Guixin (Susan) He is an Associate Professor in the Biomedical & Nutritional Sciences dept. at UMass Lowell.

Gui-Xin (Susan) He, Ph.D.

Associate Professor

Zuckerberg College of Health Sciences
Biomedical & Nutritional Sciences
(978) 934-4363
Weed Hall - Weed 314



Research Interests

Molecular Microbiology, Genetics, Antibiotic Resistance

I have been working on the antibiotic resistance mechanism and the cell membrane transporter in Pseudomonas aeruginosa and Enterobacter cloacae for more than 10 years. Currently we are focusing on the following studies: 1) Investigating the biofilm and drug resistance development; 2) Analyzing resistance genes in antibiotic resistant Enteric bacteria; 3) Developing biosensors for drug resistance and pathogens


  • Ph D: Microbiology, (2004), Okayama University - Okayama, Japan
  • MS: Biochemistry, (2001), Okayama University - Okayama, Japan
  • BS: Bioenergy, (1994), Shenyang Agricultural University - Shenyang, P. R.China

Selected Awards and Honors

  • Government Scholarship - Ministry of Education, Japan
  • Postdoctoral Fellowship - NIH-IDeA Networks of Biomedical Research Excellence
  • Outstanding Service Award (2010), Service, Professional - American Society for Microbiology (ASM)
  • Travel Award (2009) - ASM (The Annual Biomedical Research Conference for Minority Students)

Selected Publications

  • Sun, J., Kweon, O., Jin, J., He, G., Li, X., Gerniglia, C., Chen, H. (2017). Mutation network-based understanding of pleiotropic and epistatic mutational behavior ofEnterococcus faecalis FMN-dependent azoreductase (12: pp. 240-244). Biochemistry and Biophysics Reports
  • Mukherjee, M., Kumar, S., Shrestha, U., Ranaweera, I., KC, R., Prathuska Kakarla, T., Willmon, M., Hernandez, A.J., He, G., Lau, C., Barr, S.R., Varela, M.F. (2016). Comparative genomics and discovery of novel cellular targets for the development of new therapeutics towards Vibrio cholerae, the causative agent of cholera disease. 14 1-12.
  • Kumar, S., He, G., Kakarla, P., Shrestha, U., KC, R., Ranaweera, I.T., Willmon, M., Barr, S.R., Hernandez, A.J. (2016). Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation.
  • Pan, H., Xu, J., Kweon, O., Zou, W., Feng, J., He, G., Cerniglia, C.E., Chen, H. (2015). Differential gene expression in Staphylococcus aureus exposed to Orange II and Sudan III azo dyes. Journal of Industrial Microbiology and Biotechnology, (5) 745.
  • Andersen, J.L., He, G., Kakarla, P., Ranjana, K.C., Kumar, S., Lakra, W.S., Mukherjee, M.M., Ranaweera, I., Shrestha, U., Tran, T., Varela, M.F. (2015). Multidrug efflux pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus bacterial food pathogens. International Journal Of Environmental Research And Public Health, 12(2) 1487-1547.
  • Pan, H., Zhang, Y., He, G., Katagori, N., Chen, H. (2014). A comparison of conventional methods for the quantification of bacterial cells after exposure to metal oxide nanoparticles. BMC Microbiology, 14(1).
  • Mukherjee, M., He, G., Katagori, N., Chen, H. (2014). Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1 Vibrio cholera . Genomics Discovery, 2(1) 1-15.
  • He, G., Landry, M., Chen, H., Thorpe, C., Walsh, D., Varela, M.F., Pan, H. (2014). Detection of benzalkonium chloride resistance in community environmental isolates of staphylococci. Journal of medical microbiology, 63 735-741.
  • Varela, M., Kumar, S., He, G. (2013). Potential for inhibition of bacterial efflux pumps in multidrug-resistant Vibrio cholerae. Indian Journal of Medical Research, 138(SEP) 285-287.
  • Pan, H., Feng, J., He, G., Cerniglia, C.E., Chen, H. (2012). Evaluation of impact of exposure of Sudan azo dyes and their metabolites on human intestinal bacteria. Anaerobe, 18(4) 445-453.
  • He, G., Thorpe, C., Walsh, D., Crow, R., Chen, H., Kumar, S., Varela, M.F. (2011). EmmdR, a new member of the MATE family of multidrug transporters, extrudes quinolones from Enterobacter cloacae. Archives of Microbiology, 193(10) 759-765.
  • He, G., Zhang, C., Crow, R.R., Thorpe, C., Chen, H., Kumar, S., Tsuchiya, T., Varela, M.F. (2011). SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae. Antimicrobial Agents and Chemotherapy, 55(8) 3954-3957.

Selected Contracts, Fellowships, Grants and Sponsored Research

  • Government Scholarship (2001), Fellowship - Ministry of Education, Japan