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Melisenda McDonald


Melisenda Jean McDonald
Melisenda J. McDonaldProfessor Emeritus

Research Interests

Biochemistry

Protein structure, function and assembly; hemoglobin; self-assembled protein systems; structural biology; immunobiochemistry; biosensor technology; self-mediated biosystems.

Education

  • Ph D: Biochemistry, (1973), State University of New York - Buffalo, New York
  • Ph D: Biochemistry, (1973), State University of New York - Buffalo, NY
  • MA: Biochemistry, (1971), State University of New York - Buffalo, New York
  • MA: Biochemistry, (1971), State University of New York - Buffalo, NY
  • BA: Biology/Chemistry, (1967), Dowling College - Oakdale, NY
  • BA: Biology/Chemistry, (1967), Dowling College - Oakdale, New York

Selected Awards and Honors

  • Editorial Board Member: Current Protein and Peptide Science - The Open Biochemistry Journal
  • Excellence in Teaching Award in Chemistry, Teaching - University of Massachusetts Lowell
  • Research Career Development Award - National Institutes of Health
  • Excellence in Teaching Award (2009) - UML
  • Editorial Board Member: The Open Biochemistry Journal (2007)
  • Editorial Board Member: Current Protein and Peptide Science (2004)
  • Excellence in Teaching Award (2004) - UML
  • Sigma Xi (2001)
  • Research Career Development Award (1982) - National Heart, Lung and Blood Institute, National Institutes of Health

Selected Publications

  • Farris, L.R., McDonald, M.J. (2012) "Computational analysis of non-covalent polymer-protein interactions governing antibody orientation", Analytical and Bioanalytical Chemistry 402:4 pp. 1731-1736
  • Patil, S., Chaudhury, P., Clarizia, L., McDonald, M.J., Reynaud, E., Gaines, P., Schmidt, D.F. (2012) "Responsive hydrogels produced via organic sol-gel chemistry for cell culture applications", Acta Biomaterialia 8:8 pp. 2919-2931
  • Farris, L.R., McDonald, M.J. (2011) "AFM imaging of ALYGNSA polymer-protein surfaces: Evidence of antibody orientation", Analytical and Bioanalytical Chemistry 401:9 pp. 2821-2829
  • Chourb, S., Mackness, B.C., Farris, L.R., McDonald, M.J. (2011) "Improved detection of the MUC1 cancer antigen CA 15-3 by ALYGNSA fluorimmunoassay", Health 3:8 pp. 524-528
  • Patil, S., Clarizia, L.J., McDonald, M.J., Reynaud, E., Schmidt, D.F. (2011) "Responsive hydrogels produced via organic sol-gel chemistry for biomedical applications", Annual Technical Conference - Society of Plastics Engineers 69th: pp. 2012-2016
  • Farris, L.R., Wu, N., Wang, W., Clarizia, L.J., Wang, X., McDonald, M.J. (2010) "Immuno-interferometric sensor for the detection of influenza A nucleoprotein", Analytical and Bioanalytical Chemistry 396:2 pp. 667-674
  • Wu, N., Wang, W., Ling, Y., Farris, L., Kim, B., McDonald, M.J., Wang, X. (2010) "Label-free detection of biomolecules using LED technology", Proceedings of SPIE 7574: pp. 75740-75740
  • MacKness, B.C., Chourb, S., Farris, L.R., McDonald, M.J. (2010) "Polymer-protein-enhanced fluoroimmunoassay for prostate-specific antigen", Analytical and Bioanalytical Chemistry 396:2 pp. 681-686
  • MacKness, B.C., McDonald, M.J. (2010) "Serum-based ALYGNSA immunoassay for the prostate cancer biomarker, total prostate-specific antigen (tPSA)", Analytical and Bioanalytical Chemistry 397:7 pp. 3151-3154
  • Ling, Y., Wu, N., Wang, W., Farris, L.R., Kim, B., Wang, X., McDonald, M.J. (2010) "Thin Film Thickness Variation Measurement Using Dual LEDs and Reflectometric Interference Spectroscopy Model in Biosensor SPIE Photonics West BiOS Exhibition: Optical Fibers and Sensors Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications;", Proceedings of SPIE 75590K
  • Clarizia, L.A., Sok, D., Wei, M., Mead, J., Barry, C., McDonald, M.J. (2009) "Antibody orientation enhanced by selective polymer-protein noncovalent interactions", Analytical and bioanalytical chemistry 393:5 pp. 1531-8
  • Chourb, S., Mackness, B.C., Farris, L.R., McDonald, M.J. (2009) "Enhanced Immuno-Detection of Shed Extracellular Domain of HER-2/neu;", HEALTH 1: pp. 325-329
  • Wu, N., Wang, W., Farris, L.R., McDonald, M.J., Wang, X. (2009) "Label-free Detection of Biomolecules Using an Optical Biosensor", The Fifth International Workshop on Advanced Smart Material and Smart Structures Technology pp. 644-649
  • Sok, D., Clarizia, L.J., Farris, L.R., McDonald, M.J. (2009) "Novel fluoroimmunoassay for ovarian cancer biomarker CA-125", Analytical and Bioanalytical Chemistry 393:5 pp. 1521-1523
  • Wang, W., Ma, X., Clarizia, L.J., Wang, X., McDonald, M.J. (2009) "Optical Interferometric Biosensor with PMMA as Functional Layer", Materials Research Society Symposium Proceedings 1133: pp. 0-3
  • Fonseka, P.V., Vasudevan, G., Clarizia, L.J., McDonald, M.J. (2007) "Temperature dependent soret spectral band shifts accompany human CN-mesohemoglobin assembly", Protein Journal 26:4 pp. 257-263
  • Vasudevan, G., McDonald, M.J. (2006) "Soret spectral and bioinformatic approaches provide evidence for a critical role of the -subunit in assembly of tetrameric hemoglobin", Protein Journal 25:1 pp. 45-56
  • Claypool, K., Vasudevan, G., McDonald, M.J. (2004) "Promethea: Building an integrated community of protein resources on the Web", Faseb Journal 18:8
  • Vasudevan, G., Fonseka, P., McDonald, M.J. (2004) "Temperature dependent Soret spectral changes accompany CNHemin binding to apohemoglobin", Faseb Journal 18:8
  • Morris, A., McDonald, M.J. (2002) "Carboxyl-terminal modification alters the subunit interactions and assembly pathways of normal and sickle hemoglobins", Journal of protein chemistry 20:8 pp. 611-617
  • Jennings, T.M., McDonald, M.J. (2002) "Esterification of the propionate groups promotes / hemoglobin chain homogeneity of CN-hemin binding", Biochemical and biophysical research communications 293:5 pp. 1354-1357
  • Vasudevan, G., McDonald, M.J. (2002) "Ordered heme binding ensures the assembly of fully functional hemoglobin: A hypothesis", Current Protein and Peptide Science 3:4 pp. 461-466
  • Morris, A., McDonald, M.J. (2001) "Carboxyl-terminal modification alters the subunit interactions and assembly pathways of normal and sickle hemoglobins", Journal of protein chemistry 20:8 pp. 611-617
  • Adachi, K., Yang, Y., Joshi, A.A., Vasudevan, G., Morris, A., McDonald, M.J. (2001) "Consequence of 16 and 112 replacements on the kinetics of hemoglobin assembly", Biochemical and biophysical research communications 289:1 pp. 75-79
  • McDonald, M.J., Morris, A., Vasudevan, G. (2000) "Carboxyl-terminal modification alters the subunit interactions and assembly pathways of HbA and HbS.", Faseb Journal 14:8
  • Chiu, F., Vasudevan, G., Morris, A., McDonald, M.J. (2000) "Soret spectroscopic and molecular graphic analysis of human semi- -hemoglobin formation", Protein Journal 19:2 pp. 157-162
  • Yamaguchi, T., Yang, Y., McDonald, M.J., Adachi, K. (2000) "Surface and interface -chain residues synergistically affect hemoglobin assembly", Biochemical and biophysical research communications 270:3 pp. 683-687
  • Vasudevan, G., McDonald, M.J. (2000) "Wavelength-dependent spectral changes accompany CN-hemin binding to human apohemoglobin", Journal of protein chemistry 19:7 pp. 583-590
  • Vasudevan, G., McDonald, M.J. (1998) "Analysis of the global architecture of hemoglobin A2 by heme binding studies and molecular modeling", Protein Journal 17:4 pp. 319-327
  • Chiu, F., Vasudevan, G., Morris, A., McDonald, M.J. (1998) "Fluorescence studies of human semi- -hemoglobin assembly", Biochemical and biophysical research communications 242:2 pp. 365-368
  • Vasudevan, G., McDonald, M.J. (1997) "Spectral demonstration of semihemoglobin formation during CN-hemin incorporation into human apohemoglobins", Journal of Biological Chemistry 272:1 pp. 517-524
  • Moulton, D.P., Morris, A., Vasudevan, G., Chiu, F.M., McDonald, M.J. (1996) "Carboxyl-terminal modification influences subunit assembly of sickle hemoglobin beta chains", Biochemical and biophysical research communications 226:2
  • Moulton, D.P., Joshi, A.A., Morris, A., McDonald, M.J. (1994) "Effect of Carboxyterminal Modification on the Oligomeric Structure of Human Beta-Hemoglobin", Biochemical and biophysical research communications 204:2
  • O'Malley, S.M., McDonald, M.J. (1994) "Fluorescence studies of normal and sickle beta apohemoglobin self- association", Journal of protein chemistry 13:7 pp. 585-590
  • Omalley, S.M., McDonald, M.J. (1994) "Fluorescence Studies of Normal and Sickle Beta-Apohemoglobin Self-Association", Journal of protein chemistry 13:7
  • Moulton, D.P., McDonald, M.J. (1994) "Kinetics of Human Apohemoglobin Dimer Dissociation", Biochemical and biophysical research communications 199:3
  • O'Malley, S.M., McDonald, M.J. (1994) "Monitoring the effect of subunit assembly on the structural flexibility of human alpha apohemoglobin by steady-state fluorescence", Journal of protein chemistry 13:6 pp. 561-567
  • Omalley, S.M., McDonald, M.J. (1994) "Monitoring the Effect of Subunit Assembly on the Structural Flexibility of Human Alpha-Apohemoglobin by Steady-State Fluorescence", Journal of protein chemistry 13:6
  • Wei, Y.Z., Kumbharkhane, A.C., Sadeghi, M., Sage, J.T., Tian, W.D., Champion, P.M., Sridhar, S., McDonald, M.J. (1994) "Protein hydration investigations with high-frequency dielectric spectroscopy", Journal of Physical Chemistry 98:26 pp. 6644-6651
  • Joshi, A.A., McDonald, M.J. (1994) "Role of and carboxyl-terminal residues in the kinetics of human oxyhemoglobin dimer assembly", Journal of Biological Chemistry 269:11 pp. 8549-53
  • Joshi, A.A., McDonald, M.J. (1994) "Role of and carboxyl-terminal residues in the kinetics of human oxyhemoglobin dimer assembly", Journal of Biological Chemistry 269:11 pp. 8549-8553
  • Joshi, A.A., McDonald, M.J. (1994) "Role of Alpha-Carboxyl-Terminal and Beta-Carboxyl-Terminal Residues in the Kinetics of Human Oxyhemoglobin Dimer Assembly", Journal of Biological Chemistry 269:11
  • O'Malley, S.M., McDonald, M.J. (1994) "Steady state fluorescence energy transfer measurements of human alpha apohemoglobin structure", Biochemical and biophysical research communications 200:1 pp. 384-388
  • Omalley, S.M., McDonald, M.J. (1994) "Steady-State Fluorescence Energy-Transfer Measurements of Human Alpha-Apohemoglobin Structure", Biochemical and biophysical research communications 200:1
  • Moulton, D.P., McDonald, M.J. (1993) "Rate of Dissociation of the Human Apohemoglobin Dimer", Biophysical journal 64:2
  • Moopenn, W.F., Hine, T.K., Johnson, M.H., Jue, D.L., Holland, S., George, S., Pierce, A.M., Michalski, L.A., McDonald, M.J. (1992) "Hb Rancho Mirage [Beta-143(h21)his-]Asp] - a Variant in the 2,3-Dpg Binding-Site Showing Normal Oxygen-Affinity at Physiological Ph", Hemoglobin 16:1-2
  • Omalley, S.M., McDonald, M.J. (1992) "Intrinsic Tryptophanyl Fluorescence Properties of Human Normal and Sickle Beta Apohemoglobin are Concentration Dependent", Faseb Journal 6:1
  • Joshi, A.A., McDonald, M.J. (1992) "The Effect of Carboxyterminal Modification on the Kinetics of Human Oxyhemoglobin Assembly", Faseb Journal 6:1
  • McDonald, M.J., Michalski, L.A., Turci, S.M., Guillette, R.A., Jue, D.L., Johnson, M.H., Moo-Penn, W.F. (1990) "Structural, functional, and subunit assembly properties of hemoglobin Attleboro [ 138 (H21) Ser Pro], a variant possessing a site mutation at a critical C-terminal residue", Biochemistry 29:1 pp. 173-178
  • Omalley, S.M., McDonald, M.J. (1990) "The Effect of Ph on the Structure of Alpha-Apohemoglobin Measured by Steady-State Fluorescence Energy-Transfer", Biophysical journal 57:2
  • Youl Park, R., McDonald, M.J. (1989) "Kinetics of heme binding to semi-alpha-hemoglobin", Biochemical and biophysical research communications 162:1 pp. 522-527
  • Park, R.Y., McDonald, M.J. (1989) "Kinetics of Heme Binding to Semi-Alpha-Hemoglobin", Biochemical and biophysical research communications 162:1
  • Michalski, L.A., McDonald, M.J. (1988) "An investigation of human oxyhemoglobin beta tetramer dissociation using haptoglobin binding", Biochemical and biophysical research communications 156:1 pp. 438-444
  • McDonald, M.J., Turci, S.M., Michalski, L.A. (1988) "The Kinetics of Human Oxyhemoglobin Reconstitution", Biophysical journal 53:2
  • McDonald, M.J., Michalski, L.A. (1987) "Haptoglobin Induces a Change in the Visible Spectrum of Human Oxyhemoglobin Beta-Chains", Federation proceedings 46:6
  • McDonald, M.J., Turci, S.M., Mrabet, N.T., Himelstein, B.P., Bunn, H. (1987) "The kinetics of assembly of normal and variant human oxyhemoglobins", J Biol Chem 262: pp. 5951-5956
  • Mrabet, N.T., Shaeffer, J.R., McDonald, M.J., Bunn, H.F. (1986) "Dissociation of dimers of human hemoglobins A and F into monomers", J Biol Chem 261: pp. 1111-1115
  • Mrabet, N.T., McDonald, M.J., Turci, S.M., Sarker, R., Szabo, A., Bunn, H.F. (1986) "Electrostatic attraction governs the dimer assembly of human hemoglobins", J Biol Chem 261: pp. 5222-5228
  • McDonald, M.J., Turci, S.M., Bleichman, M., Stinson, R.A. (1985) "Functional and subunit assembly properties of Hemoglobin Alberta", J Mol Biol 183: pp. 105-112
  • Turci, S.M., McDonald, M.J. (1985) "Isolation of normal and variant human hemoglobin subunits", J Chroma 343: pp. 168-174
  • Shaeffer, J.R., McDonald, M.J., Turci, S.M., Dinda, D.M., Bunn, H.F. (1984) "Dimer-monomer dissociation of human hemoglobin", A.J Biol Chem 259: pp. 14544-14547
  • Moo-Penn, W.F., Jue, D.L., Johnson, M.H., McDonald, M.J., Turci, S.M., Shih, T.B., Jones, R.T., Therrell, B.L., Arnone, A. (1984) "Structural and functional studies of HbA Wayne, an elongated chain variant", J Mol Biol 180: pp. 1119-1140
  • McDonald, M.J., Turci, S.M., Bunn, H.F., Brewer, G.J. (1984) "Subunit assembly of normal and variant human hemoglobins. In: The Red Cell", Progress in Clin and Biol Res. 65: pp. 3-15
  • Bunn, H.F., McDonald, M.J. (1983) "Electrostatic interactions in the assembly of hemoglobin", Nature 306: pp. 498-500
  • Turci, S.M., McDonald, M.J. (1983) "The effect of pH on the rate of dissociation of the oxygenated chain tetramer of HbA A", Biochem Biophys Res Com. 111: pp. 55-60
  • Chiou, S.H., Garrick, L.M., McDonald, M.J. (1982) "Functional properties of human adult hemoglobin specifically modified at the -amino groups of the chains with D-glucose-6-phosphate", Biochemistry 21: pp. 13-20
  • Bunn, H.F., McDonald, M.J., Shapiro, R., Ho, E. (1982) "Modification of hemoglobin structure and function by nonenzymatic glycosylation. Hemoglobin and Oxygen binding", Elsevier North Holland, New York, pp. 301-305
  • McDonald, M.J. (1981) "Assembly of human adult and sickle hemoglobins from their oxygenated subunits. Differential rates of chain tetramer dissociation", J Biol Chem 256: pp. 6487-6490
  • Shaeffer, J.R., McDonald, M.J., Bunn, H.F. (1981) "Assembly of normal and abnormal human hemoglobins", Trends in biochemical sciences 6: pp. 158-161
  • Bunn, H.F., McDonald, M.J., Shapiro, A., Cole, A., Brewer, G.J., Hanash, S.M. (1981) "Chromatographic analysis of glycosylated hemoglobin. Advances in Hemoglobin Analysis", Progress in Clin and Biol Res. 60: pp. 83-94
  • McDonald, M.J., Turci, S.M., Bunn, H.F., Garrick, L.M., Brewer, G.J. (1981) "Hemoglobin structural and functional studies of genetically selected high and low level DPG rat strains. The Red Cell", Progress in Clin and Biol Res. 55: pp. 215-222
  • McDonald, M.J., Shaeffer, J.R., Turci, S.M., Bunn, H.F., Brewer, G.J. (1981) "Subunit assembly of hemoglobin A and S. In: The Red Cell", Progress in Clin and Biol Res. 55: pp. 27-36
  • McDonald, M.J., Lund, D., Bleichman, M., Bunn, H.F., DeYoung, A., Noble, R.W., Foster, B., Arnone, A. (1980) "Equilibrium, kinetic and structural properties of hemoglobin Cranston, a human variant with an elongated chain", J Mol Biol 140: pp. 353-375
  • Bunn, H.F., McDonald, M.J., Shapiro, R., Srivastave, S.K. (1980) "Non-enzymatic glycosylation of hemoglobin and proteins of the erythrocyte membrane. In: Red Blood Cells and Lens Metabolism", Elsevier North Holland, Inc., New York, pp. 455-462
  • Garrick, L.M., McDonald, M.J., Shapiro, R., Bleichman, M., McManus, M., Bunn, H.F. (1980) "Structural analysis of the minor human hemoglobin components: HbA 1a1, HbA 1a2 and HbA 1b", Eur J Biochem 106: pp. 353-359
  • Solway, J., McDonald, M.J., Bunn, H.F., Aun, F., Cole, R., Soeldner, S. (1979) "Biosynthesis of glycosylated hemoglobins in the monkey", J Lab Clin Med 93: pp. 962-972
  • McDonald, M.J., Bleichman, M., Bunn, H.F., Noble, R.W. (1979) "Functional properties of the glycosylated minor components of human adult hemoglobin", J Biol Chem 254: pp. 702-707
  • Shapiro, R., McManus, M., Garrick, L., McDonald, M.J., Bunn, H.F. (1979) "Non-enzymatic glycosylation of human hemoglobin at multiple sites", Metabolism 28: pp. 427-430
  • Bunn, H.F., Shapiro, R., McManus, M., Garrick, L., McDonald, M.J., Gallop, P.M., Gabbay, K.H. (1979) "Structural heterogeneity of human hemoglobin A due to non-enzymatic glycosylation", Journal of Biological Chemistry 254: pp. 3892-3898
  • Shaeffer, J.R., Kingston, R.E., McDonald, M.J., Bunn, H.F. (1978) "Competition of normal hemoglobin chains and sickle chains for chains as a post-translational control mechanism", Nature 276: pp. 631-633
  • McDonald, M.J., Shapiro, R., Bleichman, M., Solway, J., Bunn, H.F. (1978) "Glycosylated minor components of human adult hemoglobin. Purification, identification and partial structural analysis", J Biol Chem 253: pp. 2327-2332
  • Bunn, H.F., McDonald, M.J., Caughey, W.S. (1978) "Glycosylation of human hemoglobin. In: Biochemical and Clinical Aspects of Hemoglobin Abnormalities", Academic Press, New York, pp. 215-226
  • McDonald, M.J., Tan-Wilson, A.L., Kosman, D.J., DeYoung, A., Noble, R.W. (1977) "Ligand induced conformational changes in spin label modified human hemoglobins and chains and their carboxypeptidase A-digested derivatives. Biochem Biophys Acta", Biochem Biophys Acta. 490: pp. 51-61
  • Bunn, H.F., Shapiro, R., McDonald, M.J., Haney, D.N. (1977) The interaction of glucose with hemoglobin. In: Molecular Interaction of Hemoglobin pp. 299-308
  • McDonald, M.J., Noble, R.W., Sharma, V.S., Ranney, H.M., Crookston, J.H., Schwartz, J.M. (1975) "A comparison of the functional properties of two lepore hemoglobins with those of hemoglobin", A.J Mol Biol 94: pp. 305-310
  • McDonald, M.J., Ranney, H.M., Noble, R.W. (1975) "Kinetics of ligand binding to ferrous heme groups of hemoglobin", M Saskatoon.J Mol Biol 91: pp. 471-475
  • Hoffman, B.M., Gibson, Q.H., Bull, C., Crepeau, R.H., Edelstein, S.J., Fisher, R.G., McDonald, M.J. (1975) "Manganese-substituted hemoglobin and myoglobin", Ann NY Acad Sci 224: pp. 174-186
  • Garrick, L.M., Sharma, V.S., McDonald, M.J., Ranney, H.M. (1975) "Rat hemoglobin heterogeneity: Two structurally distinct chains and functional behavior of selected components", The Biochemical journal 149: pp. 245-258
  • Salhany, J.M., Castillo, C.L., McDonald, M.J., Gibson, Q.H. (1975) "The magnitude of subunit inequivalence for oxygen release from hemoglobin: A reinvestigation of the oxygen-pulse experiment", Proc Nat Acad Sci 72: pp. 3998-4002
  • Knowles, F.C., McDonald, M.J., Gibson, Q. (1975) "The origin of the Adams-Schuster difference spectrum of oxyhemoglobin", Biochem Biophys Res Com 66: pp. 556-563
  • McDonald, M.J., Noble, R.W., Sharma, V.S., Ranney, H.M. (1974) "Equilibrium and kinetic studies of hemoglobin I: A functionally silent amino acid substitution at an invariant residue", J Mol Biol 89: pp. 245-248
  • McDonald, M.J., Noble, R.W. (1974) "Ligand dependent conformational changes in the isolated subunits and intact tetramers of human adult and fetal hemoglobins", J Biol Chem 249: pp. 3161-3165
  • McDonald, M.J., Noble, R.W. (1972) "The effect of pH on the rates of ligand replacement reactions of human adult and fetal hemoglobins and their subunits", J Biol Chem 247: pp. 4282-4287
  • McDonald, M.J., Bahl, D.P. (1971) "N-Acetylgalactosaminidase from Aspergillus niger. Methods in Enzymology", Complex Carbohydrates Part B 28: pp. 754-738

Selected Intellectual Property

  • Patent - Clarizia, L., Schmidt, D., Reynaud, E., McDonald, M., Wang, X."Cell culture hydrogel and pH detection system," 20090190135 United States
  • Patent - "Cell culture hydrogel and pH detection system," 61/004,560 United States
  • Patent - Clarizia, L., Mead, J., McDonald, M."Polymer-Protein Substrates for Immunosorbent Flourescence Assays," 60/874,807 United States
  • Patent - "Polymer-Protein Substrates for Immunosorbent Fluorescence Assays," 60/874,807 United States

Selected Contracts, Fellowships, Grants and Sponsored Research

  • A Plausible Model for Deoxy Hemoglobin (), - National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health
    McDonald, M. (Principal)
  • Subunit Assembly of Human Hemoglobins - Research Career Development Award (), Sponsored Research -
  • Conformational Requirements for the Polymerization of Sickle Hemoglobin (1979), Sponsored Research - The William F. Milton Fund of Harvard University
  • Conformational Requirements for the Polymerization of Sickle Hemoglobin (1979), Sponsored Research - The William F. Milton Fund of Harvard University
    McDonald, M. (Principal)
  • Nanomanufacturing of Multifunctional Sensors (2010), Contract -
    McDonald, M.J. (Principal)
  • Nanomanufacturing of Multifunctional Sensors (2007), - U.S. Army Research Office
    McDonald, M., Mead, J.
  • PI: Nanomanufacturing of Multifunctional Sensors" (2007), Grant - U.S. Army Research Office
  • Nanomanufacturing of Multifunctional Sensors (2009), -
    McDonald, M.J. (Principal)
  • Nanomanufacturing of Multifunctional Sensors (2007), Grant -
    McDonald, M.J. (Principal)
  • Cell culture hydrogel and pH detection system (2008), - UMASS CVIP
    McDonald, M. (Principal)
  • Cell culture hydrogel and pH detection system (2008), Grant - UMASS CVIP Award
  • NANI Technology Feasibility Study (2008), Grant -
    McDonald, M.J. (Principal)
  • Novel Hydrogel-Based System for Maintenance of Mammalian Cells in Culture (), - University of Massachusetts Commercial Ventures and Intellectual Property (CVIP) Technology Development Fund Award
    Schmidt, D., Reynaud, E., Reynaud, E., McDonald, M.J., Wang, X., Clarizia, L.
  • Novel Hydrogel-Based System for Maintenance of Mammalian Cells in Culture (Materials Transfer Agreement) (), -
    Schmidt, D., Wang, X., McDonald, M.J., Reynaud, E., Clarizia, L.
  • Polymer-Protein Substrates for Immunosorbent Flourescence Assays (2007), - UMASS CVIP
    McDonald, M. (Principal)
  • Polymer-Protein Substrates for Immunosorbent Fluorescence Assays (2007), Grant - UMASS CVIP Award
  • Novel Automated Nutrient Incorporation (NANI) System (), - Accelerated Technology Transfer Teams (AT³) Program, UML Nanomanufacturing Center of Excellence
    Schmidt, D., McDonald, M.J., Reynaud, E., Wang, X.
  • Intramolecular Chaperones of Human Hemoglobin Evaluated by Recominant Technology (2000), Grant - University of Massachusetts Lowell
    McDonald, M. (Co-Principal), Skare, I. (Co-Principal)
  • Intramolecular Chaperones of Human Hemoglobin Evaluated by Recombinant Technology (2000), Grant - UML Seed Grant
  • Subunit Assembly of Normal and Variant Hemoglobin (1986), Grant - National Heart, Lung and Blood Institute, National Institutes of Health
  • Subunit Assembly of Normal and Variant Hemoglobins (1986), Grant - National Heart, Lung and Blood Institute, National Institues of Health
    McDonald, M. (Principal)
  • Subunit Assembly of Human Hemoglobins (1985), Grant - National Heart, Lung and Blood Institute, National Institutes of Health
  • Subunit Assembly of Normal and Variant Hemoglobins (1985), Grant - National Heart, Lung and Blood Institute, National Institues of Health
    McDonald, M. (Principal)
  • Subunit Assembly of Human Hemoglobins (1982), Sponsored Research - National Heart, Lung and Blood Institute, National Institues of Health
    McDonald, M. (Principal)
  • Subunit Assembly of Human Hemoglobins - Research Career Development Award (1982), Sponsored Research - National Heart, Lung and Blood Institute, National Institutes of Health
  • Subunit Assembly of Human Hemoglobins (1982), Grant - National Heart, Lung and Blood Institute, National Institutes of Health
  • Subunit Assembly of Normal and Variant Hemoglobins (1982), Grant - National Heart, Lung and Blood Institute, National Institues of Health
    McDonald, M. (Principal)
  • A Plausible Model for Deoxy Hemoglobin", Research Fellowship Awards (1974), Fellowship - National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health