Maurizio Cattaneo

Maurizio V. Cattaneo, Ph.D.

Research Professor

Francis College of Engineering
Chemical Engineering
Southwick Hall, Room 201 & 202


Quality by Design, Process Analytical Technologies for Bioprocess Development, Viral Vector Manufacturing

Research Interests

Developing viral and non-viral delivery systems (AAV, LV and RV, LNPs), Developing an AI/deep learning hyperspectral imaging for real time monitoring of PTM, Patented a Viral Harvest Unit (VHU) for the perfusion of viral vectors in bioreactors


  • Ph.D.: Chemical Engineering, McGill University, Montreal, Canada, 1990
  • M.Eng.: Chemical Engineering, McGill University, Montreal, Canada, 1986
  • Bachelor of Science, University of Toronto, Toronto, Canada, 1982


With over 30 years of experience in the biotech sector, Maurizio Cattaneo, Ph.D., has led cutting edge research and development in several NIH funded health science projects and founded startup companies in the area of drug formulation (IVREA Pharmaceuticals), Contract Development and Manufacturing (BioVolutions) and Technology Development (Artemis Biosystems), which has enabled him to refine his expertise in the area of Quality by Design and Process Analytical Technology Development for Bioprocesses.

Selected Awards and Honors

  • 1978 Ontario Scholar
  • 1980 Research Grant, National Sciences and Engineering Research Council
  • 1997 Government Priority Funds for Science and Technology, National Research Council of Canada

Selected Publications

  • Mark-Henry Kamga, Maurizio Cattaneo & Seongkyu Yoon (2018) Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation for optimum resin utilization and productivity, Preparative Biochemistry & Biotechnology, 48:5, 383-390
  • Hein MD, Chawla A, Cattaneo M, Kupke SY, Genzel Y & Reichl U (2021) Cell culture-based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system. Applied Microbiology and Biotechnology, 105:7251-7264.
  • Marc D. Hein MD, Kazenmaier D, van Heuvel Y, Dogra T, Cattaneo M, Sascha Y, Kupke SY, Stitz4 J, Genzel Y, Reichl U (2023) Production of retroviral vectors in continuous high cell density culture. Applied Microbiology and Biotechnology 107:5947–5961
  • Hevaganinge A, Weber CM, Filatova A, Musser A, Neri A, Conway J, Yuan Y, Cattaneo M, Clyne AM, and Tao Y (2023) Fast-Training Deep Learning Algorithm for Multiplex Quantification of Mammalian Bioproduction Metabolites via Contactless Short-Wave Infrared Hyperspectral Sensing. ACS Omega 8, 14774-14783

Selected Presentations

  • Pisano R, Capozzi LC, Trout BL and Cattaneo MV, Continuous Freeze-Drying of Pharmaceuticals and Biopharmaceuticals, 7th Annual Biomanufacturing Summit, May 22, 2017, Boston, MA.
  • Cattaneo , MV, Rodenbrock A, Spanjaard RA, Ansorge S, Continuous perfusion for an order of magnitude increase in lentiviral vector production, 27th Meeting of the European Society for Cell and Gene Therapy, Barcelona, Spain, October October 22-25, 2019.
  • Cattaneo, MV, Rodenbrock A, Lanthier S, Burney E, Manceur A, Continuous perfusion with a stable producer HEK293 cell line for scaling up lentiviral vector production, 23rd Meeting of the American Society for Gene and Cell Therapy, May 12-15, 2020.

Selected Intellectual Property

  • Cattaneo MV and Spanjaard RA. Perfusion Filtration Systems, US Patent 10,358,626 B2. July 23, 2019
  • Cattaneo MV and Spanjaard RA. Perfusion Filtreation Systems, US Patent 10,998,725 B2 April 27, 2021

Selected Contracts, Fellowships, Grants and Sponsored Research

  • 2000 1R43CA086653-01, Principal Investigator, “Controlled Percutaneous Delivery of Retinoids. ”, SBIR Phase I, National Cancer Institute/NIH Award, Principal Investigator, In collaboration with Prof. MF Demierre, Director, Skin Oncology, Boston University Medical Center.
  • 2001 1R43AG019527-01, SBIR Phase I, National Institute of Aging/NIH Award, Principal Investigator, In collaboration with Prof. Tania Phillips, Department of Dermatology, Boston University Medical Center, Title Topical Estrogen/CB Patch for Wound Healing in Elderly”.
  • 2002 1R43AT001580-01, Principal Investigator, “Intraarticular injection of polyglucosamine for knee OA. In collaboration with Tim McAlindon, Associate Professor Rheumatology, Boston University School of Medicine.
  • 2003 2R44CA0856653-02A1, Principal Investigator, “Topical Retinoids for Chemoprevention of Melanoma”. In collaboration with BU Faculty, Department of Dermatology.
  • 2004 5R44CA086653-03, Principal Investigator, “Topical Retinoids for Chemoprevention of Melanoma”. In collaboration with BU Faculty, Department of Dermatology.
  • 2004 1R43HL78029-1, LEE, IKE W as PI, “Bone Marrow 3D Cell Constructs for Cardiac Repair”

Research Currently in Progress

  • Development of CELiD DNA for Non-Viral Gene Therapy for Type I Diabetes
  • Encapsulation of biologics/DNA/RNA for non-viral gene therapy
  • Delivery of DNA/RNA for gene therapy using AAV and LV Viral Vectors