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Seongkyu Yoon

Seongkyu Yoon
Seongkyu YoonAssistant Professor, Director
  • CollegeFrancis College of Engineering
  • DepartmentChemical Engineering
  • Phone(978) 934-4741
  • EmailSeongkyu_Yoon@uml.edu

Research Interests

Process system engineering; Systems Biotechnology; Regulatory Sciences; Biomanufacturing Innovation

Process Analytical Technology (PAT) and Quality By Design (QbD) Application of experimental design and multivariate data analysis in biopharmaceuticals Supply chain management in biologics; and Chemometrics in life sciences

Education

  • MBA, (), Babson College - Wellesley MA
  • Ph D: Chemical Engineering, (2001), McMaster University - Hamilton, Canada
    Dissertation/Thesis Title: Using External Information for Statistical Process Control
  • MS: Chemical and Biomolecular Engineering, (1990), Korea Advanced Institute of Science and Technology - Daejon, Korea
    Dissertation/Thesis Title: "Constrained multivariable Model Algorithmic Control and its Non-Minimum Phase Characteristics."
  • BS: Chemical Engineering, (1988), Yonsei University - Seoul, Korea

Awards and Honors

  • Ward Chaired Professor of Biomedical Material Sciences (2016)

Publications

  • Galbraith, S.C., Huang, Z., Cha, B., Liu, H., Hurley, S., Flamm, M.H., Meyer, R.J. , ., Yoon, S. (2017) "Flowsheet Modeling Of A Continuous Direct Compression Tableting Process At Production Scale," ID: 46
  • Huolong Liu, Shaun Galbraith, Bumjoon Cha, Zhuangrong Huang, Seoyoung Park, ., Yoon, S. (2017) "Online Optimization Of A Top-Spray Fluidized Bed Granulation Process Based On A Three-Stage Population Balance Model," ID: 55
  • Bhatia, H., Read, E., Agarabi, C., Brorson, K., Lute, S., Yoon, S. (2016) "A design space exploration for control of critical quality attributes of mAb," International Journal of Pharmaceutics 512:1 pp. 242–252
  • Reimonn, T.M., Park, S., Agarabi, C.D., Brorson, K.A., Yoon, S. (2016) "Effect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures—Systems biology-based interpretation using genome-scale metabolic flux balance model and multivariate data analysis," Biotechnology Progress 32:5 pp. 1163–1173
  • Sha, S., Zhuangrong, H., Agarabi, C., Lute, S., Brorson, K., Yoon, S. () "Estimation and control of N-linked glycoform profiles of monoclonal antibody with extracellular metabolites and two-step intracellular model," Biotechnology and Bioengineering
  • Behere, K., Canning, V., Kauten, J., Hadley, B., Beri, R., Heimback, J., Gerber, R., Yoon, S. () "Evaluation of a Glycosylation Control Strategy for Monoclonal Antibodies through an Integrated Experimental and Statistical Approach," Biotechnology and Bioengineering
  • Bhatia, H., Read, E., Agarabi, C., Brorson, K., Lute, S., Yoon, S. (2016) "Hybridoma cell-culture and glycan profile dataset at various bioreactor conditions," Data in brief 9: pp. 676–678
  • Kamga, M., Roper, T., Padye, S., Li, Y., , Yoon, S. () "Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation," Biotechnology Journal
  • Galbraith, S.C., Bittorf, K., Yoon, S., Meyer, R., Falmm, M., Hurley, S., Liu, H., Li, M. () "Modeling and simulation of continuous powder blending applied to a continuous direct compression process," International Journal of Pharmaceutics
  • Sha, S., Agarabi, C., Brorson, K., Lee, D., Yoon, S. (2016) "N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies," Trends in biotechnology
  • Behere, K., B, C., Yoon, S. () "Protein A resin lifetime study: evaluation of protein A performance with a model based approach in continuous capture," Biotechnology Progress
  • Bhatia, H., Mehdizadeh, H., Drapeau, D., Yoon, S., Moshgbar, M. () "Quantitation of Amino Acids in Cell Cultures using Raman Spectrosc," Biotechnology Progress
  • Trunfio, N., Christie, A., Lee, H., Yoon, S. () "Raw Material Characterization of Mammalian Cell Cultures using Spectroscopic Methodologies and Chemometrics," Biotechnology Progress
  • Sha, S., Yoon, S. (2016) "Real time prediction and control of glycoform profile of mammalian cell cultures using in silico glycosylation model coupled with extracellular metabolites,"
  • Huang, Z., Lee, D., Yoon, S. () "Review on metabolic flux analysis in biotherapeutic development and manufacturing," Biotechnology and Bioengineering
  • Liu, H., Galbraith, S., Cha, B., Huang, Z., Park, S., Meyer, R., Flamm, M., O'Connor, T., Lee, S., Yoon, S. () "Three-compartmental population balance model for a continuous twin screw wet granulation process: model development and validation," International Journal of Pharmaceutics
  • Liu, H., Yoon, S., Li, M. () "Three-Dimensional Computational Fluid Dynamics (CFD) Study of the Gas-Particle Circulation Pattern Within a Fluidized Bed Granulator: By Full-Factorial Design of Fluidization Velocity and Particle Size," Drying Technology
  • Shah, P.N., Kim, N., Huang, Z., Jayamanna, M., Kokil, A., Pine, A., Kaltsas, J., Jahngen, E.G., Ryan, D.K., Yoon, S., Kovar, R.F., Lee, Y. (2015) "Environmentally benign synthesis of vinyl ester resin from biowaste glycerin," RSC Adv. 5:48 pp. 38673-38679
  • Lee, H.W., Christie, A., Starkey, J.A., Read, E.K., Yoon, S. (2015) "Intracellular metabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell-growth," Journal of Chemical Technology and Biotechnology 90:2 pp. 291–302
  • Park, D.H., Jeon, H.S., Lee, S.Y., Choi, Y.Y., Lee, H.W., Yoon, S., Lee, J.C., Yoon, Y.S., Kim, D.S., Na, M.J., Kwon, S.J., Kim, D.S., Kang, J., Park, J.Y., Son, J.W. (2015) "MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2," International journal of oncology 47: pp. 1545+
  • Yoon, S. (2014) "Basic principles and application trend of Quality By Design,"
  • Rathore, A., Calado, C., Gernaey, K., Yoon, S. (2014) "Editorial of special issues on Process Analytical Technology," Journal of Chemical Technology and Biotechnology
  • Kamga, M., Lee, H., Yoon, S. (2014) "Modeling of protein monomer/aggregate purification by hydrophobic interaction chromatography: application to column design and process optimization,"
  • Lee, H., Christie, A., Starkey, J., Read, E., Yoon, S. (2014) "Intracellular metabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell-growth," Journal of Chemical Technology and Biotechnology
  • Lee, H., Carvell, J., Brorson, K., Yoon, S. (2014) "Dielectric spectroscopy-based estimation of VCD in CHO cell culture," Journal of Chemical Technology and Biotechnology
  • Yousefian Jazi, A., Ryu, J., Yoon, S., Liu, J. (2014) "Decision support in machine vision system for monitoring of TFT-LCD glass substrates manufacturing," Journal of Process Control 24:6 pp. 1015-1023
  • Yoon, S. (2013) "Foreword," Journal of Pharmaceutical Bioprocessing 1:1 pp. 1-2
  • Yoon, S. (2013) "Globalization strategy of Korean U-Health Industry via Case Study on North American U-Health Industry," Korea Institute of S&T Evaluation and Planning
  • Bawn, A., Lee, H., Downey, A., Xu, J., Yoon, S. (2013) "Metabolic-Sensing Characteristics of Absorption-Photometry for Mammalian Cell Cultures in Biopharmaceutical Processes," Journal of Pharmaceutical Bioprocessing 1:3 pp. 255-266
  • Kamga, M., Lee, H., Liu, J., Yoon, S. (2013) "Quantification of Protein Mixture in chromatographic separation using Multi-wavelength UV spectra," Biotechnology Progress 29:3 pp. 664-71
  • Lee, H., Lawton, C., Na, Y., Yoon, S. (2013) "Robustness of Chemometrics-based Feature Selection Methods in Early Cancer Detection and Biomarker Discovery," Statistical Application in Genetics and Molecular Biology 12:2 pp. 207-223
  • Bhoskar, P., Belongia, B., Smith, R., Yoon, S., Carter, T., Xu, J. (2013) "Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality," Biotechnology Progress 29:5 pp. 1131-1139
  • Yoon, S., Lee, H., Liu, J. (2013) "Quality characterization and classification of engineered stone countertops using a soft-sensor based on image analysis," Industrial and Engineering Chemistry Research 52:35 pp. 12337-12345
  • Kamga, M., Woo Lee, H., Liu, J., Yoon, S. (2013) "Quantification of protein mixture in chromatographic separation using multi-wavelength UV spectra," Biotechnology Progress 29:3 pp. 664-671
  • Lee, H., Lawton, C.W., Na, Y., Yoon, S. (2013) "Robustness of chemometrics-based feature selection methods in early cancer detection and biomarker discovery," Statistical Applications in Genetics and Molecular Biology 12:2 pp. 207-223
  • Yousefian Jazi, A., Yoon, S., Liu, J.J., . (2012) "Automatic grading of TFT-LCD glass substrates using optimized support vector machines," Industrial and Engineering Chemistry Research 51:33 pp. 10887-10894
  • Lee, H.W., Christie, A., Xu, J., Yoon,, ., S., . (2012) "Data fusion-based assessment of raw materials in mammalian cell culture," Biotechnology and Bioengineering 109:11 pp. 2819-2828
  • Lee, H.W., Christie, A., Liu, J.J., Yoon, S. (2012) "Estimation of raw material performance in mammalian cell culture using near infrared spectra combined with chemometrics approaches," Biotechnology progress 28:3
  • Lee, H.W., Bawn, A., Yoon, S., . (2012) "Reproducibility, complementary measure of predictability for robustness improvement of multivariate calibration models via variable selections," Analytica Chimica Acta 757: pp. 11-18

Presentations

  • Flowsheet Modeling Of A Continuous Direct Compression Tableting Process At Production Scale - Focapo-Cpc 2017, 2017 - Tucson, Arizona, USA
  • Online Optimization Of A Top-Spray Fluidized Bed Granulation Process Based On A Three-Stage Population Balance Model - Focapo-Cpc 2017, 2017 - Tucson, Arizona, USA
  • Real time prediction and control of glycoform profile of mammalian cell cultures using in silico glycosylation model coupled with extracellular metabolites - Cell Culture Engineering XV, 2016

Contracts, Fellowships, Grants and Sponsored Research

  • Biopharmaceutical Fund (2012), Grant - Multiple Institutes
    Yoon, S.
  • Acquisition of a Next Generation Sequencing System for Genomics Research and Training at the University of Massachusetts Lowell (2013), Grant - NSF MRI
    Yoon, S.