04/11/2023
By Javier Horta
Michael Brehm will speak on Wednesday, April 12 at 3:30 p.m. in Coburn G30 and provide an overview of immunodeficient mouse strains for humanization, then focusing on
- Engraftment of human immune systems in humanized models
- Testing immunogenicity of stem cell-derived pancreatic beta cells in humanized mice
- Next generation of humanized mice
Brehm received his Ph.D. in 1999 from the Department of Microbiology and Immunology at the Pennsylvania State University College of Medicine. During Brehm’s post-doctoral training at the University of Massachusetts Chan Medical School (UMCMS), he investigated how sequential viral infections impact the ability of a host to generated protective immunity and how viral infections influence transplantation tolerance that is induced by co-stimulation blockade. In 2008, he joined the Diabetes Division at the UMCMS to develop cutting edge mouse models to study human biology.