This course covers the clinical and pathological aspects of human genetics with emphasis on prevention, diagnosis, and treatment of genetic diseases. Mendelian, cellular, and molecular genetics are reviewed, as is the metabolic basis of inherited diseases. Students learn principles of genetic counseling and how they integrate with other health care disciplines. These genetic counseling precepts are applied when students research and analyze a condition occurring in their own family, and write a report that embodies the results of this research. Following a review of DNA chemistry and dynamics, molecular alterations that cause human diseases is extensively discussed, including SNP activity, gene therapy techniques, and epigenetic mechanisms. Transcription and translation, the "switching on and off" of genes, and other DNA activity is discussed. The genetics of cancer, somatic cell genetics, and immunogenetics are integrated into genetic counseling. Laboratory techniques such as autoradiography, DNA extraction and analysis by electrophoresis, DNA profiling, automated DNA sequencing, RFLP analysis, PCR amplification, microarray analysis, and cloning methodology are presented. Pre-implantation diagnosis, germ-line alteration, and embryo cloning will also be discussed, along with their legal, ethical, and moral implications. Current progress on the Human Proteome, Transcriptome, and Kinome Projects will also be reported. Applications of genomics will be pervasive throughout the course. Meets Core Curriculum Essential Learning Outcome for Applied & Integrative Learning (AIL).
Junior or Senior Standing, and Applied Biomedical Sciences (BS), or Clinical Lab Sciences(BS), or Clinical Lab Minor, or Nutritional Sciences (BS), or Pharmaceutical Sciences (BS), or Public Health (BS).