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BIOL.5890 Practical Protein Crystallography (Formerly 81.589 & 81.489)

Id: 038015 Credits Min: 4 Credits Max: 4


This course provides grounding in the principles and practice of protein x-ray crystallography. The course will be unique in format and provide both didactic and laboratory instruction. It is comprised of a series of lecture and laboratory exercises, with an emphasis on practical techniques and hands-on experience of modern protein crystallography. The course will cover the fundamental knowledge about x-ray physics, instrumentation and geometrical diffraction, protein crystallization, macromolecular data collection and processing, phase estimation and improvement, model building and refinement, and model assessment. Student will also be given a recently published structural paper for writhing a report on the subject.


Pre-Req: 81.521 Biochemistry Techniques

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