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Jinxiang Xi


Image of Jinxiang Xi
Dr. Jinxiang XiAssociate Professor

Research Interests

Respiratory dynamics, inhalation toxicology, aerosol-based tumor diagnosis, personalized drug delivery, snoring and apnea.

  • Multi-scale modeling of respiratory flows and aerosol dynamics
  • Inhalation medical device design, testing, and optimization
  • Aerosol-based tumor diagnosis and targeted inhalation drug delivery
  • Fluid-structure interactions, multi-phase flows, vortex dominated flows
  • Computational and Experiment fluid mechanics, statistical shape modeling
  • Statistical and probabilistic analysis in inhalation therapy
  • Machine learning and data mining in engineering applications

Education

  • Ph D: Mechanical Engineering, (2005), Texas A&M University - College Station
    Supporting Area: Turbomachinery Rotordynamics
    Dissertation/Thesis Title: Improved Seal-inlet Disturbance Boundary Conditions for CFD-Perturbation Rotordynamic Seal Models and a New Curvature Law of the Wall
  • MS: Mechanical Engineering, (1999), Xi’an JiaoTong University - Xi'an, Shaanxi, China
    Supporting Area: Combustion and thermal sciences
    Dissertation/Thesis Title: Experimental and Numerical Study on Separating Mechanism of Cyclone Separator with Downward Exhaust Gas
  • BS: Mechanical Engineering, (1996), Shanghai JiaoTong University - Shanghai, China
    Supporting Area: Combustion and thermal sciences
    Dissertation/Thesis Title: Numerical Study on atomizing mechanism and Internal Flow of Y-shaped atomizer

Biography

Dr. Jinxiang Xi is an Associate Professor of Biomedical Engineering at UMass Lowell. He obtained his Ph.D. in Mechanical Engineering from Texas A&M University in 2005. Before joining UML, he has worked as an Assistant Professor at the University of Arkansas, Little Rock and Central Michigan University, and an Associate Professor at California Baptist University.

Dr Xi. has sixteen years’ research experience in biomedical devices and pharmaceutical research. His research in respiratory aerosol dynamics is highly interdisciplinary, which bridges biology, medicine, and engineering. Applications include inhalation toxicology, aerosol-based tumor diagnosis, and personalized drug delivery. Dr. Xi won the 2012 Monaghan-Trudell Award from American Respiratory Care Foundation for his contributions to “Aerosol Technology Development”.

Selected Awards and Honors

  • Monaghan/Trudell Award (2012), Scholarship/Research - American Respiratory Care Foundation

Selected Publications

  • Xi, J., Zhao, W. (). Correlating exhaled aerosol images to small airway obstructive diseases: A study with dynamic mode decomposition and machine learning. PLOS ONE, 14(1) e0211413.
  • Xi, J., Zhao, W., Yuan, J.E., Kim, J., Si, X., Xu, X. (). Detecting Lung Diseases from Exhaled Aerosols: Non-Invasive Lung Diagnosis Using Fractal Analysis and SVM Classification. PLOS ONE, 10(9) e0139511.
  • Xi, J., Si, X.A., Gaide, R. (). Electrophoretic Particle Guidance Significantly Enhances Olfactory Drug Delivery: A Feasibility Study. PLoS ONE, 9(1) e86593.
  • Xi, J., Si, X., Longest, W. (). Electrostatic Charge Effects on Pharmaceutical Aerosol Deposition in Human Nasal–Laryngeal Airways. Pharmaceutics, 6(1) 26-35.
  • Xi, J., Si, X.A., Kim, J., Mckee, E., Lin, E. (). Exhaled Aerosol Pattern Discloses Lung Structural Abnormality: A Sensitivity Study Using Computational Modeling and Fractal Analysis. PLoS ONE, 9(8) e104682.
  • Xi, J., Zhang, Z., Si, X. (). Improving intranasal delivery of neurological nanomedicine to the olfactory region using magnetophoretic guidance of microsphere carriers. International Journal of Nanomedicine, 1211.
  • Si, X.A., Xi, J. (). Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols. Journal of Visualized Experiments, (111).
  • Xi, J., Hu, Q., Zhao, L., Si, X. (). Molecular Binding Contributes to Concentration Dependent Acrolein Deposition in Rat Upper Airways: CFD and Molecular Dynamics Analyses. International Journal of Molecular Sciences, 19(4) 997.
  • Xi, J., Talaat, M. (). Nanoparticle Deposition in Rhythmically Moving Acinar Models with Interalveolar Septal Apertures. Nanomaterials, 9(8) 1126.
  • Xi, J., Yuan, J., Si, X., Hasbany, J. (). Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis. International Journal of Nanomedicine, 4847.
  • Xi, J., Si, X.A. (). Numerical Simulation and Experimental Testing to Improve Olfactory Drug Delivery with Electric Field Guidance of Charged Particles. InTech
  • Xi, J. (). Review of Feature Extraction from Exhaled Aerosol Fingerprints to Diagnose Lung Structural Remolding. Biomedical Journal of Scientific & Technical Research, 11(3).
  • Xi, J., Kim, J., A., X. (). Ultrafine and Fine Aerosol Deposition in the Nasal Airways of a 9-Month-Old Girl, a 5-Year-Old Boy and a 53-Year-Old Male. InTech
  • Wells, B., Guest, N., Martinez, J., Hakizimana, E., April Si, X., Su, W., Xi, J. (). Visualization and quantification of nebulized aerosol deposition in mouth-lung casts under healthy and abnormal breathing conditions. Lungs and Breathing, 2(2).
  • Xi, J., Yang, T. (2019). Variability in oropharyngeal airflow and aerosol deposition due to changing tongue positions. Journal of Drug Delivery Science and Technology, 49 674-682.
  • Su, W., Chen, Y., Xi, J. (2019). A new approach to estimate ultrafine particle respiratory deposition. Inhalation Toxicology, 31(1) 35-43.
  • Xi, J., Talaat, K., Si, X.A. (2018). Deposition of bolus and continuously inhaled aerosols in rhythmically moving terminal alveoli. The Journal of Computational Multiphase Flows, 10(4) 178-193.
  • Xi, J., April Si, X., Dong, H., Zhong, H. (2018). Effects of glottis motion on airflow and energy expenditure in a human upper airway model. European Journal of Mechanics - B/Fluids, 72 23-37.
  • Xi, J., Talaat, M., Tanbour, H., Talaat, K. (2018). Airflow and Particle Deposition in Acinar Models with Interalveolar Septal Walls and Different Alveolar Numbers. Computational and Mathematical Methods in Medicine, 2018 1-18.
  • Wang, J., Han, P., Sanchez, Y., Xi, J., Dong, H. (2018). Computational Analysis on Aerodynamics and Vortex Formation of Sleep Apnea. American Society of Mechanical Engineers
  • Xi, J., Wang, Z., Si, X.A., Zhou, Y. (2018). Nasal dilation effects on olfactory deposition in unilateral and bi-directional deliveries: In vitro tests and numerical modeling. European Journal of Pharmaceutical Sciences, 118 113-123.
  • Xi, J., Wang, Z., Talaat, K., Glide-Hurst, C., Dong, H. (2018). Numerical study of dynamic glottis and tidal breathing on respiratory sounds in a human upper airway model. Sleep and Breathing, 22(2) 463-479.
  • Xi, J., Yang, T., Talaat, K., Wen, T., Zhang, Y., Klozik, S., Peters, S. (2018). Visualization of local deposition of nebulized aerosols in a human upper respiratory tract model. Journal of Visualization, 21(2) 225-237.
  • Lu, J., Xi, J., Langenderfer, J.E. (2017). Sensitivity Analysis and Uncertainty Quantification in Pulmonary Drug Delivery of Orally Inhaled Pharmaceuticals. Journal of Pharmaceutical Sciences, 106(11) 3303-3315.
  • Talaat, K., Xi, J. (2017). Computational modeling of aerosol transport, dispersion, and deposition in rhythmically expanding and contracting terminal alveoli. Journal of Aerosol Science, 112 19-33.
  • Xi, J., Zhao, W., Yuan, J.E., Cao, B., Zhao, L. (2017). Multi-resolution classification of exhaled aerosol images to detect obstructive lung diseases in small airways. Computers in Biology and Medicine, 87 57-69.
  • Xi, J., Wang, Z., Nevorski, D., White, T., Zhou, Y. (2017). Nasal and Olfactory Deposition with Normal and Bidirectional Intranasal Delivery Techniques: In Vitro Tests and Numerical Simulations. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(2) 118-131.
  • Xi, J., Si, X.A., Peters, S., Nevorski, D., Wen, T., Lehman, M. (2017). Understanding the mechanisms underlying pulsating aerosol delivery to the maxillary sinus: In vitro tests and computational simulations. International Journal of Pharmaceutics, 520(1-2) 254-266.
  • Xi, J., Kim, J., Si, X.A., Corley, R.A., Zhou, Y. (2016). Modeling of inertial deposition in scaled models of rat and human nasal airways: Towards in vitro regional dosimetry in small animals. Journal of Aerosol Science, 99 78-93.
  • Xi, J., Yuan, J.E., Yang, M., Si, X., Zhou, Y., Cheng, Y. (2016). Parametric study on mouth–throat geometrical factors on deposition of orally inhaled aerosols. Journal of Aerosol Science, 99 94-106.
  • Xi, J., Zhang, Z., Si, X.A., Yang, J., Deng, W. (2016). Optimization of magnetophoretic-guided drug delivery to the olfactory region in a human nose model. Biomechanics and Modeling in Mechanobiology, 15(4) 877-891.
  • Xi, J., Yuan, J.E., Zhang, Y., Nevorski, D., Wang, Z., Zhou, Y. (2016). Visualization and Quantification of Nasal and Olfactory Deposition in a Sectional Adult Nasal Airway Cast. Pharmaceutical Research, 33(6) 1527-1541.
  • Xi, J., Yuan, J.E., Si, X.A. (2016). Simulation study of electric-guided delivery of 0.4µm monodisperse and polydisperse aerosols to the ostiomeatal complex. Computers in Biology and Medicine, 72 1-12.
  • Xi, J., Kim, J., Si, X.A. (2016). Effects of nostril orientation on airflow dynamics, heat exchange, and particle depositions in human noses. European Journal of Mechanics - B/Fluids, 55 215-228.
  • Xi, J., Kim, J., Si, X.A., Corley, R.A., Kabilan, S., Wang, S. (2015). CFD Modeling and Image Analysis of Exhaled Aerosols due to a Growing Bronchial Tumor: towards Non-Invasive Diagnosis and Treatment of Respiratory Obstructive Diseases. Theranostics, 5(5) 443-455.
  • Xi, J., Si, X.A., Kim, J.W. (2015). Characterizing Respiratory Airflow and Aerosol Condensational Growth in Children and Adults Using an Imaging-CFD Approach (pp. 125-155). Elsevier
  • Xi, J., Kim, J., Si, X.A., Su, W.C., Zhou, Y. (2014). Effects of the facial interface on inhalation and deposition of micrometer particles in calm air in a child airway model. Inhalation Toxicology, 26(8) 492-505.
  • Xi, J., Si, X., Kim, J., Su, G., Dong, H. (2014). Modeling the pharyngeal anatomical effects on breathing resistance and aerodynamically generated sound. Medical & Biological Engineering & Computing, 52(7) 567-577.
  • Kim, J., Xi, J., Si, X., Berlinski, A., Su, W.C. (2014). Hood Nebulization: Effects of Head Direction and Breathing Mode on Particle Inhalability and Deposition in a 7-Month-Old Infant Model. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(3) 209-218.
  • Zhou, Y., Guo, M., Xi, J., Irshad, H., Cheng, Y. (2014). Nasal Deposition in Infants and Children. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2) 110-116.
  • Si, X., Xi, J., Kim, J. (2013). Effect of Laryngopharyngeal Anatomy on Expiratory Airflow and Submicrometer Particle Deposition in Human Extrathoracic Airways. Open Journal of Fluid Dynamics, 03(04) 286-301.
  • Xi, J., Kim, J., Si, X.A., Zhou, Y. (2013). Hygroscopic aerosol deposition in the human upper respiratory tract under various thermo-humidity conditions. Journal of Environmental Science and Health, Part A, 48(14) 1790-1805.
  • Xi, J., Kim, J., Si, X.A., Zhou, Y. (2013). Diagnosing obstructive respiratory diseases using exhaled aerosol fingerprints: A feasibility study. Journal of Aerosol Science, 64 24-36.
  • Si, X.A., Xi, J., Kim, J., Zhou, Y., Zhong, H. (2013). Modeling of release position and ventilation effects on olfactory aerosol drug delivery. Respiratory Physiology & Neurobiology, 186(1) 22-32.
  • Zhou, Y., Xi, J., Simpson, J., Irshad, H., Cheng, Y. (2013). Aerosol Deposition in a Nasopharyngolaryngeal Replica of a 5-Year-Old Child. Aerosol Science and Technology, 47(3) 275-282.
  • Kim, J.W., Xi, J., Si, X.A. (2013). Dynamic growth and deposition of hygroscopic aerosols in the nasal airway of a 5-year-old child. International Journal for Numerical Methods in Biomedical Engineering, 29(1) 17-39.
  • Xi, J., Berlinski, A., Zhou, Y., Greenberg, B., Ou, X. (2012). Breathing Resistance and Ultrafine Particle Deposition in Nasal–Laryngeal Airways of a Newborn, an Infant, a Child, and an Adult. Annals of Biomedical Engineering, 40(12) 2579-2595.
  • Xi, J., Si, X., Kim, J.W., Berlinski, A. (2011). Simulation of airflow and aerosol deposition in the nasal cavity of a 5-year-old child. Journal of Aerosol Science, 42(3) 156-173.
  • Si, X., Xi, J., Tao, X. (2010). The Study of Calcium Carbonate Scaling on Low Energy Surfaces. ASME
  • Longest, P.W., Xi, J. (2010). 11 Evaluation of continuous and discrete phase models for simulating submicrometer aerosol transport and deposition (pp. 425-457). WIT Press
  • Xi, J., Longest, P., Anderson, P. (2010). Respiratory Aerosol Dynamics with Applications to Pharmaceutical Drug Delivery (pp. 501-526). CRC Press
  • Si, X., Youn, S., Xi, J. (2009). Reducing Scale Deposition by Surface Modification and Magnetic Water Treatment. ASME
  • Xi, J., Longest, P.W. (2009). Characterization of Submicrometer Aerosol Deposition in Extrathoracic Airways during Nasal Exhalation. Aerosol Science and Technology, 43(8) 808-827.
  • Xi, J., Longest, P.W. (2008). Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach. International Journal of Heat and Mass Transfer, 51(23-24) 5562-5577.
  • Xi, J., Longest, P.W. (2008). Evaluation of a Drift Flux Model for Simulating Submicrometer Aerosol Dynamics in Human Upper Tracheobronchial Airways. Annals of Biomedical Engineering, 36(10) 1714-1734.
  • Longest, P.W., Hindle, M., Das Choudhuri, S., Xi, J. (2008). Comparison of ambient and spray aerosol deposition in a standard induction port and more realistic mouth–throat geometry. Journal of Aerosol Science, 39(7) 572-591.
  • Xi, J., Longest, P.W., Martonen, T.B. (2008). Effects of the laryngeal jet on nano- and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. Journal of Applied Physiology, 104(6) 1761-1777.
  • Worth Longest, P., Xi, J. (2008). Condensational Growth May Contribute to the Enhanced Deposition of Cigarette Smoke Particles in the Upper Respiratory Tract. Aerosol Science and Technology, 42(8) 579-602.
  • Xi, J., Longest, P.W. (2008). Effects of Oral Airway Geometry Characteristics on the Diffusional Deposition of Inhaled Nanoparticles. Journal of Biomechanical Engineering, 130(1).
  • Xi, J., Longest, P.W. (2007). Effects of Improved Near-Wall Modeling on Micro-Particle Deposition in Oral Airway Geometries. American Society of Mechanical Engineers
  • Longest, P.W., Xi, J. (2007). Effectiveness of Direct Lagrangian Tracking Models for Simulating Nanoparticle Deposition in the Upper Airways. Aerosol Science and Technology, 41(4) 380-397.
  • Xi, J., Longest, P.W. (2007). Transport and Deposition of Micro-Aerosols in Realistic and Simplified Models of the Oral Airway. Annals of Biomedical Engineering, 35(4) 560-581.
  • Longest, P.W., Xi, J. (2007). Computational investigation of particle inertia effects on submicron aerosol deposition in the respiratory tract. Journal of Aerosol Science, 38(1) 111-130.
  • Xi, J., RHODE, D.L. (2006). Seal-Inlet Disturbance Boundary Condition Correlations for Rotordynamics Models, Part 1: Correlation Development. Tribology Transactions, 49(4) 574-583.
  • Xi, J., RHODE, D.L. (2006). Seal-Inlet Disturbance Boundary Condition Correlations for Rotordynamics Models, Part 2: Assessment. Tribology Transactions, 49(4) 584-591.
  • Xi, J., Rhode, D.L. (2006). Rotordynamics of Turbine Labyrinth Seals with Rotor Axial Shifting. International Journal of Rotating Machinery, 2006 1-11.
  • Xi, J., RHODE, D.L. (2006). Rotordynamics of Impeller Eye Seals with Wear-Damaged Teeth in Centrifugal Compressors. Tribology Transactions, 49(3) 328-337.
  • Xi, J., Si, X., Longest, P.W., Gad-el-Hak, M. (2006). Curvature Law of the Wall for Swirling Axial Flows in Rotating Machinery. Journal of Fluids Engineering, 129(2) 169-178.
  • Xi, J. (2005). Curvature Law of the Wall for Swirling Axial Flows. ASME
  • Xi, J., Rhode, D.L. (2005). Influence of Rotor Axial Thermal Growth on Rotordynamic Forces of High-Low Labyrinth Seals in Steam Turbines. ASME
  • Xi, J., Rhode, D.L. (2005). Influence of Teeth Damage on Rotordynamic Instability of Impeller Eye Seals in Centrifugal Compressors. ASME