04/06/2021
By Matthew Gage

The Kennedy College of Science, Department of Chemistry, invites you to attend a master's thesis defense by Kourosh Ghamary entitled “Development of In-Silico Designed Antibodies using Yeast Surface Display Technology.” The defense will be held on Tuesday, April 20 at 5 p.m. by Zoom. Please contact Matthew Gage for meeting information if you are interested in attending. The committee will be composed of Matthew Gage (chair), Jin Xu and Karthik Viswanathan. A brief abstract is provided below.

Abstract: In-silico design methods utilizing global antibody docking were employed to engineer a sequence repertoire that could be experimentally constructed and tested. The Dock-and-Design library created by Viserra’s computational team was interrogated for antibody binders to Antigen A using yeast surface display technology. Identified hits were expressed and purified as full-length IgG in human embryonic kidney cells and tested for binding against Antigen A. Results indicate that computationally designed antibodies can be engineered to bind to targets of interest.

All interested students and faculty members are invited to attend.