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Peter Gaines

Peter Gaines
Peter C. GainesAssociate Professor
  • CollegeCollege of Sciences
  • DepartmentBiological Science
  • Phone(978) 934-2894
  • EmailPeter_Gaines@uml.edu

Research Interests

Molecular and Developmental Biology

Research in my laboratory is focused on analyzing the molecular signaling pathways that control blood cell differentiation. We are specifically interested in the development of the neutrophil, a phagocyte that plays a critical role in innate immunity. Neutrophil maturation occurs in the bone marrow, where pluripotent stem cells differentiate in response to cytokines released from sites of acute infection or inflammation. Importantly, disruption of neutrophil differentiation not only compromises immune responses but also underlies the pathogenesis of myelogenous leukemias. Using blood progenitor cell lines that can be induced to undergo maturation towards fully functional neutrophils, we are elucidating the molecular mechanisms that control neutrophil differentiation and functional activation using a combination of cell culture, molecular biology and biochemistry.

Education

  • Ph D: Molecular Genetics, (1996), Yale University - New Haven, Connecticut
    Dissertation/Thesis Title: Analysis of olfactory genes in Drosophila: small wing encodes a phospholipase C-gamma whose mutations activate the Sevenless pathway
  • BS: Biology, (1985), University of Vermont - Burlington, Vermont

Awards and Honors

  • Mentored Research Scientist K01 Award - National Institutes of Health
  • Postdoctoral Individual National Research Service Award - National Institutes of Health
  • Predoctoral Individual National Research Service Award - National Institutes of Mental Health
  • Teaching Excellence Award (2009), Teaching - University of Massachusetts Lowell Department of Biology
  • Exceeding Excellence in Teaching Award (2008), Teaching - University of Massachusetts Lowell College of Sciences
  • Mentored Research Scientist K01 Award (2002) - National Institutes of Health
  • Postdoctoral Individual National Research Service Award (1997) - National Institutes of Health
  • Predoctoral Individual National Research Service Award (1994) - National Institutes of Mental Health
  • Award Training Grant in Cell and Molecular Biology (1989) - National Research Service

Publications

  • Doig, D., Turner, E.L., Dobson, J., Featherstone, R.L., Lo, R.T., Gaines, P.A., Macdonald, S., Bonati, L.H., Clifton, A., Brown, M.M. () "Predictors of Stroke, Myocardial Infarction or Death within 30 Days of Carotid Artery Stenting: Results from the International Carotid Stenting Study," European Journal of Vascular and Endovascular Surgery
  • Aris, Z.F., Bouldin, R.M., Pelletier, M.G., Gaines, P.C., Budhlall, B., Nagarajan, R. (2017) "Microwave-assisted synthesis and characterization of hydrophilically functionalized polygalacturonic acid," Carbohydrate Polymers 155: pp. 432–439
  • Pelletier, M.G., Szymczak, K., Barbeau, A.M., Prata, G.N., O’Fallon, K.S., Gaines, P.C. (2016) "Characterization of neutrophils and macrophages from ex vivo-cultured murine bone marrow for morphologic maturation and functional responses by imaging flow cytometry.," Methods
  • Malu, K., Garhwal, R., Pelletier, M.G., Gotur, D., Halene, S., Zwerger, M., Zhong-Fa, Y., Rosmarin, A.G., Gaines, P.C. (2016) "Cooperative Activity of GABP with PU.1 or C/EBPe Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.," Journal of Immunology 197:3 pp. 910 - 922
  • Pelletier, M.G., Malu, K., Szymczak, K., Barbeau, A.M., Prata, G.N., O’Fallon, K.S., Gaines, P.C. (2016) "Critical Roles of A-Type Lamins in Neutrophil Differentiation Revealed By Analyses of Lmna Trancriptional Regulation and Myeloid Models with Aberrant Lamin A Expression," Blood 128:22 pp. 407–407
  • Schmidt, D., Reynaud, E., Gaines, P.C. (2016) "Responsive cell culture hydrogel,"
  • Gensicke, H., H. Bart van der Worp, ., Nederkoorn, P.J., Macdonald, S., Gaines, P.C., Aad van der Lugt, ., Willem P. Th M. Mali, ., Lyrer, P.A., Peters, N., Featherstone, R.L., J. de Borst, G., Engelter, S.T., Brown, M.M., Bonati, L.H. (2015) "Ischemic Brain Lesions After Carotid Artery Stenting Increase Future Cerebrovascular Risk," Journal of the American College of Cardiology 65:6 pp. 521-529
  • J. van Strijen, M., Grünhagen, T., Mauti, M., Zähringer, M., Gaines, P.C., Robinson, G.J., Railton, N.J., van Overhagen, H., Habraken, J., van Leersum, M. (2015) "Evaluation of a Noise Reduction Imaging Technology in Iliac Digital Subtraction Angiography: Noninferior Clinical Image Quality with Lower Patient and Scatter Dose," Journal of Vascular and Interventional Radiology 26:5 pp. 642-650.e1
  • Pal, A.K., Aalaei, I., Gadde, S., Gaines, P.C., Schmidt, D., Demokritou, P., Bello, D. (2014) "High resolution characterization of engineered nanomaterial dispersions in complex media using tunable resistive pulse sensing technology.," ACS nano 8:9 pp. 9003-15
  • Berczi, V., Bottomley, J.R., Gopalan, D., Griffiths, P.D., Gaines, P.C., Cleveland, T.J. (2014) "Absent right common carotid artery with stenting of symptomatic internal carotid artery stenosis," Journal of Vascular Surgery 59:5 pp. 1418-1421
  • Taylor, A., Tang, W., Bruscia, E., Zhang, P., Lin, A., Gaines, P., Wu, D., Halene, S. (2014) "SRF is required for neutrophil migration in response to inflammation," Blood 123:19 pp. 3027-3036
  • Gupta, D., Shah, H., Malu, K., Berliner, N., Gaines, P.C. (2014) "Differentiation and characterization of myeloid cells.," Current protocols in immunology / edited by John E. Coligan ... [et al.] 104: pp. Unit 22F.5.
  • Pal, A., Hsieh, S., Khatri, M., Isaacs, J., Demokritou, P., Gaines, P., Schmidt, D., Rogers, E., Bello, D. (2014) "Screening for oxidative damage by engineered nanomaterials: A comparative evaluation of FRAS and DCFH," Journal of Nanoparticle Research 16:2
  • Pal, A.K., Hsieh, S., Khatri, M., Isaacs, J.A., Demokritou, P., Gaines, P.C., Schmidt, D., Rogers, E.J., Bello, D. (2014) "Screening for oxidative damage by engineered nanomaterials: a comparative evaluation of FRAS and DCFH," Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology 2 pp. 1
  • Khatri, M., Bello, D., Gaines, P.C., Martin, J., Pal, A.K., Gore, R., Woskie, S. (2013) "Nanoparticles from photocopiers induce oxidative stress and upper respiratory tract inflammation in healthy volunteers," Nanotoxicology 7:5 pp. 1014–1027
  • Gaines, P.C., M., K., Bello, D., Martin, J., Pal, A., Gore, R., Woskie, S. (2013) "Nanoparticles from photocopiers induce oxidative stress and upper respiratory tract inflammation in healthy volunteers,"
  • Gaines, P.C., S.F., S., Garhwal, R., Leahy, C., Ellis, E., Crawford, K., Schmidt, D., McCarthy, S. (2013) "Synthesis and characterization of pullulan-b-PCL core-shell nanospheres encapsulated with ciprofloxacin,"
  • Khatri, M., Bello, D., Pal, A., Woskie, S., Gassert, T., Demokritou, P., Gaines, P. (2013) "Toxicological effects of PM0.25-2.0 particles collected from a photocopy center in three human cell lines," Inhalation Toxicology 25:11 pp. 621-632
  • Khatri, M., Bello, D., Pal, A.K., Cohen, J.M., Woskie, S., Gassert, T., Lan, J., Gu, A.Z., Demokritou, P., Gaines, P.C. (2013) "Evaluation of cytotoxic, genotoxic and inflammatory responses of nanoparticles from photocopiers in three human cell lines.," Particle and fibre toxicology 10:1 pp. 42
  • Shady, S., Gaines, P., Garhwal, R., Leahy, C., Ellis, E., Crawford, K., Schmidt, D., McCarthy, S. (2013) "Synthesis and characterization of pullulan-polycaprolactone core-shell nanospheres encapsulated with ciprofloxacin," Journal of Biomedical Nanotechnology 9:9 pp. 1644-1655
  • Subramanian, G., Chaudhury, P., Malu, K., Fowler, S., Manmode, R., Gotur, D., Zwerger, M., Ryan, D., Roberti, R., Gaines, P.C. (2012) "Lamin B receptor regulates the growth and maturation of myeloid progenitors via its sterol reductase domain: Implications for cholesterol biosynthesis in regulating myelopoiesis," Journal of Immunology 188:1 pp. 85-102
  • Subramanian, G., Chaudhury, P., Malu, K., Fowler, S., Manmode, R., Gotur, D., Zwerger, M., Ryan, D., Roberti, R., Gaines, P.C. (2012) "Lamin B receptor regulates the growth and maturation of myeloid progenitors via its sterol reductase domain: Implications for cholesterol biosynthesis in regulating myelopoiesis," Journal of Immunology 188:1 pp. 85-102
  • Patil, S., Chaudhury, P., Clarizia, L., McDonald, M., Reynaud, E., Gaines, P.C., Schmidt, D.F. (2012) "Responsive hydrogels produced via organic sol-gel chemistry for cell culture applications," Acta Biomaterialia 8:8 pp. 2919-2931
  • Patil, S., Chaudhury, P., Clarizia, L., McDonald, M., Reynaud, E., Gaines, P.C., Schmidt, D.F. (2012) "Responsive Hydrogels Produced via Organic Sol-Gel Chemistry for Cell Culture Applications," Acta Biomaterialia 8:8 pp. 2919-2931
  • Garhwal, R., Shady, S.F., Ellis, E.J., Ellis, J.Y., Leahy, C.D., Mccarthy, S.P., Crawford, K.S., Gaines, P.C. (2012) "Sustained ocular delivery of ciprofloxacin using nanospheres and conventional contact lens materials," Investigative Ophthalmology and Visual Science 53:3 pp. 1341-1352
  • Halene, S., Gaines, P.C., Sun, H., Zibello, T., Lin, S., Khanna-Gupta, A., Williams, S.C., Perkins, A., Krause, D., Berliner, N. (2010) "C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx," Experimental hematology 38:2 pp. 90-103
  • Garhwal, R., Yang, Z., Rosmarin, A.G., Gaines, P.C. (2010) "GA Binding Protein Transcriptionally Regulates the Lamin B Receptor Gene: Insight into the Progression of Myelodysplasia," Blood 116:21
  • Bonati, L.H., Jongen, L.M., Haller, S., Flach, H.Z., Dobson, J., Nederkoorn, P.J., Macdonald, S., Gaines, P.C., Waaijer, A., Stierli, P., J?ger, H.R., Lyrer, P.A., Kappelle, L.J., Wetzel, S.G., van der Lugt, A., Mali, W.P., Brown, M.M., van der Worp, H.B., Engelter, S.T. (2010) "New ischaemic brain lesions on MRI after stenting or endarterectomy for symptomatic carotid stenosis: a substudy of the International Carotid Stenting Study (ICSS)," The Lancet Neurology 9:4 pp. 353-362
  • Gaines, P.C. (2010) "New protocols for generating induced pluripotent stem cells," Regenerative Medicine 5: pp. 501-502
  • Gaines, P.C., Liu, R., Park, I. (2010) "Research highlights.," Regenerative medicine 5:4
  • Subramanian, G., Chaudhury, P., Gaines, P.C. (2010) "The Lamin B Receptor Provides Sterol Reductase Activities Critical to Neutrophil Development: Implications for Cholesterol Biosynthesis In Regulating Myelopoiesis," Blood 116:21
  • Ederle, J., Bonati, L.H., Dobson, J., Featherstone, R.L., Gaines, P.C., Beard, J.D., Venables, G.S., Markus, H.S., Clifton, A., Sandercock, P., Brown, M.M. (2009) "Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial," The Lancet Neurology 8:10 pp. 898-907
  • Lee, H., Park, J., Forget, B.G., Gaines, P.C. (2009) "Induced pluripotent stem cells in regenerative medicine: An argument for continued research on human embryonic stem cells," Regenerative Medicine 4:5 pp. 759-769
  • Bonati, L.H., Ederle, J., McCabe, D.J., Dobson, J., Featherstone, R.L., Gaines, P.C., Beard, J.D., Venables, G.S., Markus, H.S., Clifton, A., Sandercock, P., Brown, M.M. (2009) "Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial," The Lancet Neurology 8:10 pp. 908-917
  • Willaert, W., Aggarwal, R., Van Herzeele, I., O'Donoghue, K., Kabbar, M., Gaines, P.C., Vermassen, F., Darzi, A., Cheshire, N. (2009) "PP23. Patient Specific Endovascular Simulation Influences the Material Selection of All Interventionalists Performing a Carotid Artery Stent Procedure," Journal of Vascular Surgery 49:5, Supplement
  • Garhwal, R., Rosmarin, A.G., Halene, S., Gaines, P.C. (2009) "Transcriptional Regulation of the Nuclear Envelope Lamin B Receptor: New Roles for GA Binding Protein (GABP) in Neutrophil Development.," Blood 114:22
  • Gaines, P.C., Lamoureux, J., Marisetty, A., Chi, J., Berliner, N. (2008) "A cascade of Ca2+/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils," Experimental hematology 36:7 pp. 832-844
  • Gaines, P.C., Gotur, D., Halene, S., Olins, A.L., Olins, D.E. (2008) "Dynamic Expression of the Lamin B Receptor and Associated Proteins during Myeloid Differentiation: Insight into Mechanisms of Neutrophil Vs. Macrophage Morphogenesis," Blood 112:11
  • Zwerger, M., Herrmann, H., Gaines, P.C., Olins, A.L., Olins, D.E. (2008) "Granulocytic nuclear differentiation of lamin B receptor-deficient mouse EPRO cells," Experimental hematology 36:8 pp. 977-987
  • Gaines, P.C., Tien, C.W., Olins, A.L., Olins, D.E., Shultz, L.D., Carney, L., Berliner, N. (2008) "Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses," Experimental hematology 36:8 pp. 965-976
  • Gaines, P.C., Nicholson, T. (2006) "A suggested training programme for carotid artery stenting (CAS)," European Journal of Radiology 60:1 pp. 37-39
  • Gaines, P.C., Berliner, N. (2006) "Granulopoiesis," Clinical Hematology, Elsevier, Inc.
  • Berczi, V., Thomas, S.M., Turner, D.R., Bottomley, J.R., Cleveland, T.J., Gaines, P.C. (2006) "Stent Implantation for Acute Iliac Artery Occlusions: Initial Experience," Journal of Vascular and Interventional Radiology 17:4 pp. 645-649
  • Berczi, V., Elfleet, E., Turner, D., Cleveland, T.J., Gaines, P.C. (2005) "Adverse Cardiac Events as a Result of High Volume Contrast Injection during Rotational Arch Aortography," Journal of Vascular and Interventional Radiology 16:4 pp. 558-559
  • Gaines, P.C., Berliner, N., J.E., C., B., B., D.H., M., E.M., S., W., S., R., C. (2005) "Differentiation and characterization of myeloid cells," W. John Wiley & Sons, Inc. U22F.5:
  • Gaines, P.C., Berliner, N., Chi, J. (2005) "Heterogeneity of functional responses in differentiated myeloid cell lines reveals EPRO cells as a valid model of neutrophil functional activation," Journal of Leukocyte Biology 77: pp. 669-679
  • , P., N.A., M., Khanna-Gupta, A., Zibello, T., Enriquez, L., Enriquez, L., Goldberg, L., Berliner, N. (2004) "G-CSF signaling can differentiate promyelocytes expressing a defective retinoic acid receptor: Evidence for divergent pathways regulating neutrophil differentiation," 103: pp. 1693-1701
  • Gaines, P.C., A., K., Zebello, T., Sun, H., Berliner, N. (2003) "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP and C/EBP ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression.," 101: pp. 3460-3468
  • Kaul, P., Kay, S., Gaines, P.C., Suvarna, S.K., Hopkinson, D.N., Rocco, G. (2003) "Giant pleural fibroma with an abdominal vascular supply mimicking a pulmonary sequestration," The Annals of Thoracic Surgery 76:3 pp. 935-937
  • Tan, K.T., Cleveland, T.J., Berczi, V., McKevitt, F.M., Venables, G.S., Gaines, P.C. (2003) "Timing and frequency of complications after carotid artery stenting: what is the optimal period of observation?," Journal of Vascular Surgery 38:2 pp. 236-243
  • Gaines, P.C., Berliner, N. (2003) "Retinoids in Myelopoiesis," pp. 46-65
  • Patel, J.V., Rossbach, M.M., Cleveland, T.J., Gaines, P.C., Beard, J.D. (2002) "Endovascular Stent-Graft Repair of Traumatic Carotid Artery Pseudoaneurysm," Clinical radiology 57:4 pp. 308-311
  • Al-Mubarak, N., Colombo, A., Gaines, P.C., Iyer, S.S., Corvaja, N., Cleveland, T.J., Macdonald, S., Brennan, C., Vitek, J.J. (2002) "Multicenter evaluation of carotid artery stenting with a filter protection system," Journal of the American College of Cardiology 39:5 pp. 841-846
  • Macdonald, S., Venables, G.S., Cleveland, T.J., Gaines, P.C. (2002) "Protected carotid stenting: Safety and efficacy of the MedNova NeuroShield filter," Journal of Vascular Surgery 35:5 pp. 966-972
  • Gaines, P.C., T.J., P., Geiger, J., Miller, C., Zhang, D., Wojchowski, D. (2001) "Integrative signaling by minimal EPO receptor forms and C-kit.," 276: pp. 8995-9002
  • Gaines, P.C., Geiger, J., Knudsen, G., Panek, L., Pandit, A., Yoder, M., Lord, K., Creasy, C., Burns, B., Dillon, S., Wojchowski, D. (2001) "mDYRK3 Kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development.," 97: pp. 901-910
  • Gaines, P.C., Geiger, J., Knudsen, G., Seshasayee, D., Wojchowski, D. (2000) "GATA-1 and FOG-dependent activation of megakaryocytic alpha IIB gene expression.," 275: pp. 34114-21
  • Gaines, P.C., D., S., Geiger, J., Wojchowski, D. (2000) "Intron 1 elements promote erythroid-specific GATA-1 gene expression.," 275: pp. 22969-77
  • Gaines, P.C., Tompkins, L., Woodard, C., Carlson, J. (2000) "quick-to-court, a Drosophila mutant with elevated levels of sexual behavior, is defective in a predicted coiled-coil protein.," 154: pp. 1627-1637
  • Gregory, R.C., Lord, K.A., Panek, L.B., Gaines, P.C., Dillon, S.B., Wojchowski, D.M. (2000) "SUBTRACTION CLONING AND INITIAL CHARACTERIZATION OF NOVEL EPO-IMMEDIATE RESPONSE GENES," Cytokine 12:7 pp. 845-857
  • Gaines, P.C., Woodard, C.T., Carlson, J.R. (1999) "An enhancer trap line identifies the Drosophila homolog of the L37a ribosomal protein," Gene 239:1 pp. 137-143
  • Powe Jr., A.C., Strathdee, D., Cutforth, T., D'Souza-Correia, T., Gaines, P.C., Thackeray, J., Carlson, J., Gaul, U. (1999) "In vivo functional analysis of Drosophila Gap1: involvement of Ca2+ and IP4 regulation," Mechanisms in development 81:1?"2 pp. 89-101
  • Gaines, P.C., Wojchowski, D. (1999) "plRES-CD4t, a dicistronic expression vector for MACS- or FACS-based selection of transfected cells.," 26: pp. 683-688
  • Gaines, P.C., Freeman, M., Dobritsal, A., Segraves, W., Carlson, J. (1999) "The dare gene: Steroid hormone production, olfactory behavior, and neural degeneration in Drosophila.," 126: pp. 4591-4602
  • Gaines, P.C., Thackery, J., Ebert, P., Carlson, J. (1998) "small wing encodes a phospholipase C- that acts as a negative regulator of R7 development in Drosophila.," 125: pp. 5033-5042
  • Brown, M.M., Venables, G., Clifton, A., Gaines, P.C., Taylor, R.S. (1997) "Carotid endarterectomy vs carotid angioplasty," The Lancet 349:9055 pp. 880-881
  • Gaines, P.C., D., S., Wojchowski, D. (1997) "GATA-1 dominantly activates a program of erythroid gene expression in factor-dependent myeloid FDCW2 cells.," 18: pp. 3278-3288
  • Dyet, J.F., Gaines, P.C., Nicholson, A.A., Cleveland, T., Cook, A.M., Wilkinson, A.R., Galloway, J.M., Beard, J. (1997) "Treatment of Chronic Iliac Artery Occlusions by Means of Percutaneous Endovascular Stent Placement," Journal of Vascular and Interventional Radiology 8:3 pp. 349-353
  • Gaines, P.C., Carlson, J. (1995) "The olfactory and visual systems are closely related in Drosophila. ," 28: pp. 161-167
  • Gaines, P.C., McKenna, M., Hekmat-Scafe, D., Carlson, J. (1994) "Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system.," 269: pp. 16340-16347
  • Gaines, P.C. (1993) "119 pages Douglas M. Cavaye, Rodney A. White, Intravascular Ultrasound Imaging (1993) Raven Press,St Louis.," European journal of vascular surgery 7:6 pp. 756-757
  • Siegel, R.J., Gaines, P.C., Crew, J.R., CumberlandM, D.C. (1993) "Clinical trial of percutaneous peripheral ultrasound angiopalsty," Journal of the American College of Cardiology 22:2 pp. 480-488
  • Siegel, R.J., Gaines, P.C., Procter, A., Fischell, T.A., Cumberland, D.C. (1992) "Clinical demonstration that catheter-delivered ultrasound energy reverses arterial vasoconstriction," Journal of the American College of Cardiology 20:3 pp. 732-735
  • Gaines, P.C., Riesgo-Escovar, J., Woodard, C., Carlson, J. (1992) "Development and organization of the Drosophila olfactory system: An analysis using enhancer traps.," 23: pp. 947-964
  • Gaines, P.C., Hughes, K., Karlinsey, J., Vinayak, R., Simon, M. (1992) "Sequence-specific interaction of the Salmonella Hin Recombinase in both major and minor grooves of DNA.," 11: pp. 2695-2705

Presentations

  • Photostable bioimaging probes via pickering emulsions. - 86th ACS Colloid & Surface Science Symposium, June 2012 - Baltimore, MD.
  • Ex vivo cultured mouse bone marrow to identify differentially expressed nuclear proteins during myeloid cell maturation - Eastern New England Biological Conference, April 2012 - Easton, MA
  • Nanoparticles from photocopiers induce upper airway inflammation in exposed controls and chronically exposed workers. - Fifth International Symposium on Nanotechnology - Occupational and Environmental Health, August 2011 - Boston, MA
  • Murine CAE Model for Efficient Screening of Novel Therapeutics for Dry Eye Syndrome. - Association for Research in Vision and Ophthalmology Meeting, May 2011 - Fort Lauderdale, FL
  • GA Binding Protein Transcriptionally Regulates the Lamin B Receptor Gene: Insight Into the Progression of Myelodysplasia, December 2010 - Orlando, FL
  • The Lamin B Receptor Provides Sterol Reductase Activities Critical to Neutrophil Development. - Implications for Cholesterol Biosynthesis in Regulating Myelopoiesis., December 2010 - Orlando, FL
  • Comparative Assessment of Murine Allergic Conjunctivitis Model Variations for Efficient Pre-Clinical Screening. - Association for Research in Vision and Ophthalmology Meeting, May 2010 - Fort Lauderdale, FL
  • Sustained Antibiotic Delivery from Nanospheres within Contact Lens Hydrogels. - Association for Research in Vision and Ophthalmology Meeting, May 2010 - Fort Lauderdale, FL
  • Transcriptional Regulation of the Nuclear Envelop Lamin B Receptor: New Roles for GA Binding Protein (GABP) in Neutrophil Development., December 2009 - New Orleans, LA
  • A mouse model of Pelger-Huet anomaly identifies unique roles for the lamin B receptor and cholesterol biosythesis in neutrophil development & function. - Minary Regional Hematopoiesis Workshop, November 2009
  • A novel Ca2+/calmodulin-dependent protein kinase cascade regulates blood stem cell growth & development. - Eastern New England Biological Conference, April 2009 - Lowell, MA
  • Critical roles for the nuclear envelop protein lamin B receptor in neutrophil development. - Eastern New England Biological Conference, April 2009 - Lowell, MA
  • Critical roles for the nuclear envelop protein lamin B receptor in neutrophil development. - Eastern New England Biological Conference, April 2009 - Lowell, MA
  • Transcriptional Regulation of the Nuclear Envelop Lamin B Receptor in myeloid cells - Eastern New England Biological Conference, April 2009 - Lowell, MA
  • Dynamic Expression of the Lamin B Receptor and Associated Proteins during Myeloid Differentiation: Insight into Mechanisms of Neutrophil vs. Macrophage Morphogenesis., December 2008 - San Francisco, CA
  • Hypolobulation in neutrophils with severe PelgerHuet anomaly causes defective chemotaxis. - Eastern New England Biology Conference, April 2008
  • Studies of a Novel Murine Cell Line Model of Pelger-Huet Anomaly Reveals Critical Roles for the Lamin B receptor in the Development and Function of Neutrophils. - Seventh International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, May 2007 - Annapolis, MD
  • C/EBP knockout(KO) EML and PBilM cell lines replicate the in vivo phenotype of the C/EBP KO mouse., December 2005 - San Diego, CA
  • Infection with Anaplasma phagocytophilum inhibits proliferation and differentiation of myeloid progenitors: New insight into infection-related pancytopenia., December 2005 - San Diego, CA
  • The Estrogen-Responsive B Box Protein(EBBP) is directly up-regulated by the combinatorial actions of cytokine- and retinoic acid-induced differentiation in myeloid progenitors. - 5th International Meeting on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, December 2003 - Annapolis, MD
  • Heterogeneity of functional maturation programs in inducible models of myeloid differentiation., December 2003 - San Diego, CA
  • Overexpression of constitutively active calcium/calmodulin-dependent protein kiinases in ATRA-induced EPRO cells abrogates neutrophil functional responses., December 2003 - San Diego, CA
  • Constitutive overexpression of calcium/calmodulin-dependent protein kinase kinase alpha in 32Dcl3 myeloid cells disrupts G-CSF-induced proliferative and survival signals., December 2001 - Orlando, FL
  • Constitutive overexpression of the retinoic acid responsive calcium/calmodulin-dependent protein kinase kinase alpha disrupts G-CSF-induced responses in 32Dcl3 myeloid cells. - 4th International meeting on Molecular Aspects of Myeloid Stem Cell Development , April 2001 - Annapolis, MD
  • Critical concentrations of FOG are required for alpha-IIb gene activation via both GATA-1-dependent and -independent mechanisms., December 1999 - New Orleans, LA
  • Activities of a minimal Epo receptor chimera in transgenic mice, and subtraction cloning and initial characterization of novel Epo-response genes. - Cold Spring Harbor 64th Symposium: Signaling and Gene Expression in the Immune System, June 1999 - Cold Spring Harbor, NY
  • Substration cloning and initial characterization of novel Epo-response genes., December 1998 - Miami, FL
  • Co-expression of GATA-1 and the Epo receptor in myeloid FDCW2 cell prolongs the cell cycle at G1, attenuates proliferation and activates endogenous erythroid gene expression., December 1997 - San Diego, CA
  • GATA-1 activates erythroid differentiation and inhibits growth upon ecotopic co-expression with the Epo receptor in myeloid FDCW2 cells. - Keystone Symposia on Molecular and Cellular Biology, February 1997 - Tammarron, CO
  • small wing encodes a phopholipase C-gamma whose mutations activate the Sevenless receptor tyrosine kinase pathway. - Cold Spring Harbor Symposium on Drosophila Neurobiology, May 1995 - Cold Spring Harbor, NY
  • Molecular and genetic analysis of Drosophila olfaction. - International Symposium on Olfaction and Taste XI, June 1993 - Sapporo, Japan
  • The functional organization of the olfactory system: An analysis using region-specific genes. - 34th Annual Drosophila Research Conference, March 1993 - San Diego, CA
  • A screen for olfactory genes using enhancer detectors. - 32nd Annual Drosophila Research Conference, March 1991 - Chicago, IL
  • Molecular characteriztion of an olfactory system cDNA. - 32nd Annual Drosophila Research Conference, March 1991 - Chicago, IL

Contracts, Fellowships, Grants and Sponsored Research

  • Regulation and function of nuclear envelope proteins in myelopoiesis and leukemia (2010), Grant -
    Gaines, P.C. (Principal)
  • Regulation and Function of Nuclear Envelope Proteins in Myelopoiesis and Leukemia (2010), Grant - National Institutes of Health; National Heart, Lung and Blood Institute; R15 Academic Research Enhancement Award
    Gaines, P. (Principal)
  • Feasibility of Contrast Enhanced Neutron Imaging for the Early and Accurate Clinical Detection of Disease (2010), Grant - Life Science Moment Fund Award, University of Massachusetts Worcester
    Gaines, P. (Co-Principal)
  • Allergy Model Pilot Studies (2009), Grant - Ophthalmic Research Associates (Ora)
    Gaines, P. (Principal)
  • Allergy Model Pilots at UML/Gaines Laboratory (2009), -
    Gaines, P.C. (Principal)
  • Bacteria Studies (2010), -
    Gaines, P.C. (Principal)
  • Opthalmic Hydrogel Bacteria Studies (2010), Grant - Vista Scientific, funded from National Institutes of Health, National Eye Institute
    Gaines, P. (Principal)
  • Nanosphere-Antibiotic Corneal Contact Lens Delivery System (2009), Grant - Vista Scientific, funded from National Institutes of Health, National Eye Institute
    Gaines, P. (Co-Principal)
  • Role of Lamin B Receptor in Neutrophil Maturation and Functional Activation (2007), Grant - National Institutes of Health; National Heart, Lung and Blood Institute; R15 Academic Research Enhancement Award
    Gaines, P. (Principal)
  • Novel Hydrogel-Based System for Maintenance of Mammalian Cells in Culture (2009), - Millipore Corporation
    Gaines, P. (Co-Principal)