09/03/2024
By Thomas Wilson

Researchers are examining whether vitamin D and B12 can be introduced into the blood stream using oral dissolvable films (ODFs) compared to gummies.

The study team will explain the research in its entirety, but some details are:
• Participants will take part in three separate visits across 4 weeks.
• At visits 2 and 3 (3 weeks apart), participants will randomly assigned to consume either 2 gummies (Nature Made 5,000 IU Vitamin D and 1 gummie (Nature Made 1,000 micrograms, mcg vitamin B12) or two Nutrastrips Flash Release dissolvable oral strips containing 10,000 IU of Vitamin D and 1,000 mcg of B12.
• FIVE Fasting (8-hour) blood samples will be collected at each visit from the time of arrival and then at 10, 30, 60 and 180 minute intervals after you have consumed the supplement.

Who can participate?
• Generally healthy women (not pregnant) and men between the ages of 18 and 45.
• Willing to take a supplement.
• Willing to have multiple blood samples taken in a 3 hour period.
• Must have a normal body mass index between 18.5 – 30 kg/m2.
• You do not qualify if: you are unable to consent (adults lacking capacity); are not yet adults (infants, children, teenagers); are pregnant; a prisoner; have any medical condition requiring a doctor’s care including gastrointestinal disorders (e.g., gastroesophageal reflux disease (GERD), peptic ulcers, Crohn’s Disease), blood disorder (e.g., anemia, blood clotting conditions or on anticoagulant therapy), any known heart condition; you are prone to passing out during blood draws; you are allergic to any of the ingredients in the supplements or currently taking or have taken a vitamin D and B12 supplement within the last 30 days; you have a medical implanted device such as pacemakers, neurostimulators, and implantable defibrillators; weigh less than 110 pounds or have a body mass index (BMI) <18.5 OR >30 kg/m2.

Learn more about the by contacting Thomas Wilson, Ph.D. at Thomas_Wilson@uml.edu; 978-934-4509; Weed Hall room 202

IRB #: 24-008-WIL-XPD