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Yi-Ning Wu

Yi-Ning (Winnie) Wu is an Assistant Professor in the Department of Physical Therapy at UMass Lowell.
Yi-Ning WuAssociate Professor, Scientific Lead in Physiological Measurement, NERVE Center

Research Interests

Understanding motor control/adaptation and muscle adaption due to injury and intervention, Technology-based rehabilitation for Post-concussion syndrome


  • Ph D: Institute of Biomedical Engineering, (2007), National Cheng Kung University - Tainan, Taiwan
    Dissertation/Thesis Title: Quantification of Abnormal Muscle Tone in Animal Model and in Clinical Setting.
  • BS: Department of Physical Therapy, (2000), National Cheng Kung University - Tainan, Taiwan

Selected Awards and Honors

  • 2015 Faculty Award for Teaching Excellence (2015), Teaching - University of Massachusetts Lowell
  • Sarah Baskin Award for Excellence in Research, 1st place (2010), Scholarship/Research - Rehabilitation Institute of Chicago
  • Switzer Fellowship Award (2009), Scholarship/Research - National Institute of Disability Research and Rehabilitation (NIDRR), Department of Education
  • Student Travel Scholarship (2007), Scholarship/Research - American Academy for Cerebral Palsy and Developmental Medicine
  • Li Foundation Fellow (2005), Scholarship/Research - Li Foundation
  • Podium Paper Award (2003), Scholarship/Research - Biomedical Engineerinig Society
  • Design of Associative Devices for the Disabled (2002) - TiC100

Selected Publications

  • Zheng, Y., Huang, T., Wang, T., Mei, Z., Sun, Z., Zhang, T., Ellervik, C., Chai, J.F., Sim, X., van Dam, R.M., Tai, E.S., Koh, W.P., Dorajoo, R., Saw, S.M., Sabanayagam, C., Wong, T.Y., Gupta, P., Rossing, P., Ahluwalia, T.S., Vinding, R.K., Bisgaard, H., Bønnelykke, K., Wang, Y., Graff, M., Voortman, T., van Rooij FJA, ., Hofman, A., van Heemst, D., Noordam, R., Estampador, A.C., Varga, T.V., Enzenbach, C., Scholz, M., Thiery, J., Burkhardt, R., Orho-Melander, M., Schulz, C.A., Ericson, U., Sonestedt, E., Kubo, M., Akiyama, M., Zhou, A., Kilpeläinen, T.O., Hansen, T., Kleber, M.E., Delgado, G., McCarthy, M., Lemaitre, R.N., Felix, J.F., Jaddoe VWV, ., Wu, Y., Mohlke, K.L., Lehtimäki, T., Wang, C.A., Pennell, C.E., Schunkert, H., Kessler, T., Zeng, L., Willenborg, C., Peters, A.B., Lieb, W., Grote, V., Rzehak, P., Koletzko, B., Erdmann, J., Munz, M., Wu, T., He, M., Yu, C., Lecoeur, C., Froguel, P., Corella, D., Moreno, L.A., Lai, C.Q., Pitkänen, N., Boreham, C.A., Ridker, P.M., Rosendaal, F.R., de Mutsert, R., Power, C., Paternoster, L., Sørensen TIA, ., Tjønneland, A., Overvad, K., Djousse, L., Rivadeneira, F., Lee, N.R., Raitakari, O.T., Kähönen, M., Viikari, J., Langhendries, J.P., Escribano, J., Verduci, E., Dedoussis, G., König, I., Balkau, B., Coltell, O., Dallongeville, J., Meirhaeghe, A., Amouyel, P., Gottrand, F., Pahkala, K., Niinikoski, H., Hyppönen, E., März, W., Mackey, D.A., Gruszfeld, D., Tucker, K.L., Fumeron, F., Estruch, R., Ordovas, J.M., Arnett, D.K., Mook-Kanamori, D.O., Mozaffarian, D., Psaty, B.M., North, K.E., Chasman, D.I., Qi, L. (2020). Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. European journal of epidemiology.
  • Xu, D., Wu, Y., Gaebler-Spira, D., Gao, F., Clegg, N.J., Delgado, M.R., Zhang, L.Q. (2020). Neural and non-neural contributions to ankle spasticity in children with cerebral palsy. Developmental medicine and child neurology.
  • Wu, Y., Gravel, J., Chatiwala, N., Enis, T., Stark, C., Cantu, R. (2018). Effects of Electrical Stimulation in People with Post-Concussion Syndromes: A Pilot Study. Health, 10(4) 381-395.
  • Kastroba, B., Wu, Y., Kao, P.C., Stark, C., Yen, S., Roh, J. (2018). Muscle activation pattern during self-propelled treadmill walking. Journal of Physical Therapy Science, 30(8) 1069-1072.
  • Zhu, Y., Wu, Y., Su, H., Hu, S., Cao, T., Zhang, J., Cao, Y. (2017). Identify Non-fatigue State to Fatigue State Using Causality Measure During Game Play (pp. 581--588).
  • Lydakis, A., Meng, Y., Munroe, C., Wu, Y., Begum, M. (2017). A learning-based agent for home neurorehabilitation. IEEE ... International Conference on Rehabilitation Robotics : [proceedings], 2017 1233-1238.
  • Meng, Y., Munroe, C., Wu, Y., Begum, M. (2016). A learning from demonstration framework to promote home-based neuromotor rehabilitation (pp. 1126--1131).
  • Ren, Y., Wu, Y., Yang, C.Y., Xu, T., Harvey, R., Zhang, L.Q. (2016). Developing a wearable ankle rehabilitation robotic device for in-bed acute stroke rehabilitation. IEEE Trans Neural Syst Rehabil Eng.
  • Yen, S.C., Corkery, M.B., Donohoe, A., Grogan, M., Wu, Y. (2016). Feedback and Feedforward Control During Walking in Individuals With Chronic Ankle Instability. J Orthop Sports Phys Ther, 46(9) 775-83.
  • Chen, K., Wu, Y., Ren, Y., Liu, L., Gaebler-Spira, D., Tankard, K., Lee, J., Song, W., Wang, M., Zhang, L.Q. (2016). Home-based versus laboratory-based robotic ankle training for children with cerebral palsy: A pilot randomized comparative trial. Arch Phys Med Rehabil.
  • Wu, Y., Ren, Y., Tsai, L.C., Gao, F., Zhang, L.Q. (2016). In vivo simultaneous evaluations of sarcomere imaging and muscle fiber tension. J Biomech, 49(5) 797-801.
  • Wu, Y., Hallbourg, K.W., Collins, S.M. (2015). Changes of general fitness and muscle properties following police cadet training. J Phys Ther Sci, 27(9) 2783-6.
  • Wu, Y., Saliu, V., Donoghue, N., Donoghue, J., Kerman, K. (2013). A Home-based massed practice system for pediatric neurorehabilitation. Journal of Accessibility and Design for All, 3(2) 95-117.
  • Ren, Y., Kang, S.H., Park, H.S., Wu, Y., Zhang, L.Q. (2013). Developing a multi-joint upper limb exoskeleton robot for diagnosis, therapy, and outcome evaluation in neurorehabilitation. IEEE Trans Neural Syst Rehabil Eng, 21(3) 490-9.
  • Wong, K., Boulanger, L., Smalarz, A., Wu, Y., Fraser, K., Wogen, J. (2013). Impact of care management processes and integration of care on blood pressure control in diabetes. BMC Family Practice, 14(1) 30 - 39.
  • Drobyshevsky, A., Derrick, M., Luo, K., Zhang, L.Q., Wu, Y., Takada, S.H., Yu, L., Tan, S. (2012). Near-term fetal hypoxia-ischemia in rabbits: MRI can predict muscle tone abnormalities and deep brain injury. Stroke, 43(10) 2757-63.
  • Wu, Y., Wilcox, B., Donoghue, J.P., Crisco, J., Kerman, K.L. (2012). The impact of massed practice on children with hemiplegic cerebral palsy: Pilot study of home-based toy play therapy. Journal of medical and biological engineering, 32(5) 331-342.
  • Zhao, H., Wu, Y., Hwang, M., Ren, Y., Gao, F., Gaebler-Spira, D., Zhang, L.Q. (2011). Changes of calf muscle-tendon biomechanical properties induced by passive-stretching and active-movement training in children with cerebral palsy. J Appl Physiol (1985), 111(2) 435-42.
  • Wu, Y., Hwang, M., Ren, Y., Gaebler-Spira, D., Zhang, L.Q. (2011). Combined passive stretching and active movement rehabilitation of lower-limb impairments in children with cerebral palsy using a portable robot. Neurorehabil Neural Repair, 25(4) 378-85.
  • Peng, Q., Park, H.S., Shah, P., Wilson, N., Ren, Y., Wu, Y., Liu, J., Gaebler-Spira, D.J., Zhang, L.Q. (2011). Quantitative evaluations of ankle spasticity and stiffness in neurological disorders using manual spasticity evaluator. J Rehabil Res Dev, 48(4) 473-81.
  • Khan, N., Levin, S.D., Domont, Z.B., Wu, Y., Ren, Y., Zhang, L.Q. (2011). Strain effects of placing an arthroscopic portal through the subscapularis tendon. J Shoulder Elbow Surg, 20(1) 33-8.
  • Wu, Y., Ren, Y., Goldsmith, A., Gaebler, D., Liu, S.Q., Zhang, L.Q. (2010). Characterization of spasticity in cerebral palsy: dependence of catch angle on velocity. Dev Med Child Neurol, 52(6) 563-9.
  • Wu, Y., Ren, Y., Hwang, M., Gaebler-Spira, D.J., Zhang, L.Q. (2010). Efficacy of robotic rehabilitation of ankle impairments in children with cerebral palsy. Conf Proc IEEE Eng Med Biol Soc, 2010 4481-4.
  • Wu, Y., Ren, Y., Zhang, L.Q. (2010). In vivo sarcomere imaging and fiber tension measurements. Conf Proc IEEE Eng Med Biol Soc, 2010 1986-9.
  • Hsieh, T.H., Tsai, J.Y., Wu, Y., Hwang, I.S., Chen, T.I., Chen, J.J. (2010). Time course quantification of spastic hypertonia following spinal hemisection in rats. Neuroscience, 167(1) 185-98.
  • Zhao, H., Wu, Y., Liu, J., Ren, Y., Gaebler-Spira, D.J., Zhang, L.Q. (2009). Changes of calf muscle-tendon properties due to stretching and active movement of children with cerebral palsy–a pilot study. Conf Proc IEEE Eng Med Biol Soc, 2009 5287-90.
  • Wu, Y., Chen, J.J., Zhang, L.Q., Hyland, B.I. (2009). Regulation of hind-limb tone by adenosine A2A receptor in rats. Neuroscience, 159(4) 1408-13.
  • Zhao, H., Ren, Y., Wu, Y., Liu, S.Q., Zhang, L.Q. (2009). Ultrasonic evaluations of Achilles tendon mechanical properties poststroke. J Appl Physiol (1985), 106(3) 843-9.
  • Lee, H.M., Chen, J.J., Wu, Y., Wang, Y.L., Huang, S.C., Piotrkiewicz, M. (2008). Time course analysis of the effects of botulinum toxin type a on elbow spasticity based on biomechanic and electromyographic parameters. Arch Phys Med Rehabil, 89(4) 692-9.
  • Ren, Y., Park, H., Wu, Y., Geiger, F., Zhang, L.Q. (2008). Training for knee injury prevention using a pivoting elliptical machine. Conf Proc IEEE Eng Med Biol Soc, 2008 727-30.
  • Wu, Y., Hyland, B.I., Chen, J.J. (2007). Biomechanical and electromyogram characterization of neuroleptic-induced rigidity in the rat. Neuroscience, 147(1) 183-96.
  • Wu, Y., Park, H.S., Ren, Y., Gaebler-Spira, D., Chen, J.J., Zhang, L.Q. (2006). Measurement of elbow spasticity in stroke patients using a manual spasticity evaluator. Conf Proc IEEE Eng Med Biol Soc, 1 3974-7.
  • Chen, J.J., Wu, Y., Huang, S.C., Lee, H.M., Wang, Y.L. (2005). The use of a portable muscle tone measurement device to measure the effects of botulinum toxin type a on elbow flexor spasticity. Arch Phys Med Rehabil, 86(8) 1655-60.
  • Lin, S.I., Tsai, T.T., Lee, I.H., Wu, Y. (2002). Perception of unsteadiness in patients with dizziness: association with handicap and imbalance. J Biomed Sci, 9(5) 428-35.

Selected Intellectual Property

  • Patent - Zhang, L., Wu, Y., Ren, Y."System and Method of Microscopic Imaging and Soft Tissue Tension Measurements," 7998094 United States

Selected Contracts, Fellowships, Grants and Sponsored Research

  • The effects of the cervical electrical stimulation and aerobic exercise on people with post-concussion syndrome (2016), Sponsored Research - Emerson Hospital
    Wu, Y.
  • Method and technology assessment literature review (2014), Contract - Biogen Idec
    Wu, Y.
  • Pilot multi-center evaluations of reflex and nonreflex changes in cerebral palsy (2013), Contract -
    Wu, Y. (Principal)