04/06/2021
By Matthew Gage
Abstract: In-silico design methods utilizing global antibody docking were employed to engineer a sequence repertoire that could be experimentally constructed and tested. The Dock-and-Design library created by Viserra’s computational team was interrogated for antibody binders to Antigen A using yeast surface display technology. Identified hits were expressed and purified as full-length IgG in human embryonic kidney cells and tested for binding against Antigen A. Results indicate that computationally designed antibodies can be engineered to bind to targets of interest.
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