This course will provide and introductory survey of the basis of theory/simulations of biomolecules. It is accessible to anyone who has completed two semesters of undergraduate chemistry and who has some background in physical chemistry. Topics/examples will be borrowed from modern biological chemistry and biophysics of single biomolecules. The course will be useful for senior undergraduates and beginning graduate students. Chem/Bioinformatics 84.567 will attempt to cultivate computational skills, which on needs to tackle current scientific problems of biology and biophysics.