03/19/2024
By Kwok Fan Chow
The Kennedy College of Science, Department of Chemistry, invites you to attend a Ph.D. Dissertation defense by Dang V. Truong entitled “Antimicrobial Activity of Auranofin Analogs and the Underlyin Mechanism.”
Degree: Doctoral
Date: Tuesday, March 26, 2024
Time: 9 a.m.
Location: Olney Room 518
Committee:
- Chair Mingdi Yan, Department of Chemistry, University of Massachusetts Lowell
- Olof Ramstrom, Department of Chemistry, University of Massachusetts Lowell
- Matthew Gage, Department of Chemistry, University of Massachusetts Lowell
- Guixin He, Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell
Abstract:
Due to the improper use and prescription of antibiotics, global communities and healthcare systems are confronted with a critical challenge: the development of antibiotic resistance. With limited new antimicrobial agents being developed by private industry and pharmaceutical companies, researchers and government agencies are turning to drug repurposing strategies to reduce the time and cost of development. Auranofin, an FDA-approved drug, has been repurposed as an active agent for cancer treatment, antimicrobial drugs, and many other applications. Auranofin demonstrates enhanced bactericidal activity against Gram-positive bacteria, but its effect against Gram-negative bacteria is limited. My research proposes new strategies to enhance auranofin’s antimicrobial activity, either through dosage combination with thiourea or through structural modification.
All interested students and faculty members are invited to attend.