Drug delivery, Nanomedicine, Biomaterials, Immunotherapy, Gene therapy, Nanotechnology, Biomedical Engineering
My research focus is at the interface of biomedical engineering, pharmaceutical sciences, nanoparticle engineering, material science, immunology, and microbiology. I am particularly interestedin designing new drug delivery systems to deliver biomacromolecules such as proteins and nucleic acids that modulate immune functions to fight cancer, autoimmune, and infectious/inflammatory diseases.
- Joint Ph.D. program, Purdue University, USA
- Ph.D.: Pharmaceutical Sciences, China Pharmaceutical University, China
- M.S.: Pharmaceutics, China Pharmaceutical University, China
- B.S.: Pharmaceutical Engineering, Shandong University of Traditional Chinese Medicine, China
Fanfei Meng is an Assistant Professor in the Department of Biomedical and Nutritional Sciences at the University of Massachusetts, Lowell, USA. He received his BS degree in Pharmaceutical Engineering and MS degree in Pharmaceutics at China Pharmaceutical University (CPU). He started his Ph.D. in Pharmaceutical Sciences at CPU, and he finished his Ph.D. thesis research at Purdue University. His research at Purdue focuses on surface engineering various drug delivery systems for combination drug delivery, as well as investigating the limitations of fluorescence-based whole-body imaging to evaluate the in vivo biodistribution of nanomedicine. For his postdoc training at Purdue, he applied his background in nanomedicine and drug delivery to explore the application of drug formulations in cancer immunotherapy. He is interested in designing new drug delivery systems to deliver biomacromolecules such as proteins and nucleic acids that modulate immune functions to fight cancer, autoimmune, and infectious/inflammatory diseases.
- Meng, F., Wang, J, He, Y., Creswell, G.M., Lanman, N.A., Lyle, L.T., Ratliff, T.L., Yeo, Y., 2022. A single local delivery of paclitaxel and nucleic acids via an immunoactive polymer eliminates solid tumors and induces systemic antitumor immunity. Proceedings of the National Academy of Sciences, 119(22), p.e2122595119.
- Meng, F., Wang, J., and Yeo, Y., 2022. Nucleic acid and oligonucleotide delivery for activating innate immunity in cancer immunotherapy. Journal of Controlled Release, 345, 586-600.
- Wang, J.*, Meng, F.*, Kim, B.K., Ke, X. and Yeo, Y., 2019. In-vitro and in-vivo difference in gene delivery by lithocholic acid-polyethyleneimine conjugate. Biomaterials, 119296. (* co-first author)
- Meng, F., Wang, J., Ping, Q. and Yeo, Y., 2019. Camouflaging nanoparticles for ratiometric delivery of therapeutic combinations. Nano Letters, 19(3), 1479-1487. (Featured in Purdue College of Pharmacy website)
- Meng, F., Wang, J., Ping, Q. and Yeo, Y., 2018. Quantitative assessment of nanoparticle biodistribution by fluorescence imaging, revisited. ACS Nano, 12(7), 6458-6468.
- Meng, F*., Han, N*., and Yeo, Y., 2017. Organic nanoparticle systems for spatiotemporal control of multimodal chemotherapy. Expert Opinion on Drug Delivery, 14(3), 427-446. (* co-first author)
- Meng, F., Asghar, S., Xu, Y., Wang, J., Jin, X., Wang, Z., Wang, J., Ping, Q., Zhou, J. and Xiao, Y., 2016. Design and evaluation of lipoprotein resembling curcumin-encapsulated protein-free nanostructured lipid carrier for brain targeting. International Journal of Pharmaceutics, 506(1-2), 46-56.
- Meng, F., Asghar, S., Gao, S., Su, Z., Song, J., Huo, M., Meng, W., Ping, Q. and Xiao, Y., 2015. A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease. Colloids and Surfaces B: Biointerfaces, 134, 88-97.
- Torres J, Meng F, Bhattacharya S, Buno K, Ahmadzadegan A, Madduri S, Babiak P, Vlachos P, Solorio L, Yeo Y, Liu J. Interpenetrating Networks of Collagen and Hyaluronic Acid that Serve as In Vitro Tissue Models for Assessing Macromolecular Transport. Biomacromolecules. In press.
- Pei, Y, Wang, J, Khaliq, N, Meng, F., Oucherif, K.A, Xue, J, Sarena D. Horava, S.D, Cox, A.L, Richard, C.A, Swinney, M. R, Park, K, Yeo, Y., 2023. Development of poly(lactic-co-glycolic acid) microparticles for sustained delivery of meloxicam. (Journal of Controlled Release, 353, 823-831).
- Kim, H., Yuk, S. A., Dieterly, A. M., Kwon, S., Park, J., Meng, F., Gadalla, H.H., Cadena, M.J., Lyle, L.T. and Yeo, Y. (2021). Nanosac, a noncationic and soft polyphenol nanocapsule, enables systemic delivery of siRNA to solid tumors. ACS nano, 15(3), 4576-4593.
- Elnaggar, M.G., Jiang, K., Eldesouky, H.E., Pei, Y., Park, J., Yuk, S.A., Meng, F., Dieterly, A.M., Mohammad, H.T., Hegazy, Y.A., Tawfeek, H.M., and Yeo, Y. 2020. Antibacterial nanotruffles for treatment of intracellular bacterial infection. Biomaterials, 262, 120344.
- Abouelmagd, S.A., Meng, F., Kim, B.K., Hyun, H., and Yeo, Y., 2016. Tannic acid-mediated surface functionalization of polymeric nanoparticles. ACS Biomaterials Science & Engineering, 2(12), 2294-2303.
- Qiu, Q., Deng, X., Jiao, L., Zhao, T., Meng, F., Huang, W. and Qian, H., 2015. A High-Sensitivity Coumarin-Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells. Chemical Biology & Drug Design, 86(2), 173-179.
- Asghar, S., Salmani, J.M.M., Hassan, W., Xie, Y., Meng, F., Su, Z., Sun, M., Xiao, Y. and Ping, Q., 2014. A facile approach for crosslinker free nano self-assembly of protein for anti-tumor drug delivery: Factors’ optimization, characterization, and in vitro evaluation. European Journal of Pharmaceutical Sciences, 63, 53-62
- Xiao, Y., Chen, X., Yang, L., Zhu, X., Zou, L., Meng, F. and Ping, Q., 2013. Preparation and oral bioavailability study of curcuminoid-loaded microemulsion. Journal of Agricultural and Food Chemistry, 61(15), 3654-3660.