and these techniques are applied to the investigation of biological principles emphasizing basic cell and molecular biology, metabolism and fundamental processes of life.
Co-Req: BIOL.1110 Principles of Biology I.
A laboratory course covering introduction to scientific inquiry in the biological sciences for majors in biology and related fields. Techniques that are important in biology (ex: microscopy, dissection) are taught and these techniques are applied to the investigation of basic biological principles emphasizing plant and animal diversity and organ systems.
Develops a basic understanding of biological topics relevant to students in the health sciences. Course will introduce students to biochemistry, cell biology, cellular respiration, cell replication, genetics, inheritance and molecular biology. Introduction to prions, viruses, prokaryotic and eukaryotic biology will also be covered.
Co-req: BIOL.1240 Biology for Health Sciences Lab, and Exercise Physiology Majors Only or Exercise Science Majors; Anti-Req: BIOL.1110 and BIOL.2100 and LIFE.1000 and LIFE.1010.BIOL.1240 Co-req & EP Majors.
Develops a basic understanding of biological topics relevant to students in the health sciences. Course will introduce students to biochemistry, cell biology, cellular respiration, cell replication, genetics, inheritance and molecular biology, Introduction to prions, viruses, prokayotic and eukaryotic biology will also be covered.
Co-Req: BIOL.1220 Biology for Health Sciences.
Curricula Practical Training. "Variable credit course, student chooses appropriate amount of credits when registering."
A study of the general properties of bacteria and viruses (anatomy, physiology, genetics,metabolism, cultivation, and growth); discussions include major microbial infections in man (etiologic agent, antibiotics and chemotherapy) and an examination of the role of the microbes in the environment.
Pre-Reqs: BIOL 1110 Principles of Biology I, BIOL 1120 Principles of Biology II.
A series of laboratory exercises covering basic qualitative and quantitative techniques commonly employed in a microbiology laboratory.
Co-Req: 81.201 General Microbiology.
An introduction to the field of bioinformatics with some hands-on exploration of applications. Specific areas include scientific archives and information retrieval, genome organization and evolution, phylogenetic analysis, comparative genomics, transcriptomics, proteomics, structural bioinformatics, and systems biology. In addition to covering the biological principles underpinning the bioinformatic approaches to study the biology and evolution of genomes and systems, this course also imparts basic computational skills in data retrieval from databases in molecular, functional, and structural biology.
Develops a basic understanding of the science of biology for engineering students, including and introduction to biochemistry, cell biology, metabolism, genetics, genomics, molecular biology, cell growth, and nutrition. Both eukaryotic and prokaryotic biology will be covered.
Co-req: BIOL.2120L Biology for Engineer Lab, and Biomedical Engineering, or Chemical Engiineering, or Environmental Engineering Majors only. Anti-req: BIOL.1110, and BIOL.1220, and LIFE.1000, and LIFE.1010.
This laboratory course will build on BIOL.2100. It will provide an introduction to several basic biological techniques and approaches used in biological engineering laboratories.
Co-req: BIOL.2100 Biology for Engineers.
This course will cove basic topics in cell and molecular biology, including structures of proteins, lipids, carbohydrates and nucleic acids, structure of DNA and it replication and repair, transcription, and cell-cell communication. The molecular biology of cells and the regulation of cellular processes will be emphasized.
Pre-req: C- or better in BIOL-1110 Principles of Biology l, or Spring 2020 grade of "P".
This is a project-based course designed to introduce students to the methods of general biological laboratory research. Techniques will be introduced in the context of interrelated experiments during a semester-long project. Techniques will include, but are not limited to: making solutions, pipetting, using sterile technique, gel electrophoresis, DNA transformations, minipreps, and other molecular and microscopic methods.
Pre-req: BIOL.1110 Principles of Biology I, and BIOL.1170L Principles of Biology I Lab, and BIOL.1120 Principles of Biology II, and BIOL.1180L Principles of Biology II Lab. With a C- or better in BIOL.1110.
The theories of both classical and molecular genetics are explored with emphasis on the experimental evidence which has laid the foundation for contemporary understanding of genetics, included is the nature of the genetic material, gene action, genetic recombination, gene regulation, gene interaction, the production and inheritance of genetic phenotypes, chromosomal mechanics, and the behavior of genes in populations.
Pre-req: BIOL.1110 Principles of Biology l, with a grade of C- or better, or Spring 2020 grade of "P".
Over 5 million species thrive in amazingly diverse habitats on Earth ranging from the extreme freezing cold of the poles to the lush warmth of the tropics. How did this fantastic diversity arise on our earth? How are these species intimately interconnected with one another, their communities and their ecosystem? How can we save this remarkable biodiversity from extinction? This course will address these key questions by examining the fundamental concepts of evolution, ecology and conservation biology. Students will be expected to attend a discussion section in which they will examine case studies and primary scientific literature.
Pre-req: C- or better in both BIOL.1110 Principles of Biology l, and BIOL.1120 Principles of Biology ll, or Spring 2020 grade of "P".
Presents a comprehensive study of the fundamental mechanisms governing mammalian physiology. The role of cell physiology in determining systemic functions and coordinating biological control systems will be emphasized. Maintenance of homeostasis will be discussed in terms of biochemical, cytological, anatomical, and physical principles.
There is currently no description available for this course.
General properties of bacteria and viruses including anatomy, physiology, genetics, metabolism, cultivation, growth, control and their role in the ecosystems, and industry.
Pre-Reqs: BIOL.1110/1120 Principles of Biology I & II and CHEM.1210 Chemistry I or CHEM.1220 Chemistry II or CHEM.1350 Honors Chemistry.
A series of laboratory exercises covering basic qualitative and quantitative techniques commonly employed in a microbiology laboratory including sterile technique, microscopy, enrichment and isolation, and prevention.
Co-Req: 81.301 Microbiology
An introduction to the field of bioinformatics with some hands-on exploration of applications. Specific areas include scientific archives and information retrieval, genome organization, comparative genomics, transcriptomics, proteomics, structural bioinformatics, and systems biology. This course also imparts basic computational skills in data retrieval from the databases in molecular and structural biology.
A survey of the phyla of invertebrate animals. Discussions include their physiology, development, morphology, behavior, ecology and adaptations. Corequisite: 81.308
A broad spectrum of living and preserved specimens are studied in the laboratory with regard to both structure and function. Corequisite 81.306
Co-req: BIOL.3060 Invertebrate Zoology.
A series of lectures concerned with the interrelationships of organisms with their abiotic environment with emphasis on the New England area. Selected current topics will supplement the text.
Pre-req: BIOL.2400 Evolution, Ecology and Conservation, and Co-req: BIOL.3170L Principles of Ecology Lab, or Permission of Instructor.
A series of laboratory exercises to supplement and illustrate lectures of 81.315. Field trips are an integral part of the course involving sampling and analysis of such ecosystem components as water, soil, invertebrate fauna and characteristic flora of various habitats. Directed readings, quizzes, practical exam and oral presentation of a research topic are integral parts of the course.
Co-Req: BIOL.3150 Principles of Ecology.
Serves as an introduction to the study of the plant kingdom dealing with the structure, function, and diversity of plants with an emphasis on seed plants. The physiology, morphology, and taxonomy of plants is emphasized.
Emphasizes material covered in 81.320 using field and laboratory exercises.
Co-Req: 81.320 Botany.
Discussions on how humans use plants. Topics will include: Structure and characteristics of woods and their uses in construction of various items, agricultural uses of food plants and spices, poisonous plants, medicinal plants, plants used in religious ritual and plants used as hallucinogens, plants that have altered human history.
Pre-req: BIOL 1110 Principles of Biology I, or LIFE 1010 Life Science I.
This course is designed to provide students a broad understanding of the anatomy of vertebrates with an emphasis on comparison between taxa and their evolutionary significance. Students will acquire knowledge and understanding of anatomical structure and terminology of vertebrates and an understanding of how these structures have evolved from ancestral forms. There will also be some reference to the fields of embryology, histology and paleontology in the course.
This course may interest students who might want to go into various animal/human focused fields (e.g. veterinary science, medicine or graduate studies with more organismal focus), and students who simply want a course focused on vertebrates. However, students should note that this course does not focus on human nor veterinary anatomy.This course could also help undergraduates in the General Biology and Ecology Option satisfy free elective requirements.
Pre-req: BIOL.1110 Principles of Biology I, and BIOL.1120 Principles of Biology II, and Co-req: BIOL.3440L Comp. Vertebrate Anatomy Lab.
Pre-req: BIOL1110 Principles of Biology I, and BIOL.1120 Principles of Biology II, and Co-req: BIOL.3420 Comp Vertebrate Anatomy.
Many of our childhood biology lessons entail examples of plant-animal interactions, with macro-level examples that included bees pollinating flowers, squirrels burying acorns in the Fall and caterpillars eating holes in leaves. Yet there are many less obvious ways that plants and animals interact in our biosphere; this course will attempt to provide an overview of major themes in this field. We will delve into the evolutionary origins of how these relationships began and examine how these ecological interactions seem to sustain all biodiversity of Earth. By end of the course, students will be well versed in the technical jargon used in the field and will appreciate the importance of inter-species interactions between the animal and plant kingdom for evolutionary innovation and diversity.
Pre-req: BIOL.2400 Evolution, Ecology and Conservation, and BIOL.2350 Genetics.
This course will introduce the concepts and methods of the field of evolutionary developmental biology. We will cover gene regulation and evolution. Through primary literature, discussion and presentation, we will explore how genetic changes to developmental processes contribute to evolutionary change.
Pre-req: BIOL.2200 Principles of Cell and Molecular Biology, and BIOL.2400 Evolution, Ecology and Conservation.
Through observation, preparation of material and presentation of demonstrations in selected courses offered by the Department of Biological Sciences, the student becomes familiar with the materials and teaching/learning situations in biology.
There is a growing need for bioinformaticians in research and industry as datasets are getting bigger and complex, making computational methods necessary for analysis. This hands-on course introduces principles, databases, software, and programming for the analysis and interpretation of molecular datasets. Emphasis is on practical assignments using computational approaches from a biologist's perspective. Topics include genome assembly, variant detection, comparative genomics and transcriptomics, metagenomics, as well as data retrieval from databases and basic programming using Bash and R. A term project and computer-based exercises are designed to showcase the capabilities and limitations of bioinformatics tools used in genome research, as well as to develop skills in coding literacy.
Pre-req: BIOL.2350 Genetics.
This hands-on course introduces databases, approaches, and software for the analysis and interpretation of molecular sequences. Practical assignments and a term project emphasize the application of computational approaches from a biologist's perspective. Topics include genome assembly, transcriptomic analysis, and data retrieval from databases using both graphical user interfaces and basic computer programming using Bash and R. The class assignments are all computer-based exercises that are designed to showcase the capabilities and limitations of bioinformatics research and tools used in sequence analysis, as well as to develop skills in coding literacy.
Pre-req: BIOL.2350 Genetics, and Co-req: BIOL.4062L Bioinformatic Tools Lab, Must take both BIOL.4062 Lecture and BIOL.4062L Lab together.
This lab accompanies the lecture, with hands-on practical assignments to achieve a firmer understanding of bioinformatics tools and principles. Assignments and a term project emphasize the application of computational approaches from a biologist's perspective. Topics include genome assembly, transcriptomic analysis, and data retrieval from databases using both graphical user interfaces and basic computer programming using Bash and R. The class assignments are all computer-based exercises that are designed to showcase the capabilities and limitations of bioinformatics research and tools used in sequence analysis, as well as to develop skills in coding literacy.
Pre-req: BIOL.2350 Genetics, and Co-req: BIOL.4062 Bioinformatics Tools Lecture, Must take both BIOL.4062 lecture and BIOL.4062L Lab together.
Like many other areas of science and business, biology in increasingly defined by increasing amounts of available data. The ability to analyze, visualize, and make inferences from this data will become increasingly valuable for future biologists. Data science can be defined as the intersection between computer science, applied statistics, and knowledge of the application domain--in this case, biology. In this class we will apply methods such as generalized linear models, multi-level models, unsupervised learning, and basic neural networks to biological problems. Hands-on activities using programming will give students experience with steps of a data science project, including simulating, exploring, visualizing, drawing conclusions with statistics, and creating a reproducible analysis.
Co-req: BIOL.4072L Data Science for Biologists, and Pre-req: BIOL.2220, or COMP.2010, or MATH.2340, or MATH.2360, or MATH.3220, or Permission of Instructor.
Each week we will focus on a different set of data science skills with a one-day project done in small teams. Hands-on activities using data science programming languages will give students experience with steps of a data science project, including simulating, exploring, visualizing, drawing conclusions with statistics, and creating a reproducible analysis.
Co-req: BIOL.4072 Data Science for Biologists.
Biological process involving light in plants and animals. Topics include mechanisms of light absorption, energy transduction, light reactions in photosynthesis, functions of color in flowering plants, visual systems and structural and pigment coloration in animals, pigmentation in animals affecting camouflage and reproductive strategies. In addition, the genetics involved in responses to light such as photoperiods, cicardian rhythms, and seasonal cycles will be covered.
Pre-Req: BIOL.4190 Biochemistry.
An individual, directed one-year research program for senior biology majors selected on the basis of previous academic performance at the end of the junior year. A topic will be chosen after consultation with a faculty member. A report of the research in the form of a thesis is required.
Studies the structure and properties of proteins, carbohydrates, and lipids which combined with a discussion of elementary enzymology allows for detailed descriptions of several important degradative and biosynthetic pathways, their integration and regulation. Throughout the course, emphasis is on methods and practical application of fundamental information to the solution of problems of current biomedical interest.
Pre-req CHEM 2220 Organic Chemistry II or CHEM 2230 Organic Chemistry IIB and BIOL 2200 Principles of Cell and Molecular Biology or BIOL 2350 Genetics or BIOL 2120L Biology for Engineers.
This course will focus on protein dynamics where students will gain facility with thermodynamics of protein folding/misfolding, catalysis, kinetics and binding equilibria as they apply to proteins and other molecules in biological systems. The central theme of this course is that living systems can be understood in terms of the fundamental principles defining the structure and energetics of biological molecules. Attention will be given to quantitative aspects of enzyme kinetics and molecular binding. Examples of how these principles apply to the understanding and treatment of human disease will be discussed.
A series of discussions and "hands on" laboratory exercises emphasizing techniques and use of equipment most commonly employed in biochemicaI-biomedicaI research laboratories. Techniques to be mastered include: cell culture, cell fractionation, enzyme purification, ultracentrifugation, UV-visible spectrophotometry, spectrofluorometry, various types of chromatography (thin layer, gas, gel exclusion, ion exchange), electrophoresis, liquid scintillation spectrometry, and the safe handling and application of radioisotopes to problems in biochemistry. Wherever possible, the principles presented in 81.419 will be used as a basis for experimentation using the above techniques. Meets Core Curriculum Essential Learning Outcome for Written & Oral Communication (WOC).
Pre-req: CHEM.2300L Organic Chem Lab IIB, or CHEM.2280L Organic Chem Lab IIA, and BIOL.2330L Experimental Methods in Biology.
This seminar course will focus on the detailed discussion of the structure of proteins and other biological molecules and how the structure determines the function of those molecules.
Pre-req: BIOL.4190 Biochemistry with a C- or better.
An examination of the role of life processes in controlling the cycling of elements on the surface of the Earth and atmosphere from the molecular to the global level. Students will learn how the different physical components of Earth interact, how these interactions are influenced by life, and how they affect Earth's habitability now and in the future.
Pre-Req: BIOL.1120 Principles of Biology II.
Examines the patterns and processes of biological evolution that have led to the diversity of life. Topics covered include the history of evolutionary thought, the evidence for evolution, the generation and maintenance of population-level variation, natural selection, adaptation, sexual selection, speciation, phylogenetics, molecular evolution, the fossil record and extinctions. In addition to lecture and textbook material, students will read and discuss classic and contemporary primary literature from evolutionary biology.
Pre-req: BIOL.2400 Evolution, Ecology and Conservation, or permission of instructor.
Proteins are major targets of pharmaceuticals, and are themselves increasingly used as therapeuticals. However both basic research and the pharmaceutical industry depends on availability of purified proteins that are often difficult to isolate from native sources. In this lecture course, students will learn basic and advanced theoretical background in expression and purification of recombinant proteins. It will cover a variety of expression systems including prokaryotic and eukaryotic cells. The course will also address traditional and new methods in recombinant protein purification. Furthermore, students will be introduced to some downstream applications such as crystallization screens and biochemical/biophysical studies.
Pre-req: 81.111 Principles of Biology I.
This course introduces students to the principles and practice of recombinant protein expression and purification's. Proteins are major targets of pharmaceuticals, and are themselves increasingly used as therapeuticals. However both basic research and pharmaceutical industry depends on availability of purified proteins that are often difficult to isolate from native sources. This course will provide both didactic and laboratory instruction. It is comprised of a series of lecture and laboratory exercises, with an emphasis on practical techniques and hands-on experience of recombinant protein purification. The course will cover a variety of expression systems, including prokaryotic and eukaryotic cells, and address traditional and new methods in protein purification.
Pre-req: BIOL 2330L Experimental Methods in Biology, or BIOL 4210L Biochemistry Techniques.
Cancer is usually the result of genetic alterations acquired over a lifetime that enable a tumor to grow and spread. As a result, each tumor is unique and involves a complex combination of mutations--a part of the reason that cancers can be so hard to treat. To better understand the characteristics of these diseases and discover appropriate treatments, institutions have comprehensively profiled the genomic changes across thousands of people's tumors. That data is available for anyone with the right skills to analyze. In this class, we will delve into the genomics of cancer, as a way to learn how cancers develop, how molecular profiling technologies generate data about these cancers, and how bioinformatics approaches can harness these data to gain insight and discover treatments.
This course surveys the field of genomics, examining current technologies and their biological applications. Lectures cover genome organization, genome sequencing and annotation, functional genomics, evolutionary genomics, transcriptomics. proteomics and the role of bioinformatics in organizing and interpreting genomic data.
Pre-req: BIOL 2350 Genetics and Co-req: BIOL 4340L Genomics Laboratory.
A series of molecular laboratory and computer-based bioinformatics exercises providing practical experience in the collection and analysis of genomic-level data.
Pre-req: BIOL 2350 Genetics and Co-req: BIOL 4320 Genomics.
Animals learn songs, practice agriculture, and craft tools. They build elaborate structures without a blueprint and migrate across the globe without a map. This course explores the mechanistic and evolutionary causes of animal behavior, A combination of lectures, discussions, and animal demos will introduce students to major themes in the field, while emphasizing experiments and ecological context as fundamental to the study of behavior. Students will discuss historic debates and emerging research on the evolution of exaggerated sexual ornaments and defensive structures, sensory bias, heritability of behavior, reciprocity & kinship, and the emergence of animal societies. By the end of the course, students will be able to interpret the behaviors of animals in an evolutionary framework. Students from other departments, including Psychology, and Environmental Science can join this course with instructor permission.
This course will explore the fundamental concepts of field ecology. The goal of this course is to give students an immersive, research-oriented, hands-on learning experience that integrates the interactions of organisms with each other and with their abiotic environment in both aquatic and terrestrial ecosystems in Massachusetts and elsewhere in New England. Students will learn the natural history of these habitats and their organisms, engage in scientific field research, and develop sills in data collection, analysis, and interpretation. By the end of the course, students will have a working toolbox of field techniques to ask questions in population, community, and ecosystem ecology.
A detailed examination of phylum Arthropoda from developmental, ecological, genetic, morphological and paleontological perspectives. Specific topics include the relationships of arthropods to protoarthropod-like groups including tardigrades and onychophorans, the evolution of segmentation, and current perspectives on relationships within the phylum.
Pre-req: BIOL 3060 Invertebrate Zoology; BIOL 3080L Invertebrate Zoology Lab; BIOL 4260 Evolutionary Biology and Co- req: BIOL 5390L Biology and Evolution of Arthropoda Lab.
This course explores fundamental concepts in classical and molecular genetics. We will examine how studies in genetic model organisms (including budding yeast, Drosophila, and C. elegans) have yielded remarkable insight into a host of biological mechanisms, including cell-signaling pathways, animal development, and gene regulation. Special emphasis will be placed on how geneticists design and interpret their studies. The semester will cover strategies ranging from the classical (screens, selection, complementation, and conditional mutants) to the modern approaches enabled by the genomic revolution (genetic engineering, gene misexpression, and genome-wide association studies}
Pre-req: BIOL.2350 Genetics, with a grade of C- or better. Students from other departments (including Biomedical Engineering or Applied Biomedical Sciences) may enroll with instructor permission.
Although epigenetic phenomena have been observed for over a century, researchers have only started to untangle their underlying mechanism and effects on gene expression. This course provides and overview of epigenetic mechanisms, including DNA methylation, histone modifications, chromosome structure, and nuclear organization. We will discuss how molecules help regulate gene expression to affect health, development, and cell fate across organisms. The class will rely upon current and classic readings from the primary literature to best understand new genomic advances and current technological limits in the field. A special emphasis will be placed on experimental design and data interpretation.
Pre-req: Students in Biological Sciences must have passed BIOL.2350 with a grade of C-or higher. Students from other departments (including Biomedical Engineering or Applied Biomedical Sciences) may enroll with instructor permission.
An exploration of protoarthropod and arthropod diversity using live and preserved specimens of the major taxa including Tardigrada, Onychophora, Chelicerata, Crustacea, Myriapoda and Hexapoda. Students will learn to collect, dissect, identify, handle and care for live specimens.
Pre-req: BIOL 3060 Invertebrate Zoology; BIOL 3080L Invertebrate Zoology Lab, BIOL 4260 Evolutionary Biology and Co-req: BIOL 5370 Biology and Evolution of Arthropoda.
This is an advanced course in cell biology. In this course we will examine different areas of eukaryotic cell biology including: membrane structure and function, cell adhesion, intercellular communication, signal transduction, chemotaxis, receptor-mediated endocytosis and intracellular trafficking. Mechanisms underlying relevant human diseases will also be discussed. Upon completion of the course the student will have a strong understanding of cell biology, develop critical thinking processes, proficiency in scientific reading and how to communicate material succinctly.
Pre-req: BIOL.2350 Genetics, and BIOL.2200 Principles of Cell & Molecular Biology.
This course will provide you with a solid comparative knowledge of how vertebrates including humans have evolved, focusing on how anatomy (form) feeds function (physiology, biomechanics) in movement biology (Cardiorespiratory, sensing, locomotion, feeding). It is only by understanding our evolutionary history that you understand e.g. how vertebrates became Olympian movers, how humans became bipedal, why we use parts of the ancestral jaw to hear, and how we avoid choking when we swallow. Such knowledge is key for medical and veterinary school, but will also support you in biomedical and biotechnology fields as well as in various general science disciplines. This course emphasizes modes of thought, including the differences between evidence and inference, and between correlation and causalit.
Pre-req: BIOL.1110 Principles of Biology I, and BIOL.1120 Principles of Biology II, and BIOL.2400 Evolution, Ecology and Conservation.
This course takes integrative approaches to exploring architecture, physiology and mechanics of vertebrate skeletal muscle as the main driver of movements in organisms including humans. Combining presentations and discussions of important publications with simple experiments and report-writing, the course hones a specialist-level understanding of how the organ structure is constructed, how cell-level phenomena govern contraction, how the nervous system controls muscle function, how muscle contractions are constrained by physics, and how muscle as an organ structure is able to mitigate those constraints. We will also build and use actuators inspired by muscle function.
An introduction to the diversity of single-celled eukaryotes, i.e., protozoans, that are parasites of humans, domestic, and wild animals. Lectures emphasize the morphology, physiology, and life cycles of species of Plasmodium (Malaria), trypanosoma (Sleeping sickness, Chagas disease), Leishmania (Leishmaniasis), and Toxoplasma (Toxoplasmosis), and include their arthropod vectors when present (mosquitos, sand flys, kissing bugs). We will cover the basics of disease (symptoms and pathologies), treatments, and control measures. Contemporary research efforts will be emphasized.
Pre-req: BIOL.2200 Principles of Cellular Biology or a comparable transfer course.
This course instructs students in developing effective writing and speaking skills required for preparation of scientific manuscripts and presentations, and communicating in the scientific world. Students will be required to prepare and present oral presentations and to submit written reports.
This course explores the diversity, evolution, and behaviors of insects. Insects are pollinators, undertakers, and parasites. They are master architects, and the inventors of flight and agriculture. Their societies can tower over elephants or fit in the palm of your hand. Plagues of locusts have shaped human history and wars have been won on the backs of fleas. This course emphasizes comparative natural history and experimentation as the foundation of innovations in entomology. Students will develop a solid understanding of the principles of insect biology that can be applied to medical, forensic, veterinary, agricultural, conservation and academic fields.
This laboratory focuses on insect classification, development and behavior. Students will travel to local field sites to study and collect insects. Each student will curate a professional insect collection and develop a working knowledge of insect taxonomy through dissection and comparison of preserved specimens, including economically and medically important insects. Students will also rear a variety of social and solitary insects under experimental conditions and report their results. Labs on behavior will focus on insect communication, parental care, eusociality, and orientation.
Co-req: BIOL.4550 Entomology.
An introduction to the diversity of metazoans (animals) that parasitize humans, livestock, other animals (both vertebrate and invertebrate), and plants. Lectures emphasize the morphology, form and function, physiology, systematics, evolution, life cycles and pathogenesis of several major parasitic groups. Formerly: Advanced Invertebrate Zoology.
Pre-Req: BIOL 3060 Invertebrate Zoology; Co-Req: BIOL 4590L Metazoan Parasitology Laboratory.
The purpose of the laboratory is to provide students an opportunity to identify and work with a variety of parasites that we discuss in lecture. We will work with preserved specimens, slide material, necropsies, and live specimens. Students will learn how to identify parasites and understand how they affect host biology.
Co-req: BIOL.4570 Metazoan Parasitology.
The molecular and genetic characteristics of stem cells and their developmental potential will be explored. Lectures and readings will cover the development of embryonic, fetal and adult stem cells, and will examine their use in treating human disorders receiving widespread attention, including neurodegenerative diseases, heart disease, spinal cord injury and leukemia. The ethical, legal and social implications of stem cell research will also be discussed. Additional library investigation and a term paper or seminar will be required.
Pre-Req: BIOL 3350 Principles of Genetics or BIOL 2350 Genetics.
This course will focus on human cardiovascular physiology in normal and diseased states. The objective of Cardiovascular Physiology is to reinforce the concept that the cardiovascular system can be understood in terms fundamental biophysical and cellular physiological principles. Quantitative aspects will be reinforces with problem sets in the accompanying lab course 81.463. Key concepts in the course will be placed in a medical context showing the underlying physiological concepts that lead to disease states such as; altered blood pressure, heart failure, valvular disease and arrhythmias.
Pre-req: BIOL.4190 Biochemistry, and BIOL 2520 Physiology, or BIOL 5520 Quantitative Physiology, or HSCI 1020 Human Anatomy & Physiology ll, and Co-req: BIOL 4630L Cardiovascular Physiology Lab.
Cardiovascular Physiology Lab is designed to supplement Cardiovascular Physiology 81.462. The objective of the course is to teach cardiovascular system function using problems sets as well as clinical and pathophysiological examples.
Co-req: BIOL.4620 Cardiovascular Physiology.
A study of the principles and specialized techniques of cloning, purifying, and manipulating recombinant DNA molecules.
Pre-req: BIOL 2350 Genetics or BIOL 3350 Principles of Genetics and BIOL 4190 Biochemistry.
Laboratory experiments and independent projects designed to illustrate current techniques and instrumentation used in genetic engineering. Included are restriction mapping, cloning, plasmid purification, blot hybridization, PCR, and DNA sequencing. Students are introduced to computer software utilized for DNA sequence analysis and manipulation.
Pre-req: BIOL 2350 Genetics, BIOL 4190 Biochemistry, and BIOL 4210L Biochemistry Techniques.
A study of bacterial, animal, and plant viruses, including viral structure, modes of replication, biochemistry of the infected cell, genetic properties, and viral oncogenesis. Emphasis is on virus cell interaction at the molecular level.
A series of lecture and laboratory exercises that will focus on the in vitro culture and analysis of multiple cell type commonly used in biomedical research laboratories. The lecture component will review methodologies used to establish immortalized cell lines, medium component for specific cell types, and techniques for genetically manipulating and analyzing cell lines. The laboratory exercises will emphasize the mastery of sterile techniques used to grow both established cell line and primary cultures, and molecular tools used for introducing recombinant genes and for analyzing cell growth and differentiation.
Pre-req: BIOL.2200 Principles of Cellular Biology, and BIOL.4210L or Biol.5210L Biochemistry Techniques.
This course covers the current understanding of the genetic, molecular, and cellular mechanisms that regulate animal development. Variation in developmental processes, including those involved in evolutionary change as well as disease, are discussed. Specific topics include: fertilization, determination of cell fate and differentiation. establishment of body plans, cell migration, organogenesis, morphogenesis, stem cells, and regeneration.
Pre-req: BIOL.2200 Principles of Cell and Molecular Biology, and Co-req: BIOL.4810L Developmental Biology Lab.
This course provides hands on experience in current methods and model systems used to investigate questions in developmental biology. Students will be exposed to a wide variety of embryonic systems, including intensively studied genetic model systems (e.g.C. elegans, zebrafish, mouse) and others with well-established experimental attributes (e.g. Chick, sea urchin). Analytical and experimental techniques used to explore invertebrate and vertebrate development include embryological manipulation, molecular and cell biology approaches. Conceptual topics include cell specification and differentiation, pattern formation, morphogenesis, and comparative embryology. This lab supplements the Developmental Biology lecture (BIOL.4800).
Co-req: BIOL.4800 Developmental Biology.
A study of the genes and proteins implicated in the cause of human cancer and discussion of the complex behaviors of cancer cells that differ from their normal counterparts in human tissue. Lectures and original research papers will be used.
Pre-Req: 81.220 Principles of Cell & Molecular Biology
A comparative study of vertebrate embryological development focusing on the morphological development (e.g., Differentiation of tissues, organs, and systems) of vertebrates. Evolutionary relationships of the classes of vertebrates will be investigated through their anatomy. This course builds on concepts taught in Developmental Biology, providing more detailed analysis of tissue development in a comparative context.
Structural basis of the molecular biology of cells and the regulation of cellular processes will be discussed. This course will cover the fundamental knowledge about protein, nucleic acid and membrane structure in relation to central systems in biology. Topics to be discussed include structural enzymology, macromolecular assemblies for replication transcription, translation, membrane proteins, signal transduction, cell motility and transport, cell-cell interactions, the immune system, and virus structure.
This course provides grounding in the principles and practice of protein x-ray crystallography. The course will be unique in format and provide both didactic and laboratory instruction. It is comprised of a series of lecture and laboratory exercises, with an emphasis on practical techniques and hands-on experience of modern protein crystallography. The course will cover the fundamental knowledge about x-ray physics, instrumentation and geometrical diffraction, protein crystallization, macromolecular data collection and processing, phase estimation and improvement, model building and refinement, and model assessment. Student will also be given a recently published structural paper for writhing a report on the subject.
This course provides grounding in the principles and practice of protein x-ray crystallography, with some applications in structural bioinformatics and drug discovery. This course is comprised of a series of lecture with an emphasis on practical methodologies of modern protein crystallography and structural bioinformatics. The course will cover the fundamental knowledge about x-ray physics, instrumentation and geometrical diffraction, protein crystallization, macromolecular data collection and processing, phase estimation and improvement, model building and assessment, and some exploration of bioinformatics tools employed in molecular docking and virtual screening.
Pre-req: BIOL.3050 Introduction to Bioinformatics, and PHYS.1040 General Physics II.
This lab course provides grounding in the principles and practice of protein x-ray crystallography, with some applications in structural bioinformatics and drug discovery. It covers topics correlated with the co-requisite lecture course BIOL.4892.
Co-req: BIOL.4892 Crystallography and Structural Bioinformatics.
A study of cellular and systems neurobiology with a focus on how these relate to human health and disease. Particular attention will be given to illustrating functional neuroanatomy and neurophysiology of the human CNS using investigations into the pathogenic mechanisms of a variety of human neurodegenerative diseases including epilepsy, Alzheimer's Disease, Huntington's Disease, ALS among others.
Note: Graduate level enrollees will be responsible for additional reading and writing.
Pre-req or Co-req: 81.419 Biochemistry.
Individual, directed one semester research project taken in the fall and/or spring. Presentation of an acceptable project plan at the time of registration is required. A project report is required.
A study of the nature of the immune response with sections on antibody structure, function and production; antigen-antibody reactions; immunogenetics; and immune regulation, protection and injury.
Pre-Req: BIOL 1110 Principles of Biology I, BIOL 1170L Principles of Biology I, BIOL 1120 Principles of Biology II, and BIOL 1180L Principles of Biology II
This course will focus on recent advances in the field of immunology including the study of immune development and activation, response to infection, vaccines, immunoregulation, cancer immunotherapy, and immune dysfunction. Expanding upon the foundational immunologic concepts covered in BIOL.4930/BIOL.5930, students will gain knowledge of the innate and adaptive immune system at the structural, molecular, cellular, and functional levels. The objectives of Advanced Topics in Immunology are to gain a comprehensive and practical understanding of current immunological principles in research and clinical/applied sciences, learn to critically read and evaluate scientific literature, learn to interpret data, and design experiments that rigorously test hypotheses.
Pre-req: BIOL.4930 or BIOL.5930 Immunology.
This transdisciplinary course will examine the interface between pathogens and their hosts at multiple levels. We will begin with molecular and cellular interactions between host and pathogen species and will expand to include ecological patterns, behavioral biology, and host-pathogen co-evolution. Following an introduction to infectious disease, microbiology, and immunology, we will critically read and evaluate scientific literature. The objectives of Host-Pathogen Interactions are to gain a comprehensive and practical understanding of host-pathogen dynamics, pattern of disease ecology, and host-pathogen co-evolution. Students will learn to critically read and evaluate scientific literature, interpret data, and design experiments.
Pre-req: BIOL.2220 Principals of Cell and Molecular Biology.
A series of basic laboratory exercises dealing with the preparation, isolation and characterization of antigens, antibodies and effector cells.
Co-Req: 81.493 Immunology.
On-campus and/or off-campus experiences are developed by the student in consultation with a member of the student's major department. Specific requirements will vary depending upon department policies and the nature of the program undertaken by the student. The intent of the practicum experience is to provide an occasion for investigation of a scientific area and for applying techniques of problem solving and/or skills which are appropriate to the student's major discipline. The practicum experience may not be substituted for a required course in the major.
Presents environmental and organismal structural interrelationships and relates these to the chemical evolutionary basis of life.
Not suitable for credit towards any degree in the Division of Sciences.
Anti-Req: BIOL.1110 and BIOL.1220 and BIOL.2100 and LIFE.1010.
Presents environmental and organismal structural interrelationships and relates these to the chemical evolutionary basis of life. Suitable as a Natural Science Elective for a degree in the Division of Sciences.
Anti-Req: LIFE.1000 and BIOL.1110 and BIOL.1220 and BIOL.2100.
Emphasis is on systems structure and function. The cellular organization of plants and animals leads into physiological processes of higher organisms with great emphasis on humans. Among topics considered are nutrition and digestion, cellular metabolism, circulation, respiration, excretion, nervous and skeletal-muscular systems. Also considered are the chemical interactions of these systems with immunity, hormonal and reproductive processes.
Suitable as a Natural Science Elective for a degree in the Division of Sciences.
Concerned with experimentation and interpretation of some of the concepts of Life Science I.
Suitable as a Natural Science Elective for a degree in the Division of Sciences.
Pre/Co-Req: LIFE.1010 Life Science I.
Involved with experimentation and interpretation of some of the concepts of Life Science II.
Suitable as a Natural Science Elective for a degree in the Division of Sciences.
Introduction to Biology Laboratory is a co-requisite course for the Introduction to Biology online lecture course - 83.100. The two courses together fulfill a GenEd Science requirement. The lab course can be taken concurrently with the lecture course or subsequent to it. Weekly labs correspond directly with the chapter assignments provided by the 83.100 instructors.
Pre-Req or Co-Req: LIFE.1000 Intro to Biology; not for Biology majors.
Human Biology is designed to be an accelerated online summer course for non-science majors. This course will cover the major organ systems of the human body (cardiovascular, digestive, nervous, excretory, etc.), how they function and the disorders that arise when these systems don't function as they were intended.
This course is a laboratory course for non-science majors and is designed to accompany the Human Biology (LIFE.1060) lecture course. It will help reinforce the concepts investigated in the lecture course which involves the study of structure (anatomy) and function (physiology) of the major organ systems in the human body. Students will engage in the process of science, make observations,develop questions, collect and analyze data by performing virtual lab experiments, and communicate the results of scientific work in assigned weekly lab reports. Not suitable for credit towards any degree in the College of Sciences.
Pre-req or Co-req: LIFE.1060 Human Biology.
This course is an integrated lecture and laboratory course for non-science majors and is designed to fulfill the core laboratory science requirement. The course will present fundamental principles of biochemistry in the context of cooking and foods to explain everyday phenomena. Class periods will include lecture and discussion and there will be laboratory assignments to be completed by the student.
Examines historical aspects of microbial interactions with human society, including the use of microbes in food production, agriculture, biotechnology, industry and environmental preservation; explores bioterrorism, the problem of antibiotic resistance and surveys some historical and contemporary microbial diseases.
Serves as an interdisciplinary survey course for students not majoring in biology, which deals with human nutrition as it relates to various chronic disease states. Methods of detection and treatment of the disorders are considered as well as general concepts of health promotion/disease prevention based on the Dietary Guidelines for Americans. Specific topics covered include the role of nutrition in: heart disease, diabetes, cancer, obesity, alcoholism, and eating disorders. Not suitable for credits toward any degree in the Division of Sciences.
This course is designed to introduce undergraduate students to the fascinating world of plants and their significance in our everyday world. The use of plants in medicine, agriculture, and industry and their importance to humans and our environment will be emphasized. This course is also designed to fulfill the core science elective requirement for the non-science major. Not suitable for credit towards any degree in the Division of Sciences.
Plants and Human Society Laboratory is a co-requisite course for the Plants and Human Society online lecture course LIFE.1250. The two courses together fulfill the core science with laboratory requirement. The lav course can be taken concurrently with the lecture course or subsequent to it. Weekly labs correspond with the chapter assignments in the lecture course. Not suitable for credit towards any degree in the Division of Sciences.
Pre-Req or Co-Req: LIFE.1250 Plants & Human Society.
Life Science 1000 level elective.
Designed to reveal and discuss the increasing problems of overpopulation in regard to environmental deterioration, living space, limits of natural resources and the adverse effects of human alteration on destruction of the natural ecosystem. The implications of current literature and news items will be emphasized.
Not suitable for credit towards any degree in the Division of Sciences.
The Job Search Seminar is designed to provide students with the necessary structure, resources, and support to facilitate their career development and the pursuit of career goals. Through a variety of interactive teaching methodologies and assignments, students will participate in a sequence of learning activities including self-assessment, career exploration, and the job search process. The latter will include resume and cover letter writing, the online search, professional networking, and strategic interviewing. The goal of the course is to assist each student in developing a sound plan of action in pursuing their career objectives.