03/31/2022
By Suzanne Young

The Kennedy College of Science, Department of Chemistry, invites you to attend a Master's thesis defense by Scott Rich entitled “Development of an Anti-Idiotypic Antibody to a Visterra Biomolecule.” 

The defense will be held on April 12th at 12:30 p.m. by Zoom. Please contact Suzanne Young for meeting information if you are interested in attending. 

The committee will be composed of 

  • Matt Gage (chair)
  • Jin Xu
  • Susan Sloan 

Abstract: As a focus of recent pharmaceutical efforts, fully humanized antibodies created a new challenge for assessing drug pharmacokinetics. Anti-idiotype antibodies offer the ability to accurately detect therapeutics in human samples and characterize the presence or magnitude of an anti-drug antibody response. This thesis details the immunization strategy for a therapeutic-specific anti-idiotype, and the selection of a top candidate informed by antibody characterizations. The anti-idiotype candidates were evaluated for suitability as a critical reagent in pharmaceutical bioanalytical assay designs.

All interested students and faculty members are invited to attend.