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The purpose of this introductory course in the pharmaceutical sciences is to provide an overview of the drug development process, involving drug discovery, drug action, and drug delivery. The student will become acquainted with cutting-edge research in discovery, action, and delivery. This course provides a foundation in pharmaceutical sciences along with theoretical, practical, regulatory, and professional issues in the pharmaceutical sciences.
The purpose of this introductory course in the pharmaceutical sciences is to provide an overview of the drug development process, involving drug discovery, drug action, and drug delivery. Laboratory experiments will be performed to exemplify and expand upon the principles covered in Principles of Pharmaceutical Sciences lecture.
This course focuses of the study of the biochemical and physiological effects of drugs and the mechanisms of their actions. The quantitative aspects of drug absorption, distribution, metabolism, and excretion will be explored. The philosophy of pharmacokinetic modeling and its application in practice will be introduced.
Pre-req: PHRM.6100 Principles of Pharmaceutical Sciences.
This course explores research methodologies and statistics that are commonly used in pharmaceutical research. Scientific integrity in research will be discussed, as well as ethical issues in conducting pharmaceutical research in the laboratory.
Students in this course learn about modern analytical methods used to analyze the purity, strength, and quality of drugs and pharmaceutics.
Pre-req: PHRM.6100 Principles of Pharmaceutical Sciences, and Co-reg: PHRM.6420 Pharmaceutical Analysis Lab.
The biological, biophysical and chemical factors that influence drug delivery systems will be analyzed. Principles of cellular drug transport, in vivo drug transport, and modern drug delivery, including drug targeting will be explored. The course will also address membrane trafficking and intracellular transport and the utilization of these mechanisms in drug delivery and targeting.
Students in this course analyze the purity, strength, and quality of drugs and pharmaceutics by applying modern analytical methods. Raw materials and completed dosage forms will also be analyzed in the laboratory.
Co-req: PHRM.6400 Pharmaceutical Analysis.
Drug discovery is the translational application of biology, chemistry, medicine, business and law in the identification of new medicines. This course is designed to provide each student with a full understanding of the challenges and opportunities that face scientists engaged in this enterprise in the biotech and pharmaceutical industries. Active learning objectives (case studies; project team work0 are included to supplement the more didactic course materials, and to provide a simulation of the approaches used in industry to accomplish the key goal-the nomination of a clinical drug candidate worthy of extensive investment and testing in humans.
This course focuses of the study of the biochemical and physiological effects of drugs and the mechanisms of their actions. The quantitative aspects of drug absorption, distribution, metabolism, and excretion will be explored. The philosophy of pharmacokinetic modeling and its application in practice will be introduced. An overview of the structure, function and regulation of major drug metabolic enzymes and transporters will also be emphasized.
This course provides an overview of the structure, function and regulation of major drug metabolic enzymes and transporters.
This course reviews the general principles of drug action and the pharmacological activities of various classes of drugs. The major focus is on the molecular mechanisms of drug action, with a detailed discussion of one or more prototypes of each drug class. Selected examples of drug discovery and development are also discussed. At the completion of the course, students will have knowledge of the molecular basis of pharmacological activity, the mode of action of major classes of therapeutic agents and familiarity with rational approaches to drug design.
Pharmacogenomics utilizes knowledge related to the variability in the human genome to understand and predict the differences in drug response and toxicity of pharmaceutical agents. This includes not only the determination of pharmacologically relevant genes that alter individual pharmacokinetic and pharmacodynamic response but also those polymorphism's and other mutations that predispose a person to development of various diseases. Personalizing therapies based on genotypic information should increase efficacy and decrease toxicity of agents. Current applications covered include anti-cancer and anti-viral therapies and anticoagulation.
Pre-req: 36.707 Drug Metabolism
Select advanced topics and the evaluation of scientific literature in pharmaceutical sciences will be discussed in this seminar.
Experimental research methodologies and the ethical issues in clinical pharmaceutical research will be analyzed. Principles of translational research will be discussed. Students will develop a pharmaceutical clinical trial protocol.
In this course the student applies epidemiological knowledge, reasoning, and research methods to the examination of the use and effectiveness of pharmacotherapy in human populations.
This course reviews the major methods, models, and equations used in pharmacokinetics with their physicochemical and physiological assumptions and limitations. Current graphic and computer methods of applying pharmacokinetics experimental and clinical data will be explored. Clinical research literature and approaches to the design of studies will be explored.
Pre-req: PHRM 6100 Principles of Pharmaceutical Sciences, and PHRM 6200 Pharmacokinetics.
A multidisciplinary course covering nanotechnology based drug delivery, materials and processes for novel drug delivery systems, synthesis of biocompatible nanoparticles for healthcare, product design, products today and regulatory issues.
Enrolled students will be completing supervised research as they progress toward the completion of their degree.
Enrolled students anticipate completion of all dissertation requirements during the semester in which they are enrolled for this course.