The UMass Lowell Department of Physical Therapy & Kinesiology enhances the well-being and quality of life of humans through the generation of scientific knowledge and development of evidence-based practice. Our faculty hold national and international recognition for their areas of expertise, which is evidenced by the publication of numerous research articles in high impact scientific journals and the authorship of some of the most widely utilized textbooks in the fields of sports medicine, physical therapy, athletic training, kinesiology, biomechanics, exercise science, and rehabilitation science. In addition, many undergraduate and graduate students have been authors or co-authors on this work through the mentorship of department faculty.

Click on the plus signs below to expand the list of publications by year.

  • Manuscripts

    Chen YN, Wu YN, Yang BS. The neuromuscular control for lower limb exoskeleton- a 50-year perspective. J Biomech. 2023;Sep:158:111738.

    Chen MJ, Xu Y, Sirois A, Li Y, Dempski R, Smith GM, Oda Y, Telliel YD, Lewis E, Wolkowicz K. WheelUp! Developing an interactive electric-power wheelchair virtual training environment. IEEE Conference on Games (CoG). 2023:1-6.

    Clark PJ, Buhr TJ, Reed CH, Wee OM, Lee JH, Yuan LL, Fleshner M, Valentine RJ. The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress. Front Behav Neurosci. 2023;14:1169151.

    Dhorajia VV#, Kim J, Kim Y. Early adaptive responses in the skeletal muscle of young mice with hereditary hemochromatosis. Mol Biol Rep. 2023;50(4):3179-3187.

    Gannotti ME, O'Neil ME, Fragala-Pinkham M, Gorton GE, Whitney DG. Policy brief: adaptive cycling equipment for individuals with neurodevelopmental disabilities as durable medical equipment. Front Rehabil Sci. 2023;4:1160948.

    Gao Y#, Epstein S#, Inalpolat M, Wu YN, Gu Y. Modeling of interface loads for EOD suit wearers. arXiv e-prints. 2023:arXiv-2302.

    Gauthier L, Rider JV, Donkers S. Applying behavior change techniques to support client outcomes in outpatient neurorehabilitation: a clinician guide. Arch Phys Med Rehabil. 2023;104(4):711-715.

    Kao PC, Lomasney C^, Gu Y, Clark JP, Yanco HA. Effects of induced motor fatigue on walking mechanics and energetics. J Biomech. 2023;156:111688.

    Katti P, Kim Y, Sundaresan NR, Gouspillou G, Hinton A Jr. Cite. Editorial: Muscle plasticity: regulation of adaptive changes in muscles and mitochondrial dynamics. Front Physiol. 2023;14:1192759.

    Krishna S, Echevarria KG, Reed CH, Eo H, Wintzinger M, Quattrocelli M, Valentine RJ, Selsby JT. A fat- and sucrose-enriched diet causes metabolic alterations in mdx mice. Am J Physiol Reg Integr Comp Physiol. 2023;325(6):R692-R711.

    Krishna S, Spaulding HR, Koltes JE, Quindry JC, Valentine RJ, Selsby JT. Indicators of increased ER stress and UPR in aged D2-mdx and human dystrophic skeletal muscle. Front Physiol. 2023;14:1152576.

    Kwon OS, Tamura Y, Kim Y. Editorial: New insights into the role of mitochondria in muscle pathophysiology. Front Physiol. 2023;14:1151120.

    Peznola S, Gauthier LV, Claypool MC, Roop B, Lammert AC. Compliance with in-home self-managed rehabilitation post-stroke is largely independent of scheduling approach. Arch Phys Med Rehabil. 2023;104(4):554-561.

    Renner MN, Gnacinski SL, Porter FJ, Cornell DJ. The influence of age and dynamic balance on functional movement among active-duty police officers. J Sport Rehabil. 2023;32(3):242-247.

    Shen J, Gauthier LV, Li W. A population-based study on injury risk and disparities among children with ADHD. J Atten Disord. 2023;27(8):859-866.

    Shen J, Shi J, Gauthier LV, Li W. The economic burden of injuries in children with ADHD in the U.S. from 2011 to 2020. J Atten Disord. 2023;27(14):1561-1570.

    ^denotes undergraduate student author
    #denotes graduate student author

  • Manuscripts

    Alley JR, Valentine RJ, Kohut ML. Mitochondrial mass of naïve T cells is associated with aerobic fitness and energy expenditure of active and inactive adults. Med Sci Sports Exer. 2022;54(8):1288-1299.

    Bhat A, Fiss A, O'Neil ME, Sansom JK, Heathcock JC, Dusing SC, Christy JB, APTA APPT Research Agenda Task Force. Steps to revising the APTA Pediatrics research agenda. Pediatr Phys Ther. 2022;34(3):418-420.

    Borstad A, Nichols-Larsen D, Uswatte G, Strahl N, Simeo M, Proffitt R, Gauthier L. Tactile sensation improves following motor rehabilitation for chronic stroke: the VIGoROUS randomized controlled trial. Neurorehabil Neural Repair. 2022;36(8):525-534.

    Eo H, Valentine RJ. Saturated fatty acid-induced ER stress and insulin resistance are prevented by imoxin in C2C12 myotubes. Front Physiol. 2022;13:842819.

    Gauthier LV, Nichols-Larsen DS, Uswatte G, Strahl N, Simeo M, Proffitt R, et al. Video Game Rehabilitation for Outpatient Stroke (VIGoROUS): a multi-site randomized controlled trial of in-home, self-managed, upper-extremity therapy. eClinicalMedicine. 2022;43:101239.

    Himariotis AT#, Coffey KF, Noel SE, Cornell DJ. Validity of a smartphone application in calculating measures of heart rate variability. Sensors. 2022;22(4):9883.

    Kao PC, Norton A, Wu YN, Ramsay JW, Gregorczyk KN, Yanco HA. Characterizing human performance during soldier-relevant tasks with a knee-actuated exoskeleton. J DoD Res Eng. 2022;5(4):12-24.

    Kao PC, Pierro MA#. Motor adaptation to cognitive challenges and walking perturbations in healthy young adults. Gait Posture. 2022;92:167-175.

    Katti P, Hall AS, Parry HA, Ajayi PT, Kim Y, Willingham TB, Bleck CKE, Wen H, Glancy B. Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles. Nature Commun. 2022;13(1):6058.

    Kim Y, Ajayi PT, Bleck CKE, Glancy B. Three-dimensional remodeling of the cellular energy distribution system during postnatal heart development. Philos Trans R Soc Lond B Biol Sci. 2022;377(1864):20210322.

    Lefferts WK, Davis MM, Valentine RJ. Exercise is aging: a new perspective on the mechanisms behind exercise as preventive medicine against age-related chronic disease. Front Physiol. 2022;13:866792.

    Rafiei MH, Gauthier LV, Adeli H, Takabi D. Self-supervised learning for electroencephalography. IEEE Trans Neural Netw Learn Syst. 2022:PP.

    Reed CH, Buhr TJ, Tystahl AC, Bauer EE, Clark PJ, Valentine RJ. Effects of voluntary wheel running and alcohol consumption on skeletal muscle signaling in female mice. Alcohol. 2022;104:45-52.

    Seo G, Lee SW, Beer RF, Alamri A, Wu YN, Raghavan P, Rymer WZ, Roh J. Alterations in motor modules and their contribution to limitations in force control in the upper extremity after stroke. Front Hum Neurosci. 2022;16:937391.

    Summers CM, Valentine RJ. Two hours of heat stress induces MAP-Kinase signaling and autophagasome accumulation in C2C12 myotubes. Cell Biochem Biophys. 2022;80(2):367-73.

    Wu YN, Norton A, Zielinski MR, Kao PC, Stanwicks A#, Pang P#, Cring CH, Yanco H. Characterizing the effects of explosive ordnance disposal operations on the human body while wearing heavy personal protective equipment. Hum Factors. 2022;64(7):1137-1153.

    Book Chapters / Textbooks

    Moriarty-Baron J, O’Sullivan SB. Interventions to improve standing and standing balance skills. In: Bezkor EW, O’Sullivan SB, Schmitz TJ. Improving Functional Outcomes in Physical Rehabilitation, 3rd ed. Philadelphia, PA: FA Davis Company; 2022:235-267. ISBN: 9781719640909

    Moriarty-Baron J. Interventions for vestibular rehabilitation. In: Bezkor EW, O’Sullivan SB, Schmitz TJ. Improving Functional Outcomes in Physical Rehabilitation, 3rd ed. Philadelphia, PA: FA Davis Company; 2022:349-375. ISBN: 9781719640909

    Moriarty-Baron J. Case Study 9: Patient with vestibular dysfunction. In: Bezkor EW, O’Sullivan SB, Schmitz TJ. Improving Functional Outcomes in Physical Rehabilitation, 3rd ed. Philadelphia, PA: FA Davis Company; 2022:441-443. ISBN: 9781719640909

    ^denotes undergraduate student author
    denotes graduate student author

  • Manuscripts

    Bailey JE, Gurgol C, Pan E, Njie S, Emmett S, Gatwood J, Gauthier L, Rosas LG, Kearney SM, Robler SK, Lawrence RH. Early patient-centered outcomes research experience with the use of telehealth to address disparities: scoping review. J Med Internet Res. 2021;23(12):e28503.

    Bries AE, Webb JL, Vogel B, Carrillo C, Day TA, Kimber MJ, Valentine RJ, Rowling MJ, Clark S, Schalinske KL, McNeill EM. RNA sequencing reveals key metabolic pathways are modified by short-term whole egg consumption. Front Nutr. 2021;8:652192.

    Buhr TJ, Reed CH, Shoeman A, Bauer EE, Valentine RJ, Clark PJ. The influence of moderate physical activity on mouse brain monoaminergic responses to binge-patterned alcohol ingestion. Front Behav Neurosci. 2021;15:639790.

    Cheng R#, Dhorajia VV#, Kim J, Kim Y. Mitochondrial iron metabolism and neurodegenerative diseases. Neurotoxicology. 2021;88:88-101.

    Cornell DJ, Ebersole KT, Azen R, Zalewski KR, Earl-Boehm JE, Alt CA. Measures of functional movement quality among firefighters. Athl Train Sports Health Care. 2021;13(5):262-270.

    Cornell DJ, Gnacinski, SL, Ebersole KT. Functional movement quality of firefighter recruits: longitudinal changes from the academy to active-duty status. Int J Environ Res Public Health. 2021;18(7):3656.

    Cornell DJ, Noel SE, Zhang X, Ebersole KT. Influence of body composition on post-exercise parasympathetic reactivation of firefighter recruits. Int J Environ Res Public Health. 2021;18(1):339.

    Dean N#, Gu Y, Kao PC, Wu YN, Zielinski M, Inalpolat M. Pressure monitoring based identification of the EOD suit-human interface load distribution. Int J Intell Robot Appl. 2021;5:410-423.

    DiCarlo JA, Gheihman G, Lin DJ, 2019 Northeast Cerebrovascular Consortium Conference Stroke Recovery Workshop Participants (Gauthier LV). Reimagining stroke rehabilitation and recovery across the care continuum: results from a design-thinking workshop to identify challenges and propose solutions. Arch Phys Med Rehabil. 2021;102(8):1645-1657.

    Eo H, Valentine RJ. Imoxin inhibits tunicamycin-induced ER stress and restores insulin signaling in C2C12 myotubes. Am J Physiol Cell Physiol. 2021;321(2):C221-229.

    Gauthier LV, Proffitt R, Borstad A, Kelly K. Constraint-induced movement therapy via telehealth builds client autonomy with therapist guidance. Brain Inj Prof. 2021;18(2):20-21.

    Kao PC, Pierro MA#, Wu T#, Gonzalez DM^, Seeley R#. Association between functional physical capacity and cognitive performance under destabilizing walking conditions in older adults. Exp Gerontol. 2021;155:111582.

    Kao PC, Pierro MA#. Dual-task treadmill walking at self-paced versus fixed speeds. Gait Posture. 2021;89:92-101.

    Luna A, Casertano L, Timmerberg J, O’Neil ME, Machowsky J, Leu CS, Lin J, Fang Z, Douglas W, Agrawal S. Artificial intelligence application versus physical therapist for squat evaluation: a randomized controlled trial. Sci Rep. 2021;11(1):18109.

    Marciniak RA, Ebersole KT, Cornell DJ. Relationships between balance and physical fitness variables in firefighter recruits. Work. 2021;68(3):667-677.

    Nein C, Chen KH, Wu YN, Chuang SL, Yang BS. Using range of motion to examine the effects of deep brain stimulation on gait function of Parkinson’s disease patients with freezing of gait: a proof-of-concept study. J Biomech Sci Eng. 2021:16(2):21-00093.

    Noel SE, Cornell DJ, Zhang X, Mirochnick JC#, Mattei J, Falcón LM, Tucker KL. Patterns of change in cardiovascular risk assessments and ankle brachial index among Puerto Rican adults. PLoS One. 2021;16(1):e0245236.

    Sherriff TJ#, Ebersole KT, Cornell DJ. Relationship between gastrocnemius muscle length and overhead squat movement compensations among active-duty firefighters. Int J Athl Ther Train. 2021;26(4):230-235.

    Shirazi BR, Valentine RJ, Lang JA. Reproducibility of novel indices of reactive hyperemia using laser speckle contrast imaging. PLoS One. 2021;16(1):e0244795.

    Wu YN, Stark C#, Gravel J, White M, Avery J, Enis T, Cantu RC. Effects of interval-training exercise on people who have had persistent post-concussive symptoms for less than one year: a pilot study. J Neurotrauma. 2021;38(5):573-581.

    ^denotes undergraduate student author
    #denotes graduate student author

  • Manuscripts

    Ahmadi M, O’Neil ME, Baque E, Boyd R, Trost SG. Machine learning to quantify physical activity in children with cerebral palsy: comparison of group, group-personalized and fully-personalized activity classification models. Sensors. 2020;20(14):3976.

    Cornell DJ, Ebersole KT. Influence of an acute bout of self-myofascial release on knee extension force output and electro-mechanical activation of the quadriceps. Int J Sports Phys Ther. 2020;15(5):732-743.

    Cornell DJ, Noel SE, Zhang X, Ebersole KT. Influence of a training academy on the parasympathetic nervous system reactivation of firefighter recruits – an observational cohort study. Int J Environ Res Public Health. 2020;18(1):109.

    Ebersole KT, Cornell DJ, Flees RJ, Shemelya CM, Noel SE. Contributions of the autonomic nervous system to recovery in firefighters. J Athl Train. 2020;55(9):1001-1008.

    Eo H, Reed CH, Valentine RJ. Imoxin prevents dexamethasone-induced promotion of muscle-specific E3 ubiquitin ligases and stimulates anabolic signaling in C2C12 myotubes. Biomed Pharmacother. 2020;128:110238.

    Fragala-Pinkham M, O’Neil ME. Clinical Bottom Line: Commentary on ‘I Want to Play: Children with Cerebral Palsy Talk About their Expectations on Barriers and Facilitators to Participation in Leisure Activities’. Pedatr Phys Ther. 2020;32(3):190-200.

    Glancy B, Kim Y, Katti P, Willingham TB. The functional impact of mitochondrial structure across subcellular scales. Front Physiol. 2020; 11:541040.

    Habib-Hasan, Sheikh MS, Hoodbhoy Z, Azam I, O’Neil M. Early intervention physical therapy using “Parent Empowerment Program” for children with Down syndrome in Pakistan: a feasibility study. J Pediatr Rehabil Med. 2020:13(3):233-240.

    Karamians R, Proffitt R, Kline D, Gauthier LV. Effectiveness of virtual reality-and gaming-based interventions for upper extremity rehabilitation poststroke: a meta-analysis. Arch Phys Med Rehabil. 2020;101(5):885-896.

    Kim Y, Lindberg E, Bleck CKE, Glancy B. Endothelial cell nanotube insertions into cardiac and skeletal myocytes during coordinated tissue development. Cardiovasc Res. 2020;116(2):260-261.

    O’Neil ME. Examining the relationship between weight gain trajectories and pain free interference during transitions from adolescents to adulthood: informing prevention and intervention strategies. Pain Med. 2020;21(3):435-436.

    Summers CM, Valentine RJ. Effects of heat on autophagy signaling in C2C12 myotubes. Front Physiol. 2020;10:1521.

    Tsai LC, Wu YN, Liu SQ, Zhang LQ. Changes in muscle stress and sarcomere adaptation in mice following ischemic stroke. Front Physiol. 2020;11:581846.

    Valentine RJ, Rowling MJ, Clark S, McNeill E, Schalinske KL. Differential gene expression of Zucker Diabetic Fatty rats fed whole egg. PLoS One. 2020;15(11):e0240885.

    Willingham TB, Kim Y, Lindberg E, Bleck CKE, Glancy B. The unified myofibrillar matrix for force generation in muscle. Nat Commun. 2020;11(1):3722.

    Xu D, Wu YN, Gaebler-Spira D, Gao F, Clegg NJ, Delgado MR, Zhang L-Q. Neural and non-neural contributions to ankle spasticity in children with cerebral palsy. Dev Med Child Neurol. 2020; 62(9):1040-1046.

    Books Chapters / Textbooks

    Gilbertson T, Hsu LY, McCoy SW, O’Neil ME. Gaming technologies for children and youth with Cerebral Palsy. In: Miller F, Bachrach S, O’Neil ME, Lennon M. Cerebral Palsy, 2nd ed. New York City, NY: Springer Publishers; 2020:2917-2945. ISBN: 9783319745572

    O’Neil ME, Lennon N. Therapy management of the child with Cerebral Palsy: an overview. In: Miller F, Bachrach S, O’Neil ME, Lennon M. Cerebral Palsy, 2nd ed. New York City, NY: Springer Publishers; 2020:2395-2404. ISBN: 9783319745572

    ^denotes undergraduate student author
    denotes graduate student author

  • Manuscripts

    Kim Y, Yang DS, Katti P, Glancy B. Protein composition of the muscle mitochondrial reticulum during postnatal development. J Physiol. 2019;597(10):2707-2727.

    Kim Y, Triolo M, Erlich AT, Hood DA. Regulation of autophagic and mitophagic flux during chronic contractile activity-induced muscle adaptations. Pflugers Arch. 2019;471(3):431-440.

    Landis C, O'Neil ME, Finnegan A, Shewokis PA. Calculating heart rate variability from ECG data from youth with Cerebral Palsy during active video game sessions. J Vis Exp. 2019;148:e59230.

    Loverro KL, Khuu A, Kao PC, Lewis CL. Kinematic variability and local dynamic stability of gait in individuals with hip pain and a history of developmental dysplasia. Gait Posture. 2019;68:545-554.

    Mammadova N, Kokemuller RD, Summers CM, He Q, Ding S, Baron T, Yu C, Valentine RJ, Sakaguchi DS, Kanthasamy AG, Greenlee JJ, Greenlee HW. Accelerated accumulation of retinal α-synuclein (pSer129) and tau, neuroinflammation and autophagic dysregulation in a seeded mouse model of Parkinson’s disease. Neurobiol Dis. 2019;121:1-16.

    O’Neil ME, Fragala-Pinkham M. Clinical Bottom Line: Commentary on ‘Preliminary aquatic core sets for children and youth with neurological disorders: consensus process’. Pediatr Phys Ther. 2019;31(3):279.

    Rafiei MH, Kelly KM, Borstad AL, Adeli H, Gauthier LV. Predicting improved daily use of the more affected arm poststroke following constraint-induced movement therapy. Phys Ther. 2019;99(12):1667-1678.

    Saande CJ, Steffes MA, Webb JL, Valentine RJ, Rowling MJ, Schalinske KL. Whole egg consumption impairs insulin sensitivity in rat model of obesity and type 2 diabetes. Curr Dev Nutr. 2019;3(4): nzz015.

    Van de Winckel A, Gauthier L. A revised motor activity log following Rasch Validation (Rasch-Based MAL-18) and consensus methods in chronic stroke and multiple sclerosis. Neurorehabil Neural Repair. 2019;33(10):787-791.

    Book Chapters / Textbooks

    O’Sullivan SB, Schmitz TJ, Fulk G, eds. Physical Rehabilitation. 7th ed. Philadelphia, PA: FA Davis Company; 2019. ISBN: 9780803661622