Epigenetics, longevity, chromatin, molecular genetics
Epigenetics of longevity, Chromatin, Genetics, Cell Biology, Development
Our lab studies the epigenetics of complex traits: how genomes are packaged into chromatin, how chromatin landscapes are passed from one generation to the next, and how this transgenerational inheritance affects phenotypes like aging and fertility. Using the tractable model nematode C. elegans, we integrate molecular and classical genetic techniques with genomics and high-resolution microscopy.
Previously, we discovered that heritable changes in chromatin landscapes can have profound physiological consequences - for example, animals live longer when they inherit high levels of repressive chromatin from their ancestors. Future work will define how the transgenerational inheritance of chromatin affects gene expression throughout an organism's life cycle. These projects will allow us to uncover general principles of how heritable chromosome structure regulates gene expression. We think the best science is done in an inclusive and supportive environment, and welcome those from all backgrounds, at all training stages.