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Seongkyu Yoon

Seongkyu Yoon
Seongkyu YoonAssistant Professor, Director
  • CollegeFrancis College of Engineering
  • DepartmentChemical Engineering
  • Phone(978) 934-4741

Research Interests

Process system engineering in biologics and life sciences

Process Analytical Technology (PAT) and Quality By Design (QbD) Application of experimental design and multivariate data analysis in biopharmaceuticals Supply chain management in biologics; and Chemometrics in life sciences


  • Ph D: Chemical Engineering, (2001), McMaster University - Hamilton, Canada
    Dissertation/Thesis Title: Using External Information for Statistical Process Control
  • Ph D: Mechanical Engineering, (1998), Tufts University - Medford, MA
  • MS: Chemical and Biomolecular Engineering, (1990), Korea Advanced Institute of Science and Technology - Daejon, Korea
    Dissertation/Thesis Title: "Constrained multivariable Model Algorithmic Control and its Non-Minimum Phase Characteristics."
  • BS: Chemical Engineering, (1988), Yonsei University - Seoul, Korea
  • MS: Computer Science, (1972), Worcester Polytechnic Institute - Worcester, MA
  • BS: Electrical Engineering, (1966), Massachusetts Institute of Technology -
  • BS: Industrial Management, (1966), Massachusetts Institute of Technology -

Awards and Honors

  • Korean government scholarship for Graduate Study, Scholarship/Research
  • McMaster University Scholarship, Scholarship/Research - McMaster University
  • Yonsei University Journalism Scholarship, Scholarship/Research
  • Travel Award (2012) - CCE XIII
  • Travel Award (2012) - CPC VIII
  • CTTS Annual Retreat Best Poster Award (2011) - UMass Medical
  • Sherman Scholarship for excellent teaching & research (1999), Scholarship/Research - McMaster Univ
  • Korean-Canadian Scholarship Foundation, Canada (1997), Scholarship/Research
  • Excellent Engineer Award of the Year, Hyundai Petrochemical Co. (1995), Service, Professional


  • Bhatia, H., Read, E., Agarabi, C., Brorson, K., Lute, S., Yoon, S. (2016) "A design space exploration for control of critical quality attributes of mAb," International Journal of Pharmaceutics 512:1 pp. 242–252
  • Reimonn, T.M., Park, S., Agarabi, C.D., Brorson, K.A., Yoon, S. (2016) "Effect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures—Systems biology-based interpretation using genome-scale metabolic flux balance model and multivariate data analysis," Biotechnology Progress 32:5 pp. 1163–1173
  • Sha, S., Zhuangrong, H., Agarabi, C., Lute, S., Brorson, K., Yoon, S. () "Estimation and control of N-linked glycoform profiles of monoclonal antibody with extracellular metabolites and two-step intracellular model," Biotechnology and Bioengineering
  • Behere, K., Canning, V., Kauten, J., Hadley, B., Beri, R., Heimback, J., Gerber, R., Yoon, S. () "Evaluation of a Glycosylation Control Strategy for Monoclonal Antibodies through an Integrated Experimental and Statistical Approach," Biotechnology and Bioengineering
  • Bhatia, H., Read, E., Agarabi, C., Brorson, K., Lute, S., Yoon, S. (2016) "Hybridoma cell-culture and glycan profile dataset at various bioreactor conditions," Data in brief 9: pp. 676–678
  • Kamga, M., Roper, T., Padye, S., Li, Y., , Yoon, S. () "Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation," Biotechnology Journal
  • Galbraith, S.C., Bittorf, K., Yoon, S., Meyer, R., Falmm, M., Hurley, S., Liu, H., Li, M. () "Modeling and simulation of continuous powder blending applied to a continuous direct compression process," International Journal of Pharmaceutics
  • Sha, S., Agarabi, C., Brorson, K., Lee, D., Yoon, S. (2016) "N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies," Trends in biotechnology
  • Behere, K., B, C., Yoon, S. () "Protein A resin lifetime study: evaluation of protein A performance with a model based approach in continuous capture," Biotechnology Progress
  • Bhatia, H., Mehdizadeh, H., Drapeau, D., Yoon, S., Moshgbar, M. () "Quantitation of Amino Acids in Cell Cultures using Raman Spectrosc," Biotechnology Progress
  • Trunfio, N., Christie, A., Lee, H., Yoon, S. () "Raw Material Characterization of Mammalian Cell Cultures using Spectroscopic Methodologies and Chemometrics," Biotechnology Progress
  • Sha, S., Yoon, S. (2016) "Real time prediction and control of glycoform profile of mammalian cell cultures using in silico glycosylation model coupled with extracellular metabolites,"
  • Huang, Z., Lee, D., Yoon, S. () "Review on metabolic flux analysis in biotherapeutic development and manufacturing," Biotechnology and Bioengineering
  • Liu, H., Galbraith, S., Cha, B., Huang, Z., Park, S., Meyer, R., Flamm, M., O'Connor, T., Lee, S., Yoon, S. () "Three-compartmental population balance model for a continuous twin screw wet granulation process: model development and validation," International Journal of Pharmaceutics
  • Liu, H., Yoon, S., Li, M. () "Three-Dimensional Computational Fluid Dynamics (CFD) Study of the Gas-Particle Circulation Pattern Within a Fluidized Bed Granulator: By Full-Factorial Design of Fluidization Velocity and Particle Size," Drying Technology
  • Shah, P.N., Kim, N., Huang, Z., Jayamanna, M., Kokil, A., Pine, A., Kaltsas, J., Jahngen, E.G., Ryan, D.K., Yoon, S., Kovar, R.F., Lee, Y. (2015) "Environmentally benign synthesis of vinyl ester resin from biowaste glycerin," RSC Adv. 5:48 pp. 38673-38679
  • Lee, H.W., Christie, A., Starkey, J.A., Read, E.K., Yoon, S. (2015) "Intracellular metabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell-growth," Journal of Chemical Technology and Biotechnology 90:2 pp. 291–302
  • Park, D.H., Jeon, H.S., Lee, S.Y., Choi, Y.Y., Lee, H.W., Yoon, S., Lee, J.C., Yoon, Y.S., Kim, D.S., Na, M.J., Kwon, S.J., Kim, D.S., Kang, J., Park, J.Y., Son, J.W. (2015) "MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2," International journal of oncology 47: pp. 1545+
  • Yoon, S. (2014) "Basic principles and application trend of Quality By Design,"
  • Rathore, A., Calado, C., Gernaey, K., Yoon, S. (2014) "Editorial of special issues on Process Analytical Technology," Journal of Chemical Technology and Biotechnology
  • Kamga, M., Lee, H., Yoon, S. (2014) "Modeling of protein monomer/aggregate purification by hydrophobic interaction chromatography: application to column design and process optimization,"
  • Lee, H., Christie, A., Starkey, J., Read, E., Yoon, S. (2014) "Intracellular matabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell-growth," Journal of Chemical Technology and Biotechnology
  • Lee, H., Carvell, J., Brorson, K., Yoon, S. (2014) "Dielectric spectroscopy-based estimation of VCD in CHO cell culture," Journal of Chemical Technology and Biotechnology
  • Yousefian Jazi, A., Ryu, J., Yoon, S., Liu, J. (2014) "Decision support in machine vision system for monitoring of TFT-LCD glass substrates manufacturing," Journal of Process Control 24:6 pp. 1015-1023
  • Yoon, S. (2013) "Foreword," Journal of Pharmaceutical Bioprocessing 1:1 pp. 1-2
  • Yoon, S. (2013) "Globalization strategy of Korean U-Health Industry via Case Study on Norht American U-Health Industry," Korea Institute of S&T Evaluation and Planning
  • Bawn, A., Lee, H., Downey, A., Xu, J., Yoon, S. (2013) "Metabolic-Sensing Characteristics of Absorption-Photometry for Mammalian Cell Cultures in Biopharmaceutical Processes," Journal of Pharmaceutical Bioprocessing 1:3 pp. 255-266
  • Kamga, M., Lee, H., Liu, J., Yoon, S. (2013) "Quantification of Protein Mixture in chromatographic separation using Multi-wavelength UV spectra," Biotechnology Progress 29:3 pp. 664-71
  • Lee, H., Lawton, C., Na, Y., Yoon, S. (2013) "Robustness of Chemometrics-based Feature Selection Methods in Early Cancer Detection and Biomarker Discovery," Statistical Application in Genetics and Molecular Biology 12:2 pp. 207-223
  • Bhoskar, P., Belongia, B., Smith, R., Yoon, S., Carter, T., Xu, J. (2013) "Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality," Biotechnology Progress 29:5 pp. 1131-1139
  • Yoon, S., Lee, H., Liu, J. (2013) "Quality characterization and classification of engineered stone countertops using a soft-sensor based on image analysis," Industrial and Engineering Chemistry Research 52:35 pp. 12337-12345
  • Kamga, M., Woo Lee, H., Liu, J., Yoon, S. (2013) "Quantification of protein mixture in chromatographic separation using multi-wavelength UV spectra," Biotechnology Progress 29:3 pp. 664-671
  • Lee, H., Lawton, C.W., Na, Y., Yoon, S. (2013) "Robustness of chemometrics-based feature selection methods in early cancer detection and biomarker discovery," Statistical Applications in Genetics and Molecular Biology 12:2 pp. 207-223
  • Yousefian Jazi, A., Yoon, S., Liu, J.J., . (2012) "Automatic grading of TFT-LCD glass substrates using optimized support vector machines," Industrial and Engineering Chemistry Research 51:33 pp. 10887-10894
  • Lee, H.W., Christie, A., Xu, J., Yoon,, ., S., . (2012) "Data fusion-based assessment of raw materials in mammalian cell culture," Biotechnology and Bioengineering 109:11 pp. 2819-2828
  • Lee, H.W., Christie, A., Liu, J.J., Yoon, S. (2012) "Estimation of raw material performance in mammalian cell culture using near infrared spectra combined with chemometrics approaches," Biotechnology progress 28:3
  • Lee, H.W., Bawn, A., Yoon, S., . (2012) "Reproducibility, complementary measure of predictability for robustness improvement of multivariate calibration models via variable selections," Analytica Chimica Acta 757: pp. 11-18


  • Flowsheet Modeling Of A Continuous Direct Compression Tableting Process At Production Scale - Focapo-Cpc 2017, 2017 - Tucson, Arizona, USA
  • Online Optimization Of A Top-Spray Fluidized Bed Granulation Process Based On A Three-Stage Population Balance Model - Focapo-Cpc 2017, 2017 - Tucson, Arizona, USA
  • Real time prediction and control of glycoform profile of mammalian cell cultures using in silico glycosylation model coupled with extracellular metabolites - Cell Culture Engineering XV, 2016

Contracts, Fellowships, Grants and Sponsored Research

  • Biopharmaceutical Fund (2012), Grant - Multiple Institutes
    Yoon, S.
  • NSF IGERT (), Grant - NSF
    Yoon, S.
  • CAREER: Batch process control of monoclonal antibody product in suspension cultured mammalian cells - microscopic and macroscopic modeling approachesion/xam (), Grant - NSF
    Yoon, S.
  • Omics based BIGDATA analytics for biologics development (2013), Grant - NSF CDS&E CBET/BBBE
    Yoon, S.
  • GPIbalpha: a Blood Biomarker for Early Diagnosis of AlzheimerÍs Disease (), Grant - DOD (MRPRA)
    Yoon, S.
  • Acquisition of a Next Generation Sequencing System for Genomics Research and Training at the University of Massachusetts Lowell (2013), Grant - NSF MRI
    Yoon, S.
  • Innovative Analytics Platform for Biologics Development (2013), Grant - MLSC Cooperate Matching Fund
    Yoon, S.
  • Biopharmaceutical Process and Quality Consortium (BPQC) (2012), -
    Yoon, S. (Principal)
  • Endotoxin Detector for Global Microbiological and Clinical Market Sectors (), Grant - NSF
    Yoon, S.
  • PFI/BIC:Integrated biosensing technologies for biopharmaceutical development and manufacturing via university and industry consortium (), Grant - NSF
    Yoon, S.
  • Regulatory sciences (), Grant - NIH
    Yoon, S.
  • Sparging Visualization (2013), -
    Yoon, S. (Principal)
  • PSM Program Development (2013), -
    Yoon, S. (Principal)
  • PSM Program Development (2013), -
    Yoon, S. (Principal)
  • Summer Research Student (2013), -
    Yoon, S. (Principal)
  • Investigate At-Line Trace Metal Analysis Technology (2012), -
    Yoon, S. (Principal)
  • IEF and 2D SDA-PAGE Assay Development (2013), -
    Yoon, S. (Principal)
  • Income Account for Analytical Test and Data Informatics (2013), -
    Yoon, S. (Principal)
  • Modeling population dynamics of breast cancer stem cells using Raman spectra (), Grant - NIH
    Yoon, S.
  • U-Health Industry Review (2013), -
    Yoon, S. (Principal)
  • At-Line Trace Metal Analysis and Method Development (2012), -
    Yoon, S. (Principal)
  • Develop Medical Optimization Methodology (2012), -
    Yoon, S. (Principal)
  • Media optimization Cell cultureæ (2012), Grant - the University
    Yoon, S.
  • BPQC Membership (2012), Grant -
    Yoon, S.
  • Trace metal analysis in Cell culture (2012), Grant - the University
    Yoon, S.
  • Trace metal variability analysis (2012), Grant - Vertex Pharmaceutical
    Yoon, S.
  • New Faculty Start-up Fund (2010), Contract -
    Yoon, S.
  • Massachusetts Life Science Center (2010), Grant -
    Yoon, S. (Co-Principal)
  • CCE XIII 2012 Travel Award (2012), Grant -
    Yoon, S.
  • CPC VIII 2012 Travel Awards (2012), Grant -
    Yoon, S., Lee, H.
  • Wheat Hydrolysate Analysis (2012), - SAFC
    Yoon, S.
  • Feasibility of Cedex Bio (2011), Grant - Roche Diagnostics
    Yoon, S.
  • Harmonizing viable cell density measurement for CHO batch processes (2011), Grant - Aber Instruments (UK)
    Yoon, S.
  • Biopharmaceutical Consortium (2011), - UMass President S&T
    Yoon, S.
  • Harmonizing Viable Cell Density Measurement for CHO Batch Processes Determined by (2011), -
    Yoon, S. (Principal)
  • Wheat Hydrolysate Analysis (2012), -
    Yoon, S. (Principal)
  • Feasibility Study of Cedex Bio (2011), -
    Yoon, S. (Principal)
  • (2011), Grant - Chromworks
    Yoon, S.
  • Roche Diagnostics (2011), Grant -
    Yoon, S.
  • New Brunswick (), -
    Yoon, S.
  • Toxic Use Reduction Institute (2010), - Toxic Use Reduction Institute (TURI)
    Yoon, S.