Expertise
Synthetic chemistry, Pathogen glycobiology, Assay development, Interdisciplinary research, Biosensors
Research Interests
Synthetic chemistry, Pathogen glycobiology, Assay development, Interdisciplinary research, Biosensors
Education
- B.S.: Chemistry (Honors), Fergusson College, Pune, India. 1990.
- M.S.: Organic Chemistry (Honors), Indian Institute of Technology, Bombay, India. 1992.
- Ph.D.: Chemistry, Indiana University, Bloomington, Indiana, USA. 2000.
Biosketch
Research in my group has focused on the synthesis and development of glycans for infectious agents for the past 19 years since 2004. I have a diverse experience in several areas of Chemistry and biosensor development. I worked under the guidance of Malcolm Chisholm, (Indiana University, organometallic and polymer Chemistries, Ph.D.), Dr. Elliot Chaikof, a surgeon, anticoagulant biomaterials, Emory School of Medicine), Basil Swanson (Los Alamos National Laboratory, analytical chemist, biosensors). At UC and GSU, I worked on the development of tailored carbohydrates to detect and differentiate between select toxins and pathogens. At UML, I lead a group of talented scientists from various disciplines, chemists, virologists and biosensor developers working towards the goal of developing diagnostics for a variety of infectious agents and human disorders.
Selected Publications
- Liu, D., Merlin, D. and Iyer, S.S. Inflammatory Bowel Disease Biomarkers, submitted to Medicinal Research Reviews, Inflammatory bowel disease biomarkers, Medicinal Research Reviews 42 (5), 1856- 1887
- Iyer S.S. and Kumar, M., ASSURED-SQVM Diagnostics for COVID-19: Addressing the Why, When, Where, Who, What and How of Testing, review article, Expert Review of Molecular Diagnostics, 2021,4,349-362.
- Sheng, X., Liu, D., Gamage, S. K., Luo, Y., Viennois, E., Merlin, D. and Iyer, S.S. Point-of-Care Monitoring of Colitis using Intestinal Alkaline Phosphatase in Inflammatory Bowel Disease, submitted to ACS Sensors, 2021, 6, 698-702. doi: 10.1021/acssensors.0c02177
- Luo, Y., Jia, Fang, J., Liu, D., Saikam, V., Sheng, X., and Iyer, S.S. Rapid, user-friendly and inexpensive detection of Azidothymidine, Analytical and Bioanalytical Chemistry, 2021, 413, 1999-2006. doi: 10.1007/s00216-021-03168-z.
Selected Intellectual Property
- Electrochemical methods and compounds for the detection of enzymes Patent number: 10408783.
Abstract: Disclosed are compositions and methods for the electrochemical detection of enzymes, such as enzymes that are indicative of disease, disorders, or pathogens, such as viruses, bacteria, and fungi, or other disorders. These methods can be used in point-of-care diagnostic assays for the detection of disease, disorder, or pathogen (e.g., to identify the strain of pathogen infecting a patient in a healthcare setting). The electrochemical methods described herein can also be used to assess the susceptibility of a pathogen to an antipathogen drug. Also provided are probes suitable for use in conjunction with the methods described herein. Filed: June 1, 2015 Granted Date of Patent: September 10, 2019 Assignee: Georgia State University research foundation, inc. Inventors: Suri Saranathan Iyer, Abasaheb Dhawane, Yun He, Xiaohu Zhang, Hieu Dinh, Mugdha Vasireddi, Joyce Sweeney - Synthetic ligands for the differentiation of closely related toxins and pathogens, Patent number: 9045516.
Abstract: Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1 and Shiga toxin 2. Assay systems and methods for providing an assay are also provided for herein. Assignee: University of Cincinnati. Filed: April 16, 2008, granted Date of Patent: June 2, 2015 Inventors: Suri Saranathan Iyer, Duane Michael Hatch, Ramesh Ratan Kale, Alison Ann Weiss, Shantini Dodampe Gamage, Colleen M. McGannon.
Selected Contracts, Fellowships, Grants and Sponsored Research
- NSF Career Award, NIH RO1, NSF-REU, NIH R21/R33, NIH R61/R33