Expertise
Medicinal Chemistry, Machine Learning, Chemical Biology, Model-Informed Drug Discovery and Development.
Research Interests
Hammouda's research combines model-informed drug discovery, medicinal chemistry, and machine learning to target historically undruggable proteins, from disordered domains to cryptic pockets and protein–protein interfaces. His lab at UMass Lowell integrates computational prediction with rigorous experimental validation to accelerate the path from target identification to precision therapeutics for cancer, neurodegenerative disease, and other conditions with significant unmet need.
Education
- Doctor of Philosophy (Ph.D.) Medicinal Chemistry - Dongguk University, South Korea.
- Master of Science (M.S.) Pharmaceutical Science - Cairo University, Egypt
- Bachelor of Science (B.S.) Pharmacy - Cairo University, Egypt
Biosketch
Hossam Hammouda, Ph.D. is an assistant professor of pharmaceutical science in the department of biomedical and nutritional sciences at the University of Massachusetts Lowell. His research integrates medicinal chemistry, chemical biology, and machine learning to discover precision therapeutics for biologically challenging, historically undruggable targets. He has developed and prospectively validated open-source machine learning platforms for screening prioritization, de novo ligand design, and target engagement prediction, contributing to the discovery of several first-in-class small-molecule therapeutics with applications spanning oncology and neurodegenerative disease. Prior to UMass Lowell, he was a postdoctoral associate at Weill Cornell Medicine, where he led computational and experimental drug discovery campaigns integrating structural biology, biophysics, and pharmacology. He earned his Ph.D. in medicinal chemistry from Dongguk University in Seoul, South Korea, and his M.S. in pharmaceutical chemistry and B.S. in pharmacy from Cairo University, Egypt. His work has been recognized with the Research Excellence Award from Dongguk University and multiple Best Academic Performance Awards from the Korean government's Ministry of Education