04/12/2021
By Susan Pryputniewicz
The Biomedical Engineering and Biotechnology Program invites you to attend a proposal defense by Karen Gelinas-Roa on “The Impact of Lipid Nanoparticles containing mRNA on Human Derived Glioma Cells.”
Ph.D. Candidate: Karen Gelinas-Roa
Date: Monday, April 26, 2021
Time: 1 to 2 p.m.
Location: This will be a virtual defense via Zoom. Those interested in attending should contact the student Karen_Roa@uml.edu and committee advisor Thomas_Wilson@uml.edu at least 24 hours prior to the defense to request access to the meeting.
Committee Chair (Advisor): Thomas Wilson, Ph.D., Associate Professor, Biomedical and Nutritional Sciences, University of Massachusetts Lowell
Committee Members:
- Shannon Kelleher, Ph.D., Professor, Biomedical and Nutritional Sciences, University of Massachusetts Lowell
- Jonghan Kim, Ph.D., Associate Professor, Pharmaceutical Sciences, University of Massachusetts Lowell
- Srikanth Kakumanu, Ph.D., Precision Nanosystems Inc.
Abstract:
Glioblastoma multiforme (GBM), which is considered one of the most aggressive forms of glioma and has a survival rate of 15 to 18 months from the date of diagnosis. The combined nanoparticle technology expects an improvement in delivery through the blood brain barrier, with lipid nanoparticles (LNPs) and the use on messenger RNA (mRNA). mRNA stability is determined by a combination of general and specific structures and pathways. The LNPs which will produce are ionizable cationic lipids, to help avoid toxicity associated with permanently cationic lipoplexes, and are highly effective gene delivery vehicles.
All interested students and faculty members are invited to attend the online defense via remote access.