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Chung-Dar Lu

Lu-ChungDar
Chung-Dar LuProfessor, Clinical Science Program Director
  • CollegeZuckerberg College of Health Sciences
  • DepartmentBiomedical & Nutritional Sciences
  • EmailChungDar_Lu@uml.edu

Education

  • Ph D, (1991), Dept. of Clinical Laboratory and Nutritional Sciences, UMass Lowell. - Georgia State University
  • BS: Medical Technology, (1984), National Yang-Ming University - Taiwan

Publications

  • Guoqing, L., Lu, C. (2016) "Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.," Microbiology 7 pp. 1232
  • Indurthi, S.M., Han-Ting, C., Lu, C. (2016) "Molecular characterization of lysR-lysXE, gcdR-gcdHG and amaR-amaAB operons for lysine export and catabolism: a comprehensive lysine catabolic network in Pseudomonas aeruginosa PAO1.," Microbiology 5 pp. 876
  • Li, G., Lu, C. (2016) "The Cryptic dsdA Gene Encodes a Functional d-Serine Dehydratase in Pseudomonas aeruginosa PAO1.," Current Microbiology 72:6 pp. 788 - 794
  • Yan, Y., Yao, X., Li, H., Zhou, Z., Huang, W., Stratton, C.W., Lu, C., Tang, Y. (2014) "A novel Pseudomonas aeruginosa strain with an oprD mutation in relation to a nosocomial respiratory infection outbreak in an intensive care unit," Journal of clinical microbiology 52:12 pp. 4388-4390
  • Chou, H.T., Li, J., Lu, C. (2014) "Functional characterization of the agtABCD and agtSR operons for 4-aminobutyrate and 5-aminovalerate uptake and regulation in Pseudomonas aeruginosa PAO1," Current microbiology 68:1 pp. 59–63
  • Yang, C., Tai, P.C., Lu, C. (2014) "Time-related transcriptome analysis of B. subtilis 168 during growth with glucose," Current microbiology 68:1 pp. 12–20
  • He, W., Li, G., Yang, C., Lu, C. (2014) "Functional characterization of the dguRABC locus for D-Glu and d-Gln utilization in Pseudomonas aeruginosa PAO1," Microbiology (Reading, England) 160: pp. 2331-2340
  • Yao, X., Lu, C. (2014) "Characterization of Staphylococcus aureus responses to spermine stress," Current microbiology 69:3 pp. 394-403
  • Yao, X., Lu, C. (2014) "Functional characterization of the potRABCD operon for spermine and spermidine uptake and regulation in Staphylococcus aureus," Current microbiology 69:1 pp. 75-81
  • Yang, C., Lu, C., Tai, P.C. (2013) "Differential expression of secretion machinery during Bacterial growth: SecY and SecF decrease while SecA increases during transition from exponential phase to stationary phase," Current microbiology 67:6 pp. 682–687
  • Chou, H.T., Li, J., Peng, Y., Lu, C. (2013) "Molecular characterization of PauR and its role in control of putrescine and cadaverine catabolism through the $?$-glutamylation pathway in Pseudomonas aeruginosa PAO1," Journal of bacteriology 195:17 pp. 3906–3913
  • Yao, X., Li, C., Zhang, J., Lu, C. (2012) "," Antimicrobial agents and chemotherapy 56:10 pp. 5309–5314
  • Yao, X., Lu, C. (2012) "A PBP 2 Mutant Devoid of the Transpeptidase Domain Abolishes Spermine–$ß$-Lactam Synergy in Staphylococcus aureus Mu50," Antimicrobial agents and chemotherapy 56:1 pp. 83–91
  • Yao, X., He, W., Lu, C. (2011) "Functional characterization of seven $?$-glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and $ß$-alanine utilization in Pseudomonas aeruginosa PAO1," Journal of bacteriology 193:15 pp. 3923–3930
  • Yang, C., Ewis, H.E., Zhang, X., Lu, C., Hu, H., Pan, Y., Abdelal, A.T., Tai, P.C. (2011) "Nonclassical protein secretion by Bacillus subtilis in the stationary phase is not due to cell lysis," Journal of bacteriology 193:20 pp. 5607–5615
  • Abdou, L., Chou, H., Haas, D., Lu, C. (2011) "Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa," Journal of bacteriology 193:11 pp. 2784–2792
  • He, W., Li, C., Lu, C. (2011) "Regulation and characterization of the dadRAX locus for D-amino acid catabolism in Pseudomonas aeruginosa PAO1," Journal of bacteriology 193:9 pp. 2107–2115
  • Li, C., Lu, C. (2009) "Arginine racemization by coupled catabolic and anabolic dehydrogenases," Proceedings of the National Academy of Sciences 106:3 pp. 906–911
  • Ni, N., Choudhary, G., Peng, H., Li, M., Chou, H., Lu, C., Gilbert, E.S., Wang, B. (2009) "Inhibition of quorum sensing in Vibrio harveyi by boronic acids," Chemical biology & drug design 74:1 pp. 51–56
  • Li, C., Wally, H., Miller, S.J., Lu, C. (2009) "Multifaceted MvaT and MvaU of the H-NS Homologues in Control of Arginine Metabolism, Pyocyanin Synthesis, and Prophage Activation in Pseudomonas aeruginosa PAO1," Journal of Bacteriology
  • Peng, H., Cheng, Y., Ni, N., Li, M., Choudhary, G., Chou, H.T., Lu, C., Tai, P.C., Wang, B. (2009) "Synthesis and evaluation of new antagonists of bacterial quorum sensing in Vibrio harveyi," ChemMedChem 4:9 pp. 1457–1468
  • Li, C., Wally, H., Miller, S.J., Lu, C. (2009) "The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1," Journal of bacteriology 191:20 pp. 6211–6218
  • Li, C., Lu, C. (2009) "Unconventional integration of the bla gene from plasmid pIT2 during ISlacZ/hah transposon mutagenesis in Pseudomonas aeruginosa PAO1," Current microbiology 58:5 pp. 472–477
  • Ni, N., Chou, H., Wang, J., Li, M., Lu, C., Tai, P.C., Wang, B. (2008) "Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi," Biochemical and biophysical research communications 369:2 pp. 590–594
  • Cheng, Y., Ni, N., Li, M., Chou, H., Lu, C., Tai, P.C., Wang, B. (2008) "MEDI 33-Synthesis and biological activity of antagonists of AI-2-mediated bacterial quorum sensing in Vibrio harveyi," 235:
  • Li, M., Ni, N., Chou, H., Lu, C., Tai, P.C., Wang, B. (2008) "Structure-Based Discovery and Experimental Verification of Novel AI-2 Quorum Sensing Inhibitors against Vibrio harveyi," ChemMedChem 3:8 pp. 1242–1249
  • Chou, H.T., Kwon, D., Hegazy, M., Lu, C. (2008) "Transcriptome analysis of agmatine and putrescine catabolism in Pseudomonas aeruginosa PAO1," Journal of bacteriology 190:6 pp. 1966–1975
  • Yang, Z., Lu, C. (2007) "Characterization of an arginine: pyruvate transaminase in arginine catabolism of Pseudomonas aeruginosa PAO1," Journal of bacteriology 189:11 pp. 3954–3959
  • Liu, P., Ewis, H.E., Tai, P.C., Lu, C., Weber, I.T. (2007) "Crystal structure of the Geobacillus stearothermophilus carboxylesterase Est55 and its activation of prodrug CPT-11," Journal of molecular biology 367:1 pp. 212–223
  • Zhang, Y., Ballard, C.E., Zheng, S., Gao, X., Ko, K., Yang, H., Brandt, G., Lou, X., Tai, P.C., Lu, C., others, . (2007) "Design, synthesis, and evaluation of efflux substrate–metal chelator conjugates as potential antimicrobial agents," Bioorganic & medicinal chemistry letters 17:3 pp. 707–711
  • Yang, Z., Lu, C. (2007) "Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa," Journal of bacteriology 189:11 pp. 3945–3953
  • Kwon, D., Lu, C. (2007) "Polyamine effects on antibiotic susceptibility in bacteria," Antimicrobial agents and chemotherapy 51:6 pp. 2070–2077
  • Li, W., Lu, C. (2007) "Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa," Journal of bacteriology 189:15 pp. 5413–5420
  • Liu, P., Ewis, H., Huang, Y., Lu, C., Tai, P., Weber, I.T. (2007) "Structure of Bacillus subtilis superoxide dismutase," Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63:12 pp. 1003–1007
  • Lu, C. (2006) "Pathways and regulation of bacterial arginine metabolism and perspectives for obtaining arginine overproducing strains," Applied Microbiology and Biotechnology 70:3 pp. 261–272
  • Kwon, D.H., Lu, C. (2006) "Polyamines increase antibiotic susceptibility in Pseudomonas aeruginosa," Antimicrobial agents and chemotherapy 50:5 pp. 1623–1627
  • Kwon, D.H., Lu, C. (2006) "Polyamines induce resistance to cationic peptide, aminoglycoside, and quinolone antibiotics in Pseudomonas aeruginosa PAO1," Antimicrobial agents and chemotherapy 50:5 pp. 1615–1622

Presentations

  • System Microbiology: Exploration of Metabolic Pathways and Antibacterial Targets, 2016
  • Polyamine Effects on Antibiotics Susceptibility , 2015 - China
  • System Microbiology: Exploration of Metabolic Pathways and Antibacterial Targets, 2015
  • Genomic Approaches forResearch on Bacterial Physiology: from Metabolism to Antibiotic Susceptibility - Invited Presentation, 2014 - Singapore
  • Polyamine Effects on Antibiotics Susceptibility in Bacteria, 2014
  • Functional Genomics: Exploration for Metabolic Pathways ane Regulation in Bacteria - Invited Presentation, 2013
  • Genomic Approaches for Bacterial Physiology Research: from Metabolism to Antibiotic Susceptibility - Keynote speaker in the 16th Conference on Bacteriology, 2011 - Taiwan
  • Polyamine Effects in Bacteria: from Metabolism to Antibiotic Susceptibility, 2010 - Taiwan
  • Catabolic Pathways for Arginine/Polyamine Utilization and the Regulatory Mechanisms in Pseudomonas aeruginosa, 2009 - Taiwan
  • Functional Genomics of Arginine Metabolism in Pseudomonas aeruginosa, 2009 - Taiwan
  • Polyamine Effects in Bacteria: from Metabolism to Antibiotic Susceptibility, 2009 - Taiwan
  • Polyamine Effects in Bacteria: from Metabolism to Antibiotic Susceptibility, 2008 - Taiwan
  • Regulation of Arginine Metabolism in Pseudomonas aeruginosa, 2008
  • Basic Research on Bacteria: from Taipei to Atlanta, 2007 - Taiwan
  • Exploring Metabolic Diversity of Bacteria in the Post-Genomic Era: A Case Study of Arginine Network in Pseudomonas aeruginosa, 2005 - Taipei, Taiwan
  • Identification of a two-component system as the second arginine-responsive regulators in Pseudomonas aeruginosa by transcriptome analysis - International Arginine/Pyrimidine Conference, 2004 - Marburg, Germany
  • Transcriptome and Computation Analysis of Arginine Metabolism in Pseudomonas aeruginosa: With and Without the Arginine Regulatory Protein, 2004
  • From Bacterial Physiology to Transcriptome Analysis, 2003
  • Development and Application of Functional Genomics, 2002 - Egypt
  • Post-genomic research of Pseudomonas aeruginosa: from GeneChip to arginine network - International Arginine/Pyrimidine Conference, 2002
  • Molecular cloning and characterization of S. paratyphi rma gene conferring multiple drug resistance in E. Coli - ICAAC 41th Annual Meeting, 2001
  • Arginine Metabolism in Pseudomonas aeruginosa - International Congress on Pseudomonas: Molecular Biology and Biotechnology, 2001
  • Control of glutamate metabolism by the arginine regulatory protein in Pseudomonas aeruginosa - International Arginine/Pyrimidine Conference, 2000
  • Mechanisms of ArgR-dependent promoter activation in Pseudomonas aeruginosa and enteric bacteria - International Arginine/Pyrimidine Conference, 2000

Contracts, Fellowships, Grants and Sponsored Research

  • NSF 0950217, "D-Amino Acid Metabolism in Pseudomonas aeruginosa" (2010), Grant -
    Lu, C. (Principal)