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Thomas Shea

Thomas B. Shea
Professor Thomas B. SheaProfessor, Director
  • CollegeCollege of Sciences
  • DepartmentBiological Science
  • Phone(978) 934-2881
  • Emailthomas_shea@uml.edu

Research Interests

Cell Biology

In my laboratory researchers are examining the roles played by axonal cytoskeletal proteins in nervous system development, and in the etiology of Alzheimer's and other related neurodegenerative diseases. For these studies we use neurons that are maintained in cell culture as well as genetically-modified strains of mice that are at increased risk for developing neurodegenerative conditions analogous to those observed in humans. Our studies indicate that Alzheimer's disease can arise from a combination of genetics, poor diet, and environmental stress, under conditions where no single one of these factors would induce the disease. My research center collaborates with a number of other nationally and internationally recognized laboratories. I am happy to discuss research opportunities in my laboratory with motivated undergraduate and graduate students.

Education

  • Ph D: Biology, (1983), Northeastern University, Boston - Boston, MA
  • MS: Biology, (1979), University of Massachusetts, Boston - Boston, MA
  • BA: Biology, (1974), University of Massachusetts, Boston - Boston, MA

Awards and Honors

  • Departmental Teaching Award (2010)
  • Honorary Chair of the annual "Memory Walk," (2006) - Alzheimer's Association, Lowell, MA
  • Excellence in Research Award (1991) - Umass-Lowell, Lowell, MA
  • Joseph. P. Healy Foundation (1991)
  • William F. Milton Fund Award (1991)
  • Charles A. King Trust Fellowship (1987)
  • Sigma Xi, elected to membership (1981)
  • Phi Sigma Society for Biological Research, elected President (Beta Nu Chapter) (1980)
  • Phi Sigma Society for Biological Research, elected to membership (1979) - Phi Sigma Society

Publications

  • Therrien, M., Vohnoutka, R., Boumil, E., Guaraldi, M., Lee, S., Shea, T.B. (2016) "Insufficient developmental excitatory neuronal activity fails to foster establishment of normal levels of inhibitory neuronal activity.," International Journal Of Developmental Neuroscience: The Official Journal Of The International Society For Developmental Neuroscience 55: pp. 66 - 71
  • Remington, R., Bechtel, C., Larsen, D., Samar, A., Page, R., Morrell, C., Shea, T.B. (2016) "Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study.," Journal Of Alzheimer’s Disease: JAD 51:4 pp. 991 - 995
  • Remington, R., Bechtel, C., Larsen, D., Samar, A., Doshanjh, L., Fishman, P., Luo, Y., Smyers, K., Page, R., Morrell, C., Shea, T.B. (2015) "A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimers Disease," Journal of Alzheimer’s Disease 45:2 pp. 395-405
  • Lee, S., Sohal, I.S., Therrien, M.A., Pal, A.K., Bello, D., Shea, T.B. (2015) "Additive Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Oligomerized Amyloid-ß and Airborne Nanoparticles Generated during Photocopying," Journal of Alzheimer’s disease 47:1 pp. 49-54
  • Shultz, A., Lee, S., Shea, T.B., Yanco, H. (2015) "Biological and simulated neuronal networks show similar competence on a visual tracking task," pp. 261–266
  • Bechtel, C., Remington, R., Barton, B., Barasauskas, C., Shea, T.B. (2015) "Cognitive testing for dementia is adversely affected by administration in a foreign location," BMC research notes 8: pp. 66
  • Doulames, V.M., Vilcans, M., Lee, S., Shea, T.B. (2015) "Social interaction attenuates the extent of secondary neuronal damage following closed head injury in mice," Frontiers in behavioral neuroscience 9: pp. 275
  • Shea, T.B., Remington, R. (2015) "Nutritional supplementation for Alzheimer’s disease?," Current opinion in psychiatry 28:2 pp. 141-147
  • Taddeo, M., Lee, S., Shea, T.B. (2014) "Synergistic inhibition of synaptic signaling in cortical cultures by subcytotoxic levels of oligomerized Amyloid beta and iron: allevation by zinc," Journal of Alzheimer's Disease 41: pp. 365-369
  • Lee, S., Pant, H., Shea, T. (2014) "Divergent and convergent roles for kinases and phosphatases in neurofilament dynamics," Journal of Cell Science 127:18 pp. 4064-4077
  • Lee, S., Zemianek, J.M., Shultz, A., Vo, A., Maron, B.Y., Therrien, M., Courtright, C., Guaraldi, M., Yanco, H., Shea, T.B. (2014) "Synaptic signal streams generated by ex vivo neuronal networks contain non-random, complex patterns.," International Journal of Developmental Neuroscience : the official journal of the International Society for Developmental Neuroscience 38: pp. 184-194
  • Shultz, A., Lee, S., Shea, T.B., Yanco, H. (2014) "Control of a robot arm with artificial and biological neural networks," AAAI Workshop on Artificial Intelligence and Robotics
  • Doulames, V., Lee, S., Shea, T. (2014) "Environmental Enrichment and Social Interaction Improve Cognitive Function in Normal Adult Mice," International Journal of Neuroscience 124: pp. 369-376
  • Shea, T., Rogers, E. (2014) "Lifetime requirement of the methionine cycle for neuronal development and maintenance," Current Opinion in Psychiatry 27: pp. 138-142
  • Zemianek, J., Lee, S., Shea, T. (2013) "Acceleration of myofiber formation in culture by a digitized synaptic signal," Tissue Engineering - Part A 19:23-24 pp. 2693-2702
  • Zemianek, J., Lee, S., Guaraldi, M., Shea, T. (2013) "Critical role for inhibitory neurons in modulation of synaptic signaling in ex vivo neuronal networks," International Journal of Developmental Neuroscience 31:5 pp. 308-310
  • Zemianek, J.M., Shultz, A.M., Lee, S., Guaraldi, M., Yanco, H.A., Shea, T.B. (2013) "Transient epileptiform signaling during neuronal network development: regulation by external stimulation and bimodal GABAergic activity," International Journal of Developmental Neuroscience 31:2 pp. 131-137
  • Lee, S., Zemianek, J., Shea, T. (2013) "Rapid, reversible impairment of synaptic signaling in cultured cortical neurons by exogenously-applied amyloid-ß," Journal of Alzheimer’s Disease 35:2 pp. 395-402
  • Lee, S., Shea, T.B. (2013) "Regulation of tau proteolysis by phosphatases," Brain research 1495: pp. 30-36
  • Zemianek, J.M., Lee, S., Guaraldi, M., Shea, T.B. (2012) "Accelerated establishment of mature signaling patterns following stimulation of developing neuronal networks: "learning" versus "plasticity"," International Journal of Developmental Neuroscience
  • Lee, S., Shea, T.B. (2012) "Caspase-mediated truncation of tau Potentiates aggregation," International Journal of Alzheimer's Disease pp. 731063
  • Lee, S., Lemere, C.A., Frost, J.L., Shea, T.B. (2012) "Dietary Supplementation with S-Adenosyl Methionine Delayed Amyloid-beta and Tau Pathology in 3xTg-AD Mice," Journal of Alzheimers Disease 28:2
  • Lee, S., Doulames, V., Donnelly, M., Levasseaur, J., Shea, T.B. (2012) "Environmental enrichment can prevent cognitive decline induced by dietary oxidative challenge," Journal of Alzheimer's Disease 28:3 pp. 497-501
  • Sunil, N., Lee, S., Shea, T.B. (2012) "Interference with kinesin-based anterograde neurofilament axonal transport increases neurofilament-neurofilament bundling," Cytoskeleton 69:6 pp. 371-379
  • Shea, T.B., Rogers, E., Remington, R. (2012) "Nutrition and Dementia: Are we Asking the Right Questions?," Journal of Alzheimers Disease 30:1
  • Zemianek, J.M., Serra, M., Guaraldi, M., Shea, T.B. (2012) "Stimulation with a low-amplitude, digitized synaptic signal to invoke robust activity within neuronal networks on multielectrode arrays," BioTechniques 52:3 pp. 177-182
  • Shea, T.B., Lee, S. (2012) "The discontinuous nature of neurofilament transport accommodates both establishment and repair of the axonal neurofilament array," Cytoskeleton (Hoboken, N.J.)
  • Lee, S., Sunil, N., Shea, T.B. (2011) "C-terminal neurofilament phosphorylation fosters neurofilament-neurofilament associations that compete with axonal transport," Cytoskeleton 68:1 pp. 8-17
  • Runge, M.S., Greganti, M.A., Adimora, A.A., Alattar, M., Aris, R.M., Bae-Jump, V.L., Baggstrom, M.Q., Barritt, A.S., Bassim, M.K., Bates, T., Beaven, A.W., Berger, R.G., Berkowitz, L.R., Bernard, S.A., Blau, W.S., Boggess, J.F., Bowman, M.C., Brecher, M.E., Bromberg, P.A., Brown, S.A., Brown, V., Bryson, P.C., Buckmire, R.A., Bullitt, E., Burkhart, C., Busby-Whitehead, M.J., Buse, J.B., Bynum, D.L., Carey, L.A., Carey, T.S., Carson III, C.C., Chang, P.P., Chaudhary, S., Clemmons, D.R., Coghill, J.M., Colindres, R.E., Connolly, A., Copeland, B.J., Correll, T., Denu-Ciocca, C.J., Devetski, T.S., DeWalt, D.A., Diaz, L.A., Donohue, J.F., Dooley, M.A., Dostou, J.M., Drossman, D.A., Dupree, C.S., Eapen, R.J., Ebert Jr, C.S., Erdem, N.F., Eron, J.J., Falk, R.J., Farmer-Boatwright, M.K., Fasy, E.A., Finkel, A.G., Finn, W.F., Fitzgerald, D.P., Ford, C.A., Forneris, C.A., Fowler, A.M., Fowler, W.C., Fowler, W.C., Fried, M.W., Gabriel, D.A., Galvin, S., Gangarosa, L.M., Garbutt, J.C., Gay, C., Gaylord, S.A., Gettes, L.S., Ghio, A.J., Gilmore, J.H., Godley, P.A., Goldberg, L.R., Goldberg, R.M., Goldenberg, M.N., Goldstein, B.P., Greenwood, R.S., Grimm, I.S., Grossman, S.H., Gwyther, R.E., Haggerty Jr, J.J., Harris, R.P., Heizer, W.D., Henderson, A.G., Henke, D.C., Hill, M.A., Hinderliter, A.L., Hinn, A.R., Hladik, G.A., Hoffman, H.M., Hosseinipour, M.C., Howard Jr, J.F., Huang, D.Y., Huang, X., Hutto, B.R., Isaacs, K.L., Israel, B.F., Ivester, T.S., Jacobe, H.T., Jacobson, P.L., Jantac, L., Jawanda, J.S., Johnson, S.M., Jonas, B.L., Jordan, J.M., Juliano, J.J., Kahn, K.A., Kaplan, A.H., Key, N.S., Kim, W.Y., Kizer, J.S., Klein, C.M., Klemmer, P.J., K?lln, K., Koruda, M.J., Kurz, J.E., LaCour, J., Ladha, A.M., Leight, W.D., Leone, P.A., Lindsey, B.A., Madanick, R.D., Mandelkehr, L.K., Mann, J.D., Markovic-Plese, S., Marshall, A.F., Mattern, W.D., Mayer, C.M., Meredith, T.A., Miller, W.C., Mitchell, B.S., Moll, S., Morgan, D.R., Morrell, D.S., Mu?oz, M.C., Nachman, P.H., Nelson, K.C., Nester, C.M., Nicholas, L.M., Ohman, E.M., O'Neil, B.H., Ontjes, D.A., Orlowski, R.Z., Parsons, D.J., Patel, D.D., Patterson, C., Patterson, K.B., Peppercorn, A., Pillsbury III, H.C., Rathmell, W.K., Reuland, D.S., Ringel, Y., Rivera, M.P., Rosebrock, C.N., Rosenberg, P., Roubey, R.A., Rubenstein, D.S., Runge, S.R., Russo, M., Rutala, W.A., Sanders Jr, W.E., Sanoff, H.K., Sanoff, S.L., Scarlett, Y.V., Schwarz, E.J., Senior, B.A., Serody, J.S., Shaheen, N.J., Shea, T.B., Sheahan, R.G., Shockley, W.W., Shrestha, R., Sickbert-Bennett, E.E., Sickel, M.J., Sikich, L., Simpson Jr, R.J., Smith Jr, S.C., Socinski, M.A., Sparling, P.F., Stinchcombe, T.E., Stouffer, G.A., Tarrant, T.K., Taylor, M., Thomas, M.J., Thomas, N.E., Thorpe Jr, J.M., Tilley, S.L., Ting, J.P., Tomsick, R.S., van der Horst, C.M., Vaughn, B.V., Vick, P.G., Vissers, R.J., Voorhees, P.M., Wang, T.Y., Watson, L.C., Weber, D.J., Wehbie, R.S., Weissler, M.C., Wells, E.C., Whang, Y.E., Willis IV, P.W., Winfield, J.B., Winzelberg, G.S., Wohl, D.A., Wong, L.P., Wu, D.N., Zacks, S. (2011) "Contributeurs," pp. 0-0
  • Lee, S., Sunil, N., Tejada, J.M., Shea, T.B. (2011) "Differential roles of kinesin and dynein in translocation of neurofilaments into axonal neurites," Journal of cell science 124:7 pp. 1022-1031
  • Remington, R., Shea, T.B., Bechtel, C.F., Lortie, J.J., Hoffmann, H., Dosanjh, L., Fishman, P., Samar, A. (2011) "Efficacy of a Nutriceutical Formulation on Cognitive Performance in Mci and Ad," Gerontologist 51:
  • Shea, T.B., Lee, S. (2011) "Neurofilament phosphorylation regulates axonal transport by an indirect mechanism: A merging of opposing hypotheses," Cytoskeleton 68:11 pp. 589-595
  • Lee, S., Hall, G.F., Shea, T.B. (2011) "Potentiation of tau aggregation by cdk5 and GSK3," Journal of Alzheimer's Disease 26:2 pp. 355-364
  • Shea, T.B., Johnson, J., Westervelt, P., Farag, S., McCarty, J., Bashey, A., Isola, L., Baxter-Lowe, L., Kelly, M., Owzar, K., Linker, C. (2011) "Reduced-Intensity Allogeneic Transplantation Provides High Event-Free and Overall Survival in Patients with Advanced Indolent B Cell Malignancies: CALGB 109901," Biology of Blood and Marrow Transplantation 17:9 pp. 1395-1403
  • Chan, A., Ortiz, D., Rogers, E., Shea, T.B. (2011) "Supplementation with apple juice can compensate for folate deficiency in a mouse model deficient in methylene tetra hydrofoate reductase activity," Journal of Nutrition, Health and Aging 15:3 pp. 221-225
  • Lortie, J.J., Remington, R., Shea, T.B., Hoffmann, H. (2011) "The Wais Digit Span Test: a Sensitive Indicator of Cognitive Decline in Mild Cognitive Impairment," Gerontologist 51:
  • Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., Shea, T.B. (2010) "A Vitamin/nutriceutical formulation improves Memory and cognitive performance in community-dwelling adults without dementia," Journal of Nutrition, Health and Aging 14:3 pp. 224-230
  • Kushkuley, J., Metkar, S., Chan, W.K., Lee, S., Shea, T.B. (2010) "Aluminum induces neurofilament aggregation by stabilizing cross-bridging of phosphorylated c-terminal sidearms," Brain research 1322: pp. 118-123
  • Chan, A., Shea, T.B. (2010) "Apolipoprotein E3 as a Risk Factor for Alzheimer's Disease Under Conditions of Nutritional Imbalance," Journal of Alzheimers Disease 21:1
  • Remington, R., Chan, A., Lepore, A., Kotlya, E., Shea, T.B. (2010) "Apple juice improved behavioral but not cognitive symptoms in moderate-to-late stage Alzheimer's disease in an open-label pilot study," American Journal of Alzheimer's Disease and Other Dementias 25:4 pp. 367-371
  • Suchy, J., Lee, S., Ahmed, A., Shea, T.B. (2010) "Dietary supplementation with S-adenosyl methionine delays the onset of motor neuron pathology in a murine model of amyotrophic lateral sclerosis," NeuroMolecular Medicine 12:1 pp. 86-97
  • Serra, M., Guaraldi, M., Shea, T.B. (2010) "Inhibitory neurons modulate spontaneous signaling in cultured cortical neurons: Density-dependent regulation of excitatory neuronal signaling," Physical Biology 7:2
  • Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., Shea, T.B. (2009) "A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia," Journal of Nutrition, Health and Aging pp. 1-7
  • Serra, M., Shea, T.B. (2009) "Apple juice stimulates organized synaptic activity in cultured cortical neurons," Current Topics in Nutraceutical Research 7:2 pp. 93-96
  • Kifle, L., Ortiz, D., Shea, T.B. (2009) "Deprivation of folate and B12 increases neurodegeneration beyond that accompanying deprivation of either vitamin alone," Journal of Alzheimer's Disease 16:3 pp. 533-540
  • Chan, A., Rogers, E., Shea, T.B. (2009) "Dietary deficiency in folate and vitamin e under conditions of oxidative stress increases phospho-tau levels: Potentiation by ApoE4 and alleviation by S-adenosylmethionine," Journal of Alzheimer's Disease 17:3 pp. 483-487
  • Suchy, J., Chan, A., Shea, T.B. (2009) "Dietary supplementation with a combination of -lipoic acid, acetyl-l-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance," Nutrition Research 29:1 pp. 70-74
  • Chan, A., Shea, T.B. (2009) "Dietary supplementation with apple juice decreases endogenous amyloid- levels in murine brain," Journal of Alzheimer's Disease 16:1 pp. 167-171
  • Chan, A., Paskavitz, J., Remington, R., Rasmussen, S., Shea, T.B. (2009) "Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: A 1-year, open-label pilot study with an 16-month caregiver extension," American Journal of Alzheimer's Disease and Other Dementias 23:6 pp. 571-585
  • Remington, R., Chan, A., Paskavitz, J., Shea, T.B. (2009) "Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage alzheimer's disease: A placebo-controlled pilot study," American Journal of Alzheimer's Disease and Other Dementias 24:1 pp. 27-33
  • Kushkuley, J., Chan, W.K., Lee, S., Eyer, J., Leterrier, J.F., Letournel, F., Shea, T.B. (2009) "Neurofilament cross-bridging competes with kinesin-dependent association of neurofilaments with microtubules," Journal of cell science 122:19 pp. 3579-3586
  • Shea, T.B., Lee, S., Kushkuley, J., Dubey, M., Chan, W.K. (2009) "Neurofilament dynamics: A tug of war by microtubule motors," Future Neurology 4:3 pp. 351-362
  • Remington, R., Chan, A., Tchantchou, F., Ortiz, D., Shea, T.B. (2009) "Neuroprotective effects of apples on cognition and Alzheimer's disease," Agro Food Industry Hi-Tech 20:6
  • Ruth, R., Amy, C., Flaubert, T., Daniela, O., Shea, T.B. (2009) "Neuroprotective effects of apples on cognition and Alzheimer's disease," Agro Food Industry Hi-Tech 20:6 pp. 32-34
  • Serra, M., Chan, A., Dubey, M., Shea, T.B. (2008) "A low-cost interface for multi-electrode array data acquisition systems," BioTechniques 45:4 pp. 451-456
  • Tagne, J., Kakumanu, S., Ortiz, D., Shea, T.B., Nicolosi, R.J. (2008) "A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line," Molecular Pharmaceutics 5:2
  • Tchantchou, F., Shea, T.B. (2008) "Chapter 3 Folate Deprivation, the Methionine Cycle, and Alzheimer's Disease," Volume 79: pp. 83-97
  • Chan, A., Tchantchou, F., Graves, V., Rozen, R., Shea, T.B. (2008) "Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: Critical role of S-adenosyl methionine," Journal of Nutrition, Health and Aging 12:4 pp. 252-261
  • Perry, S., Levasseur, J., Chan, A., Shea, T.B. (2008) "Dietary supplementation with S-adenosyl methionine was associated with protracted reduction of seizures in a line of transgenic mice," Comparative medicine 58:6 pp. 604-606
  • Chan, A., Shea, T.B. (2008) "Effects of dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4 (Neuromolecular Medicine DOI: 10.1007/s12017-007-8005-y)," NeuroMolecular Medicine 10:1 pp. 46
  • Chan, A., Paskavitz, J., Remington, R., Rasmussen, S., Shea, T.B. (2008) "Efficacy of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease: A 1-year, Open-label Pilot Study With a 16-Month Caregiver Extension," American Journal of Alzheimers Disease and Other Dementias 23:6
  • Serra, M., Chan, A., Dubey, M., Gilman, V., Shea, T.B. (2008) "Erratum: A low-cost interface for multi-electrode array data acquisition systems (BioTechniques vol. 45 (451-456) 10.2144/000112911)," BioTechniques 45:6 pp. 607
  • Serra, M., Chan, A., Dubey, M., Gilman, V., Shea, T.B. (2008) "Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: Acute differential impact on normal and apolipoprotein- deficient mice," Physical Biology 5:4
  • Chan, A.Y., Alsaraby, A., Shea, T.B. (2008) "Folate deprivation increases tau phosphorylation by homocysteine-induced calcium influx and by inhibition of phosphatase activity: Alleviation by S-adenosyl methionine," Brain research 1199: pp. 133-137
  • Tchantchou, F., Shea, T.B. (2008) "FOLATE DEPRIVATION, THE METHIONINE CYCLE, AND ALZHEIMER's DISEASE," Folic Acid and Folates 79:
  • Shea, T.B., Chan, A., Remington, R., Lepore, A., Goodrow, E., Paskavitz, J. (2008) "P4-345: A vitamin/nutriceutical formulation that delays cognitive decline and improves behavioral symptoms in Alzheimer's disease," Alzheimer's & Dementia 4:4, Supplement
  • Shea, T.B., Chan, W.K. (2008) "Regulation of neurofilament dynamics by phosphorylation," European Journal of Neuroscience 27:8 pp. 1893-1901
  • Shea, T.B., Chan, A. (2008) "S-adenosyl methionine: A natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer's disease," Journal of Alzheimer's Disease 13:1 pp. 67-70
  • Tchantchou, F., Graves, M., Falcone, D., Shea, T.B. (2008) "S-Adenosylmethionine mediates glutathione efficacy by increasing glutathione S-transferase activity: Implications for S-adenosyl methionine as a neuroprotective dietary supplement," Journal of Alzheimer's Disease 14:3 pp. 323-328
  • Dubey, M., Chaudhury, P., Kabiru, H., Shea, T.B. (2008) "Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau-mediated neurite instability," Cell motility and the cytoskeleton 65:2 pp. 89-99
  • Chan, A., Remington, R., Paskavitz, J., Shea, T.B. (2008) "The clock-drawing test: Time for a change?," American Journal of Alzheimer's Disease and Other Dementias 23:4 pp. 377-381
  • Lee, S., Chu, B., Yao, J., Shea, T.B., Hall, G.F. (2008) "The glutamate-rich region of the larger lamprey neurofilament sidearm is essential for proper neurofilament architecture," Brain research 1231: pp. 1-5
  • Kim, F., Kotyla, T., Wilson, T., Kifle, L., Panagiotou, T., Gruverman, I., Tagne, J., Shea, T.B., Nicolosi, R. (2007) "A nanoemulsion of an anti-oxidant synergy formulation reduces tumor growth rate in neuroblastoma-bearing nude mice," Journal of neuropathology and experimental neurology 66:5
  • Kuo, F., Kotyla, T., Wilson, T., Kifle, L., Panagiotou, T., Gruverman, I., Tagne, J., Shea, T.B., Nicolosi, R. (2007) "A nanoemulsion of an anti-oxidant synergy formulation reduces tumor growth rate in neuroblastoma-bearing nude mice.," Faseb Journal 21:5
  • DeFuria, J., Shea, T.B. (2007) "Arsenic inhibits neurofilament transport and induces perikaryal accumulation of phosphorylated neurofilaments: Roles of JNK and GSK-3," Brain research 1181:1 pp. 74-82
  • Lepore, A., Goodrow, E., Chan, A., Shea, T.B. (2007) "Cognitive performance in normal seniors is enhanced by a nutraceutical formulation," Faseb Journal 21:6
  • Shea, T.B. (2007) "Effects of dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4," NeuroMolecular Medicine 9:3 pp. 264-269
  • Chan, A., Shea, T.B. (2007) "Effects of dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4.," Neuromolecular medicine 9:3
  • Chan, A., Shea, T.B. (2007) "Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: Potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine," Journal of neurochemistry 102:3 pp. 753-760
  • Motil, J., Dubey, M., Chan, W.K., Shea, T.B. (2007) "Inhibition of dynein but not kinesin induces aberrant focal accumulation of neurofilaments within axonal neurites," Brain research 1164:1 pp. 125-131
  • Chan, A., Paskavitz, J., Shea, T.B. (2007) "P-011: A novel vitamin/nutraceutical formulation that delays cognitive decline and improves mood in early-stage Alzheimer s disease," Alzheimer's & Dementia 3:3, Supplement
  • Dubey, M., Shea, T.B. (2007) "Potentiation of arsenic neurotoxicity by folate deprivation: Protective role of S-adenosyl methionine," Nutritional Neuroscience 10:5-6 pp. 199-204
  • Sihag, R.K., Inagaki, M., Yamaguchi, T., Shea, T.B., Pant, H.C. (2007) "Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments," Experimental cell research 313:10 pp. 2098-2109
  • Pandey, M.K., Tyagi, R., Parmar, V.S., Tucci, V.B., Kumar, J., Shea, T.B., Watterson, A.C. (2007) "Synthesis and characterization of nanocarrier containing antioxidant 4-methylcoumarin," Abstracts of Papers of the American Chemical Society 234:
  • Shea, T.B., Beaty, W.J. (2007) "Traffic jams: Dynamic models for neurofilament accumulation in motor neuron disease," Traffic 8:4 pp. 445-447
  • Chan, A., Graves, V., Shea, T.B. (2006) "Apple juice concentrate maintains acetylcholine levels following dietary compromise," Journal of Alzheimer's Disease 9:3 pp. 287-291
  • Chan, A., Shea, T.B. (2006) "Dietary and genetically-induced oxidative stress alter tau phosphorylation: Influence of folate and apolipoprotein E deficiency," Journal of Alzheimer's Disease 9:4 pp. 399-405
  • Shea, T.B., Morris, M.C., Evans, D.A., Schneider, J.A., Tangney, C.C., Bienias, J.L., Aggarwal, N.T. (2006) "Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease," Journal of Alzheimer's Disease 9:4 pp. 435-443
  • DeFuria, J., Chen, P., Shea, T.B. (2006) "Divergent effects of the MEKK-1/JNK pathway on NB2a/d1 differentiation: Some activity is required for outgrowth and stabilization of neurites but overactivation inhibits both phenomena," Brain research 1123:1 pp. 20-26
  • Motil, J., Chan, W.K., Dubey, M., Chaudhury, P., Pimenta, A., Chylinski, T.M., Ortiz, D.T., Shea, T.B. (2006) "Dynein mediates retrograde neurofilament transport within axons and anterograde delivery of NFs from perikarya into axons: Regulation by multiple phosphorylation events," Cell motility and the cytoskeleton 63:5 pp. 266-286
  • Tchantchou, F., Graves, M., Shea, T.B. (2006) "Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: Modulation by apolipoprotein E-deficiency," Nutritional Neuroscience 9:1-2 pp. 17-24
  • Shea, T.B. (2006) "Folate, the methionine cycle, and Alzheimer's disease," Journal of Alzheimer's Disease 9:4 pp. 359-360
  • Shea, T.B., Chan, A. (2006) "Food for thought: Dietary influence on acetylcholine," Journal of Alzheimer's Disease 10:4 pp. 363-364
  • Mbadugha, B.N., Seo, J., Ji, H., Mart?sek, P., Roman, L.J., Shea, T.B., Li, H., Poulos, T.L., Silverman, R.B. (2006) "Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase," Bioorganic & medicinal chemistry 14:11 pp. 3681-3690
  • Chan, A.Y., Graves, V., Rozen, R., Shea, T.B. (2006) "P4-357: Dietary and genetic compromise in folate availability reduces acetylcholine and cognitive performance: Critical role of S-adenosyl methionine," Alzheimer's & Dementia 2:3, Supplement
  • Tchantchou, F., Graves, M., Ortiz, D., Chan, A., Rogers, E., Shea, T.B. (2006) "S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease," Journal of Nutrition, Health and Aging 10:6 pp. 541-544
  • Shea, T.B., Lombardo, N.B. (2006) "Selected Abstracts From the "Wellness For Persons With Dementia" Symposium," Journal of Alzheimer's Disease 9:4 pp. 445-448
  • Chan, A., Shea, T.B. (2006) "Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress," Journal of Alzheimer's Disease 10:4 pp. 353-358
  • Shea, T.B., Cavallaro, R.A., Fuso, A., D'Anselmi, F., Seminara, L., Scarpa, S. (2006) "The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis," Journal of Alzheimer's Disease 9:4 pp. 415-419
  • Tchantchou, F., Chan, A., Kifle, L., Ortiz, D., Shea, T.B. (2005) "Apple juice concentrate prevents oxidative damage and impaired maze performance in aged mice," Journal of Alzheimer's Disease 8:3 pp. 283-287
  • Moran, C.M., Donnelly, M., Ortiz, D., Pant, H.C., Mandelkow, E.M., Shea, T.B. (2005) "Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity," Molecular Brain Research 134:2 pp. 338-344
  • Dhitavat, S., Ortiz, D., Rogers, E., Rivera, E., Shea, T.B. (2005) "Folate, vitamin E, and acetyl-L-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta," Brain research 1061:2 pp. 114-117
  • Watterson, A.C., Parmar, V.S., Kumar, R., Sharma, S.K., Shakil, N.A., Tyagi, R., Sharma, S.K., Samuelson, L.A., Kumar, J., Nicolosi, R., Shea, T.B. (2005) "Indo-U.S. collaborative studies on biocatalytic generation of novel molecular architectures," Pure and Applied Chemistry 77:1 pp. 201-208
  • Dawn-Linsley, M., Ekinci, F.J., Ortiz, D., Rogers, E., Shea, T.B. (2005) "Monitoring thiobarbituric acid-reactive substances (TBARs) as an assay for oxidative damage in neuronal cultures and central nervous system," Journal of neuroscience methods 141:2 pp. 219-222
  • Tchantchou, F., Graves, M., Rogers, E., Ortiz, D., Shea, T.B. (2005) "N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency," Journal of Alzheimers Disease 7:2
  • Shea, T.B., Ortiz, D., Nicolosi, R.J., Kumar, R., Watterson, A.C. (2005) "Nanosphere-mediated delivery of vitamin E increases its efficacy against oxidative stress resulting from exposure to amyloid beta," Journal of Alzheimer's Disease 7:4 pp. 297-301
  • Chan, W.K., Yabe, J.T., Pimenta, A.F., Ortiz, D., Shea, T.B. (2005) "Neurofilaments can undergo axonal transport and cytoskeletal incorporation in a discontinuous manner," Cell motility and the cytoskeleton 62:3 pp. 166-179
  • Jung, C., Lee, S., Ortiz, D., Zhu, Q., Julien, J.P., Shea, T.B. (2005) "The high and middle molecular weight neurofilament subunits regulate the association of neurofilaments with kinesin: Inhibition by phosphorylation of the high molecular weight subunit," Molecular Brain Research 141:2 pp. 151-155
  • Rogers, E.J., Milhalik, S., Ortiz, D., Shea, T.B. (2004) "Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice," Journal of Nutrition, Health and Aging 8:2 pp. 92-97
  • Ortiz, D., Shea, T.B. (2004) "Apple juice prevents oxidative stress induced by amyloid-beta in culture," Journal of Alzheimer's Disease 6:1 pp. 27-30
  • Shea, T.B., Yabe, J.T., Ortiz, D., Pimenta, A., Loomis, P., Goldman, R.D., Amin, N., Pant, H.C. (2004) "Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons," Journal of cell science 117:6 pp. 933-941
  • Shea, T.B., Zheng, Y.L., Ortiz, D., Pant, H.C. (2004) "Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress," Journal of neuroscience research 76:6 pp. 795-800
  • Tchantchou, F., Graves, M., Ortiz, D., Rogers, E., Shea, T.B. (2004) "Dietary supplementation with apple juice concentrate alleviates the compensatory increase in glutathione synthase transcription and activity that accompanies dietary- and genetically-induced oxidative stress," Journal of Nutrition, Health and Aging 8:6 pp. 492-496
  • Shea, T.B., Ortiz, D., Rogers, E. (2004) "Differential susceptibility of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation," Journal of Alzheimer's Disease 6:3 pp. 269-273
  • Tjiattas, L., Ortiz, D.O., Dhivant, S., Mitton, K., Rogers, E., Shea, T.B. (2004) "Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation," Aging Cell 3:2 pp. 71-76
  • Tchantchou, F., Graves, M., Ashline, D., Morin, A., Pimenta, A., Ortiz, D., Rogers, E., Shea, T.B. (2004) "Increased Transcription and Activity of Glutathione Synthase in Response to Deficiencies in Folate, Vitamin E, and Apolipoprotein E," Journal of neuroscience research 75:4 pp. 508-515
  • Tchantchou, F., Graves, M.V., Ortiz, D., Rogers, E., Shea, T.B. (2004) "Interaction of folate deficiency and apolipoprotein E gene dosage on cognitive impairment and oxidative damage to brain tissue: Compensatory regulation of methionine cycle genes," Neurobiology of aging 25:
  • Chan, W.K., Dickerson, A., Ortiz, D., Pimenta, A.F., Moran, C.M., Motil, J., Snyder, S.J., Malik, K., Pant, H.C., Shea, T.B. (2004) "Mitogen-activated protein kinase regulates neurofilament axonal transport," Journal of cell science 117:20 pp. 4629-4642
  • Jung, C., Chylinski, T.M., Pimenta, A., Ortiz, D., Shea, T.B. (2004) "Neurofilament transport is dependent on actin and myosin," Journal of Neuroscience 24:43 pp. 9486-9496
  • Tchantchou, F., Graves, M.V., Ortiz, D., Rogers, E., Shea, T.B. (2004) "P4-130 Interaction of folate deficiency and apolipoprotein E gene dosage on cognitive impairment and oxidative damage to brain tissue: compensatory regulation of methionine cycle genes," Neurobiology of aging 25, Supplement 2:
  • Dubey, M., Hoda, S., Chan, W.K., Pimenta, A., Ortiz, D.D., Shea, T.B. (2004) "Reexpression of vimentin in differentiated neuroblastoma cells enhances elongation of axonal neurites," Journal of neuroscience research 78:2 pp. 245-249
  • Shea, T.B., Ashline, D., Ortiz, D., Milhalik, S., Rogers, E. (2004) "The S-Adenosyl Homocysteine Hydrolase Inhibitor 3-Deaza-Adenosine Prevents Oxidative Damage and Cognitive Impairment Following Folate and Vitamin E Deprivation in a Murine Model of Age-Related, Oxidative Stress-Induced Neurodegeneration," NeuroMolecular Medicine 5:2 pp. 171-180
  • Shea, T.B., Ortiz, D. (2003) "17 -Estradiol alleviates synergistic oxidative stress resulting from folate deprivation and amyloid- treatment," Journal of Alzheimer's Disease 5:4 pp. 323-327
  • Hancock, A.L., Nakuci, E., Nicolosi, R.J., Shea, T.B. (2003) "An antioxidant formulation that induces differentiation of neuroblastoma in culture," Neuroscience Research Communications 33:1 pp. 73-76
  • Shea, T.B., Jung, C., Pant, H.C. (2003) "Does neurofilament phosphorylation regulate axonal transport?," Trends in neurosciences 26:8 pp. 397-400
  • Shea, T.B., Ekinci, F.J., Ortiz, D., Wilson, T.O., Nicolosi, R.J. (2003) "Efficacy of vitamin E, phosphatidyl choline and pyruvate on Abeta neurotoxicity in culture," Journal of Nutrition, Health and Aging 7:4 pp. 252-255
  • Mattson, M.P., Shea, T.B. (2003) "Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders," Trends in neurosciences 26:3
  • Mihalick, S.M., Ortiz, D., Kumar, R., Rogers, E., Shea, T.B. (2003) "Folate and Vitamin E Deficiency Impair Cognitive Performance in Mice Subjected to Oxidative Stress: Differential Impact on Normal Mice and Mice Lacking Apolipoprotein E," NeuroMolecular Medicine 4:3 pp. 197-201
  • Ho, P.I., Ashline, D., Dhitavat, S., Ortiz, D., Collins, S.C., Shea, T.B., Rogers, E. (2003) "Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine," Neurobiology of disease 14:1 pp. 32-42
  • Chan, W.K., Yabe, J.T., Pimenta, A.F., Ortiz, D., Shea, T.B. (2003) "Growth cones contain a dynamic population of neurofilament subunits," Cell motility and the cytoskeleton 54:3 pp. 195-207
  • Ekinci, F.J., Ortiz, D., Shea, T.B. (2003) "Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel," Molecular Brain Research 117:2 pp. 145-151
  • Shea, T.B., Rogers, E., Ashline, D., Ortiz, D., Sheu, M.S. (2003) "Quantification of antioxidant activity in brain tissue homogenates using the 'total equivalent antioxidant capacity'," Journal of neuroscience methods 125:1-2 pp. 55-58
  • Yabe, J.T., Chan, W.K., Wang, F.S., Pimenta, A., Ortiz, D.D., Shea, T.B. (2003) "Regulation of the Transition From Vimentin to Neurofilaments During Neuronal Differentiation," Cell motility and the cytoskeleton 56:3 pp. 193-205
  • Dhitavat, S., Ortiz, D., Shea, T.B., Rivera, E.R. (2002) "Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: Roles of oxidative buffering and ATP levels," Neurochemical research 27:6 pp. 501-505
  • Shea, T.B., Rogers, E., Ashline, D., Ortiz, D., Sheu, M.S. (2002) "Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue," Free Radical Biology and Medicine 33:8 pp. 1115-1120
  • Dhitavat, S., Ortiz, D., Rivera, E., Shea, T.B. (2002) "Divergent and convergent oxidative damage following Abeta treatment in culture," Molecular biology of the cell 13:
  • Shea, T.B., Ekinci, F.J., Ortiz, D., Dawn-Linsley, M., Wilson, T.O., Nicolosi, R.J. (2002) "Efficacy of vitamin E, phosphatidyl choline, and pyruvate on buffering neuronal degeneration and oxidative stress in cultured cortical neurons and in central nervous tissue of apolipoprotein E-deficient mice," Free Radical Biology and Medicine 33:2 pp. 276-282
  • Shea, T.B., Rogers, E. (2002) "Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: Augmentation by vitamin E," Molecular Brain Research 108:1-2 pp. 1-6
  • Shea, T.B., Rogers, E., Auer, J., Berent, R., Eber, B., Seshadri, S., Wolf, P.A. (2002) "Homocysteine and dementia [1] (multiple letters)," New England Journal of Medicine 346:25 pp. 2007-2008
  • Ho, P.I., Ortiz, D., Rogers, E., Shea, T.B. (2002) "Multiple aspects of homocysteine neurotoxicity: Glutamate excitotoxicity, kinase hyperactivation and DNA damage," Journal of neuroscience research 70:5 pp. 694-702
  • Ho, R., Ortiz, D., Shea, T.B. (2001) "Amyloid- promotes calcium influx and neurodegeneration via stimulation of L voltage-sensitive calcium channels rather than NMDA channels in cultured neurons," Journal of Alzheimer's Disease 3:5 pp. 479-483
  • Dhitavat, S., Rivera, E.R., Rogers, E., Shea, T.B. (2001) "Differential efficacy of lipophilic and cytosolic antioxidants on generation of reactive oxygen species by amyloid-," Journal of Alzheimer's Disease 3:6 pp. 525-529
  • Ho, P., Ashline, D., Dhitavat, S., Collins, S., Rogers, E.J., Shea, T.B. (2001) "Folate deprivation induces neurodegeneration: Roles of oxidative stress and increased homocysteine," Molecular biology of the cell 12:
  • Chan, W.K., Chylinski, T.M., Yabe, J.T., Shea, T.B. (2001) "Growth cones contain a highly-dynamic population of neurofilament subunits," Molecular biology of the cell 12:
  • Ho, P.I., Collins, S.C., Dhitavat, S., Ortiz, D., Ashline, D., Rogers, E., Shea, T.B. (2001) "Homocysteine potentiates -amyloid neurotoxicity: Role of oxidative stress," Journal of neurochemistry 78:2 pp. 249-253
  • Chylinski, T.M., Shea, T.B. (2001) "Kinesin, dynein and myosin mediate neurofilament axonal transport," Molecular biology of the cell 12:
  • Shea, T.B., Flanagan, L.A. (2001) "Kinesin, dynein and neurofilament transport," Trends in neurosciences 24:11 pp. 644-648
  • Yabe, J.T., Chylinski, T., Wang, F.S., Pimenta, A., Kattar, S.D., Linsley, M.D., Chan, W.K., Shea, T.B. (2001) "Neurofilaments consist of distinct populations that can be distinguished by C-terminal phosphorylation, bundling, and axonal transport rate in growing axonal neurites," Journal of Neuroscience 21:7 pp. 2195-2205
  • Yabe, J.T., Wang, F.S., Chylinski, T., Katchmar, T., Shea, T.B. (2001) "Selective accumulation of the high molecular weight neurofilament subunit within the distal region of growing axonal neurites," Cell motility and the cytoskeleton 50:1 pp. 1-12
  • Dhitavat, S., Rivera, E., Shea, T.B. (2001) "The acetyl-CoA precursor, acetyl-L-carnitine, diminishes amyloid-beta neurotoxicity: Role of ATP and electron transport," Molecular biology of the cell 12:
  • Yabe, J.T., Chan, W.K., Chylinski, T.M., Lee, S., Pimenta, A.F., Shea, T.B. (2001) "The predominant form in which neurofilament subunits undergo axonal transport varies during axonal initiation, elongation, and maturation," Cell motility and the cytoskeleton 48:1 pp. 61-83
  • Ekinci, F.J., Linsley, M.D., Shea, T.B. (2000) "-Amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation," Molecular Brain Research 76:2 pp. 389-395
  • Ekinci, F.J., Shea, T.B. (2000) "-Amyloid-induced tau phosphorylation does not correlate with degeneration in cultured neurons," Journal of Alzheimer's Disease 2:1 pp. 7-15
  • Ma, D., Himes, B.T., Shea, T.B., Fischer, I. (2000) "Axonal transport of microtubule-associated protein 1B (MAP1B) in the sciatic nerve of adult rat: Distinct transport rates of different isoforms," Journal of Neuroscience 20:6 pp. 2112-2120
  • Ekinci, F.J., Linsley, M.D., Shea, T.B. (2000) "Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation.," Brain research.Molecular brain research 76:2
  • Jung, C., Yabe, J.T., Shea, T.B. (2000) "C-terminal phosphorylation of the high molecular weight neurofilament subunit correlates with decreased neurofilament axonal transport velocity," Brain research 856:1-2 pp. 12-19
  • Jung, C., Yabe, J.T., Lee, S., Shea, T.B. (2000) "Hypophosphorylated neurofilament subunits undergo axonal transport more rapidly than move extensively phosphorylated subunits in situ," Cell motility and the cytoskeleton 47:2
  • Shea, T.B. (2000) "Microtubule motors, phosphorylation and axonal transport of neurofilaments," Brain Cell Biology 29:11-12 pp. 873-887
  • Chan, W.K., Chylinski, T.M., Yabe, J.T., Pimenta, A.F., Shea, T.B. (2000) "Mitogen activated protein kinase influences neurofilament axonal transport," Molecular biology of the cell 11:
  • Shea, T.B. (2000) "Modulation of calpain-mediated protein kinase C activation within intact cells.," Methods in molecular biology (Clifton, N.J.) 144:
  • Chylinski, T., Yabe, J.T., Chan, W.K., Lee, S.M., Pimenta, A.F., Shea, T.B. (2000) "Neurofilaments can undergo axonal transport in multiple forms," Molecular biology of the cell 11:
  • Shea, T.B., Yabe, J. (2000) "Occam's razor slices through the mysteries of neurofilament axonal transport: Can it really be so simple?," Traffic 1:6 pp. 522-523
  • Yabe, J.T., Jung, C., Chan, W.K., Shea, T.B. (2000) "Phospho-dependent association of neurofilament proteins with kinesin in situ," Cell motility and the cytoskeleton 45:4 pp. 249-262
  • Ekinci, F.J., Shea, T.B. (2000) "Phosphorylation of tau alters its association with the plasma membrane," Cellular and molecular neurobiology 20:4 pp. 497-508
  • Jung, C., Yabe, J.T., Lee, S., Shea, T.B. (2000) "Stochastic simulation of processive and oscillatory sliding using a two-headed model for axonemal dynein," Cell motility and the cytoskeleton 47:2 pp. 108-119
  • Yabe, J.T., Chan, W.K., Chylinski, T.M., Lee, S., Pimenta, A.F., Shea, T.B. (2000) "The predominant form in which neurofilament subunits undergo axonal transport varies during axonal initiation, elongation, and maturation," Cell motility and the cytoskeleton 48:1 pp. 61-83
  • Ekinci, F.J., Malik, K.U., Shea, T.B. (1999) "Activation of the L voltage-sensitive calcium channel by mitogen- activated protein (MAP) kinase following exposure of neuronal cells to - amyloid. MAP kinase mediates -amyloid-induced neurodegeneration," Journal of Biological Chemistry 274:42 pp. 30322-30327
  • Ekinci, F.J., Linsley, M.D., Shea, T.B. (1999) "Beta-Amyloid-Induced Calcium Influx Induces Neurodegeneration in Culture by Oxidative Stress rather than Tau Phosphorylation," Molecular biology of the cell 10:
  • Shea, T.B., Ekinci, F.J. (1999) "Biphasic effect of calcium influx on tau phosphorylation: Involvement of calcium-dependent phosphatase and kinase activities," Journal of Alzheimer's Disease 1:6 pp. 353-360
  • Ekinci, F.J., Shea, T.B. (1999) "Free PKC catalytic subunits (PKM) phosphorylate tau via a pathway distinct from that utilized by intact PKC," Brain research 850:1-2 pp. 207-216
  • Ekinci, F.J., Shea, T.B. (1999) "Hyperactivation of mitogen-activated protein kinase increases phospho- tau immunoreactivity within human neuroblastoma: Additive and synergistic influence of alteration of additional kinase activities," Cellular and molecular neurobiology 19:2 pp. 249-260
  • Yabe, J.T., Pimenta, A., Shea, T.B. (1999) "Kinesin-mediated transport of neurofilament protein oligomers in growing axons," Journal of cell science 112:21 pp. 3799-3814
  • Shea, T.B., Beermann, M.L. (1999) "Neuronal intermediate filament protein -internexin facilitates axonal neurite elongation in neuroblastoma cells," Cell motility and the cytoskeleton 43:4 pp. 322-333
  • Shea, T.B., Yabe, J.T., Wang, F.S. (1999) "Non-uniform transport and distribution of neurofilament subunits in growing axonal neurites," Molecular biology of the cell 10:
  • Jung, C., Shea, T.B. (1999) "Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ," Cell motility and the cytoskeleton 42:3 pp. 230-240
  • Shea, T.B. (1999) "Selective stabilization of microtubules within the proximal region of developing axonal neurites," Brain research bulletin 48:3 pp. 255-261
  • Shea, T.B., Cressman, C.M. (1999) "The order of exposure of tau to signal transduction kinases alters the generation of 'AD-like' phosphoepitopes," Cellular and molecular neurobiology 19:2 pp. 223-233
  • Shea, T.B., Dergay, A.N., Ekinci, F.J. (1998) "-amyloid induced hyperphosphorylation of tau in human neuroblastoma cells involves MAP kinase," Neuroscience Research Communications 22:1 pp. 45-49
  • Shea, T.B., Dergay, A.N., Ekinci, F.J. (1998) "-Amyloid induced hyperphosphorylation of tau in human neuroblastoma cells involves MAP kinase," Neuroscience Research Communications 22:1 pp. 45-49
  • Shea, T.B., Cressman, C.M. (1998) "A 26-30 kDa developmentally-regulated tau isoform localized within nuclei of mitotic human neuroblastoma cells," International Journal of Developmental Neuroscience 16:1 pp. 41-48
  • Shea, T.B., Dergay, A.N., Ekinci, F.J. (1998) "Beta-Amyloid Induced Hyperphosphorylation of Tau in Human Neuroblastoma Cells Involves Map Kinase," Neuroscience Research Communications 22:1
  • Shea, T.B., Didier, M. (1998) "Biphasic effects of phosphatase inhibiton on accumulation of tau phospho-isoforms in cultured cerebellar neurons," Neuroscience Research Communications 22:1 pp. 39-44
  • Ekinci, F.J., Shea, T.B. (1998) "Calcium influx following beta-amyloid exposure is mediated by mitogen-activated protein (MAP) kinase.," Molecular biology of the cell 9:
  • Boyce, J.J., Shea, T.B. (1998) "Divergent influences of protein kinase C isoforms on intracellular levels of phosphorylated and non-phosphorylated tau immunoreactivity," Neuroscience Research Communications 22:1 pp. 51-57
  • Shea, T.B., Jung, C., Yabe, J., Ma, D., Fischer, I. (1998) "Extensive phosphorylation and axonal transport of triton-soluble neurofilament subunits.," Sub-cellular biochemistry 31: pp. 527-561
  • Surprenant, M.J., Shea, T.B. (1998) "Induction of morphological differentiation of neuroblastoma cells by a mitotic inhibitor: Neuritogenesis is a default pathway invoked by developmental withdrawal of neuroblasts from the mitotic cycle," Neuroscience Research Communications 22:1 pp. 59-62
  • Jung, C., Yabe, J., Wang, F.S., Shea, T.B. (1998) "Neurofilament subunits can undergo axonal transport without incorporation into triton-insoluble structures," Cell motility and the cytoskeleton 40:1 pp. 44-58
  • Yabe, J.T., Jung, C., Shea, T.B. (1998) "Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ: Involvement of the microtubule motor protein kinesin.," Molecular biology of the cell 9:
  • Tupper, C.L., Shea, T.B. (1998) "Transforming growth factor 2 can exert protection towards and exacerbation of -amyloid toxicity depending upon growth factor concentration and length of exposure," Neuroscience Research Communications 22:2 pp. 83-89
  • Shea, T.B., Prabhakar, S., Ekinci, F.J. (1997) "-amyloid and ionophore A23187 evoke tau hyperphosphorylation by distinct intracellular pathways: differential involvement of the calpain/protein kinase C system," Journal of neuroscience research 49:6 pp. 759-768
  • Pundreddy, S., Shea, T.B. (1997) "AD-like tau phosphorylation in human neuroblastoma cells following PKC hyperactivation is mediated by MAP kinase," Neuroscience Research Communications 21:3 pp. 173-177
  • Shea, T.B., Wheeler, E., Jung, C. (1997) "Aluminum inhibits neurofilament assembly, cytoskeletal incorporation, and axonal transport: Dynamic nature of aluminum-induced perikaryal neurofilament accumulations as revealed by subunit turnover," Molecular and Chemical Neuropathology 32:1-3 pp. 17-39
  • Jung, C., Wheeler, E., Dahl, D., Shea, T.B. (1997) "Axonally-transported neurofilament proteins exist in multiple solubility states in mouse optic pathway and NB2a/d1 cells," Journal of neurochemistry 69:
  • Shea, T.B., Prabhakar, S., Ekinci, F.J. (1997) "beta-amyloid and ionophore A23187 evoke Tau hyperphosphorylation by distinct intracellular pathways: Differential involvement of the calpain protein kinase C system," Journal of neuroscience research 49:6
  • Tupper, C., Pundreddy, S., Prabhakar, S., Chang, M., Shea, T.B. (1997) "beta-amyloid and ionophore-mediated calcium influx evoke tau hyperphosphorylation by distinct and common intracellular pathways: Differential involvement of the calpain protein kinase C system," Journal of neurochemistry 69:
  • Grynspan, F., Griffin, W.B., Mohan, P.S., Shea, T.B., Nixon, R.A. (1997) "Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: Comparison with the human brain calpain system," Journal of neuroscience research 48:3 pp. 181-191
  • Shea, T.B. (1997) "Creation of a ''virtual'' journal club using a threaded Internet newsgroup," Molecular biology of the cell 8:
  • Yabe, J., Katchmar, T., Shea, T.B. (1997) "Non-uniform distribution of soluble and insoluble neurofilament immunoreactivity in growing axons," Molecular biology of the cell 8:
  • Shea, T.B. (1997) "Phospholipids alter tau conformation, phosphorylation, proteolysis, and association with microtubules: Implication for tau function under normal and degenerative conditions," Journal of neuroscience research 50:1 pp. 114-122
  • Boyce, J.J., Shea, T.B. (1997) "Phosphorylation events mediated by protein kinase C and participate in regulation of tau steady-state levels and generation of certain 'Alzheimer-like' phospho-epitopes," International Journal of Developmental Neuroscience 15:3 pp. 295-307
  • Shea, T.B., Fischer, I. (1997) "Phosphorylation of high molecular weight tau within neuroblastoma and under cell-free conditions retards its electrophoretic migration and generates 'AD-like' immunoreactivity," Neuroscience Research Communications 21:3 pp. 195-201
  • Jung, C., Shea, T.B. (1997) "Regional decline in neurofilament axonal transport: correlation with NF-H phosphorylation," Molecular biology of the cell 8:
  • Shea, T.B. (1997) "Restriction of M-calcium-requiring calpain activation to the plasma membrane in human neuroblastoma cells: Evidence for regionalized influence of a calpain activator protein," Journal of neuroscience research 48:6 pp. 543-550
  • Ekinci, F.J., Shea, T.B. (1997) "Selective activation by bryostatin-1 demonstrates unique roles for PKC in neurite extension and tau phosphorylation," International Journal of Developmental Neuroscience 15:7 pp. 867-874
  • Shea, T.B., Yabe, J., Jung, C. (1997) "Soluble neurofilament subunits in axons," Molecular biology of the cell 8:
  • Ekinci, F., Pundreddy, S., Wheeler, E., Shea, T.B. (1997) "Tau phosphorylation is regulated by divergent and convergent signal transduction pathways," Journal of neurochemistry 69:
  • Shea, T.B., Dahl, D.C., Nixon, R.A., Fischer, I. (1997) "Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system," Journal of neuroscience research 48:6 pp. 515-523
  • Shea, T.B., Husain, T. (1996) "Astroglial-secreted factors induce the elaboration of unstable axonal neurites by NB2a/d1 neuroblastoma cells: Correlation with deficiencies in MAP1B and phospho-isoforms of the high molecular weight neurofilament subunit," Neuroscience Research Communications 18:1 pp. 63-70
  • Shea, T.B., Spencer, M.J., Beermann, M.L., Cressman, C.M., Nixon, R.A. (1996) "Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: Involvement of calpain-mediated hydrolysis of protein kinase C," Journal of neurochemistry 66:4 pp. 1539-1549
  • Ekinci, F.J., Boyce, J.B., Shea, T.B. (1996) "Differential effects of bryostatin and phorbol esters on neuroblastoma cells: Unique role of protein kinase C epsilon," Journal of neurochemistry 66:
  • Shea, T.B. (1996) "Induction of lysosomal abnormalities and tau hyperphosphorylation in human neuroblastoma cells by colchicine and okadaic acid: Evidence that microtubule disruption contributes to Alzheimer neurodegeneration," Neuroscience Research Communications 19:1 pp. 27-36
  • Shea, T.B., Fischer, I. (1996) "Phosphatase inhibition in human neuroblastoma cells alters tau antigenicity and renders it incompetent to associate with exogenous microtubules," FEBS letters 380:1-2 pp. 63-67
  • Shea, T.B., Cressman, C.M., Fischer, I. (1996) "Preferential translocation of HMW tau isoforms into newly-elaborated neurites in human neuroblastoma," Journal of neurochemistry 66:
  • Boyce, J.J., Ennulat, D.J., Leli, U., Shea, T.B. (1996) "Regulation of neuronal differentiation by the and isoforms of protein kinase C," Neuroscience Research Communications 18:3 pp. 195-201
  • Boyne, L.J., Fischer, I., Shea, T.B. (1996) "Role of vimentin in early stages of neuritogenesis in cultured hippocampal neurons," International Journal of Developmental Neuroscience 14:6 pp. 739-748
  • Cressman, C.M., Boyce, J.B., Wheeler, E., Chang, M., Shea, T.B. (1996) "Site-specific synergism between PKC and MAP kinase in tau hyperphosphorylation in intact SH-SY-5Y human neuroblastoma," Journal of neurochemistry 66:
  • Sihag, R.K., Shea, T.B., Wang, F.S. (1996) "Spectrin-actin interaction is required for neurite extension in NB 2a/dl neuroblastoma cells," Journal of neuroscience research 44:5 pp. 430-437
  • Shea, T.B. (1996) "The influence of surface protease activity on neuritogenesis and neurite retraction is dependent upon mode of neurite induction: Inhibition of thrombin-mediated surface protease activity is cruicial for neurite outgrowth but not for maintenance of existing neurites," Neuroscience Research Communications 19:1 pp. 57-60
  • Cressman, C.M., Mercken, M.M., Shea, T.B. (1995) "Alteration in tau antigenicity and electrophoretic migration by PKC under cell-free conditions," Neuroscience Research Communications 17:2 pp. 61-64
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1995) "Aluminum treatment of intact neuroblastoma cells alters neurofilament subunit phosphorylation, solubility, and proteolysis," Molecular and Chemical Neuropathology 26:1 pp. 1-14
  • Shea, T.B. (1995) "Calcium modulates aluminum neurotoxicity and interaction with neurofilaments," Molecular and Chemical Neuropathology 24:2-3 pp. 151-163
  • Shea, T.B. (1995) "Differential synthesis and cytoskeletal deposition of neurofilament subunits before and during axonal outgrowth in NB2a/d1 cells: Evidence that segregation of phosphorylated subunits within the axonal cytoskeleton involves selective deposition," Journal of neuroscience research 40:2 pp. 225-232
  • Shea, T.B., Cressman, C.M., Spencer, M.J., Beermann, M.L., Nixon, R.A. (1995) "Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C," Journal of neurochemistry 65:2 pp. 517-527
  • Cressman, C.M., Shea, T.B. (1995) "Hyperphosphorylation of Tau and filopodial retraction following microinjection of protein kinase C catalytic subunits," Journal of neuroscience research 42:5 pp. 648-656
  • Shea, T.B., Husain, T. (1995) "Inhibition of proteolysis enhances aluminum-induced perikaryal neurofilament accumulation but does not enhance tau accumulation," Molecular and Chemical Neuropathology 26:3 pp. 195-212
  • Shea, T.B., Wheeler, E., Wang, F.S. (1995) "Neurofilament Translocation into Axonal Neurites is Distinct from Incorporation into the Cytoskeleton," Molecular biology of the cell 6:
  • Lang, D., Beermann, M.L., Hauser, G., Cressman, C.M., Shea, T.B. (1995) "Phospholipids inhibit proteolysis of protein kinase C alpha by mM calcium-requiring calpain," Neurochemical research 20:11
  • Boyce, J.J., Ennulat, D.J., Neve, R., Shea, T.B. (1995) "Pkc-Epsilon and Pkc-Alpha Regulate Tau Levels and Phosphorylation State," Molecular biology of the cell 6:
  • Cressman, C.M., Mohan, P.S., Nixon, R.A., Shea, T.B. (1995) "Proteolysis of protein kinase C: mM and M calcium-requiring calpains have different abilities to generate, and degrade the free catalytic subunit, protein kinase M," FEBS letters 367:3 pp. 223-227
  • Shea, T.B., Beermann, M.L., Wang, F.S. (1995) "Relative Susceptibility of Cytoskeleton-Associated and Soluble Neurofilament Subunits to Aluminum Exposure in Intact-Cells - a Possible Mechanism for Reduction of Neurofilament Axonal-Transport during Aluminum Neurotoxicity," Molecular and Chemical Neuropathology 24:2-3
  • Shea, T.B. (1995) "Role of glial-derived nexin in neuronal differentiation and in acute brain injury and potential involvement in exacerbation of neurodegeneration in Alzheimer's disease," Brain Research Reviews 20:2 pp. 171-184
  • Sihag, R.K., Shea, T.B., Wang, F.S. (1995) "Spectrin-Actin Interaction is Required for Neurite Extension in Nb 2a/d1 Neuroblastoma-Cells," Molecular biology of the cell 6:
  • Shea, T.B. (1994) "Amyloid precursor protein as a glial-derived growth factor," Trends in neurosciences 17:8 pp. 338-339
  • Shea, T.B., Beermann, M.L., Griffin, W.R., Leli, U. (1994) "Degradation of protein kinase C and its free catalytic subunit, protein kinase M, in intact human neuroblastoma cells and under cell-free conditions: Evidence that PKM is degraded by mM calpain-mediated proteolysis at a faster rate than PKC," FEBS letters 350:2?"3 pp. 223-229
  • Shea, T.B. (1994) "Triton-soluble phosphovariants of the high molecular weight neurofilament subunit from NB2a/dl cells are assembly-competent: Implications for normal and abnormal neurofilament assembly," FEBS letters 343:2 pp. 131-136
  • Leli, U., Shea, T.B., Cataldo, A., Hauser, G., Grynspan, F., Beermann, M.L., Liepkalns, V.A., Nixon, R.A., Parker, P.J. (1993) "Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation," Journal of neurochemistry 60:1 pp. 289-98
  • Shea, T.B., Beermann, M.L. (1993) "Evidence that the monoclonal antibodies SMI-31 and SMI-34 recognize different phosphorylation-dependent epitopes of the murine high molecular mass neurofilament subunit," Journal of neuroimmunology 44:1 pp. 117-121
  • Shea, T.B., Balikian, P., Beermann, M.L. (1992) "Aluminum inhibits neurofilament protein degradation by multiple cytoskeleton-associated proteases," FEBS letters 307:2 pp. 195-198
  • Shashoua, V.E., Nolan, P.M., Shea, T.B., Milinazzo, B. (1992) "Dibutyryl cyclic AMP stimulates expression of ependymin mRNA and the synthesis and release of the protein into the culture medium by neuroblastoma cells (NB2a/d1)," Journal of neuroscience research 32:2 pp. 239-44
  • Leli, U., Cataldo, A., Shea, T.B., Nixon, R.A., Hauser, G. (1992) "Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors," Journal of neurochemistry 58:4 pp. 1191-8
  • Leli, U., Parker, P.J., Shea, T.B. (1992) "Intracellular delivery of protein kinase C- or isoform-specific antibodies promotes acquisition of a morphologically differentiated phenotype in neuroblastoma cells," FEBS letters 297:1?"2 pp. 91-94
  • Shea, T.B., Beermann, M.L. (1992) "Regulation of neuronal migration and neuritogenesis by distinct surface proteases Relative contribution of plasmin and a thrombin-like protease," FEBS letters 307:2 pp. 190-194
  • Fischer, I., Shea, T.B. (1991) "Differential appearance of extensively phosphorylated forms of the high molecular weight neurofilament protein in regions of mouse brain during postnatal development," Journal of neuroimmunology 31:1 pp. 73-81
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1991) "Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells," Journal of neurochemistry 56:3 pp. 842-51
  • Shea, T.B., Beermann, M.L. (1991) "Staurosporine-induced morphological differentiation of human neuroblastoma cells," Cell biology international reports 15:2 pp. 161-168
  • Shea, T.B. (1991) "Transient neuritogenesis in NB2a/d1 neuroblastoma cells induced by glial-derived protease inhibitors," Cell biology international reports 15:5 pp. 437-443
  • Shea, T.B., Beermann, M.L. (1990) "Alterations in dynamics of microtubule assembly during axonal neuritogenesis in NB2a/d1 cells," Cell biology international reports 14:12 pp. 1093-1098
  • Shea, T.B. (1990) "Neuritogenesis in mouse NB2a/d1 neuroblastoma cells: Triggering by calcium influx and involvement of actin and tubulin dynamics," Cell biology international reports 14:11 pp. 967-979
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1990) "Post-translational modification of -tubulin by acetylation and detyrosination in NB2a/d1 neuroblastoma cells," Developmental Brain Research 51:2 pp. 195-204
  • Shea, T.B. (1990) "Transient increase in vimentin in axonal cytoskeletons during differentiation in NB2a/d1 cells," Brain research 521:12 pp. 338-342
  • Shea, T.B., Clarke, J.F., Wheelock, T.R., Paskevich, P.A., Nixon, R.A. (1989) "Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma," Brain research 492:12 pp. 53-64
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1989) "Appearance and localization of phosphorylated variants of the high molecular weight neurofilament protein in NB2a/d1 cytoskeletons during differentiation," Developmental Brain Research 50:1 pp. 142-146
  • Shea, T.B., Nixon, R.A. (1988) "Differential distribution of vimentin and neurofilament protein immunoreactivity in NB2a/d1 neuroblastoma cells following neurite retraction distinguishes two separate intermediate filament systems," Developmental Brain Research 41:1?"2 pp. 298-302
  • Newburg, D.S., Shea, T.B., Yatziv, S., Raghavan, S.S., McCluer, R.H. (1988) "Macrophages exposed in vitro to conduritol B epoxide resemble Gaucher cells," Experimental and molecular pathology 48:3 pp. 317-323
  • Shea, T.B., Sihag, R.K., Nixon, R.A. (1988) "Neurofilament triplet proteins of NB2a/d1 neuroblastoma: posttranslational modification and incorporation into the cytoskeleton during differentiation," Developmental Brain Research 43:1 pp. 97-109
  • Shea, T.B., Majocha, R.E., Marotta, C.A., Nixon, R.A. (1988) "Soluble, phosphorylated forms of the high molecular weight neurofilament protein in perikarya of cultured neuronal cells," Neuroscience letters 92:3 pp. 291-297
  • Fischer, I., Nolan, C.E., Shea, T.B. (1987) "Effects of retinoic acid on expression of the transformed phenotype in C6 glioma cells," Life Sciences 41:4 pp. 463-470
  • Fischer, I., Shea, T.B., Sapirstein, V.S., Kosik, K.S. (1986) "Expression and distribution of microtubule-associated protein 2 (MAP2) in neuroblastoma and primary neuronal cells," Developmental Brain Research 25:1 pp. 99-109
  • Shea, T.B., Fischer, I., Sapirstein, V.S. (1985) "Effect of retinoic acid on growth and morphological differentiation of mouse NB2a neuroblastoma cells in culture," Developmental Brain Research 21:2 pp. 307-314

Presentations

  • Pathways to Hope: the latest in Alzheimers research - MA/NH Alzheimers Association Conference, 2009 - Plymouth, NH
  • Nutrition in aging and Alzheimers disease, 2008 - Essex County Professional Networking Group, Peabody MA
  • Results of clinical trials of the SmartPill: a vitamin/nutriceutical formulation that improves cognition and mood in early-stage Alzheimers patients and in seniors without dementia. - Alzheimers Workshop, 2007 - Plymouth MA
  • Nutrition and Alzheimers disease, 2007 - Douville Senior Center, Tewksbury, MA
  • Nutrition and cognition in aging and Alzheimers disease, 2007 - Merrimack Valley River House, Lowell, MA
  • The SmartPill: stopping Alzheimers disease where it starts, 2007 - Emerald Court, Tewksbury, MA
  • An over-the-counter nutriceutical formulation that prevents neuronal oxidative damage, acetylcholine depletion, cognitive decline and buffers Alzheimer risk factors in preclinical studies: are we ready for clinical trials?, 2006 - BU Med School, Boston, MA
  • Clinical trials of apple juice to delay cognitive decline in Alzheimers disease, 2006 - Youville Senior Center, Tewksbury, MA
  • Nutriceutical Formulation 1: a vitamin/nutriceutical formulation that improves cognition and mood in early-stage Alzheimers patients and in seniors without dementia, 2006 - Chicago , Il
  • The SmartPill: clinical trials of a vitamin/nutriceutical formulation that improves cognition and mood in early-stage Alzheimers patients and in seniors without dementia, 2006 - Fallon Clinic, MA
  • Microtubule motors and neurofilament dynamics, 2005 - Drexel University, Philadelphia, PA
  • Folate and Alzheimers disease - Alzheimers Assocation: Map thru the Maze, 2004 - Malboro, MA
  • Brain Nutrients: How folates are linked to Alzheimers disease, 2004 - East Village Place (Assisted Living Group) East Longmeadow, MA
  • Health Benefits from Eating Apples, 2004 - Manchester NH
  • Is Diet a Major Factor in the Occurrence of Alzheimer's Disease? - Explorations in Chemical Education Conference, 2003 - Middlesex Community College, Lowell MA
  • "Suprastructure of Axonal Neurofilaments" - 7th Intermediate Filament Gordon Conference, 2002 - Roger Bristol University, Newport, RI
  • Neurofilament dynamics as revealed by green fluorescent protein, 2002 - Nathan Kline Institute, Orangeburg, NY
  • Nutritional Approaches to Treat Alzheimers Disease, 2002 - The Atrium, Danvers MA
  • Microtubule motors, phosphorylation and neurofilament axonal transport, 2001 - McGill University, CA
  • Motors, kinases and neurofilament axonal transport, 2001 - SUNY at Albany
  • "Microtubule motors, phosphorylation and neurofilament transport of Triton-soluble and -insoluble neurofilament subunits" - 6th Intermediate Filament Gordon Conference, 2000 - Queens College, Oxford, UK
  • Neurofilament transport and phosphorylation, 2000 - NIH, Bethesda, MD
  • "Research Update: Current research on causes, medications and other treatments", 1999 - Lowell, MA
  • "Recent developments in understanding of Alzheimer's disease neuropathology", 1998 - Lowell, MA
  • "Recent developments in understanding of Alzheimer's disease neuropathology", 1998 - McLean Hospital Grand Rounds, Belmont, MA
  • "Axonal transport of Triton-soluble and -insoluble neurofilament subunits" in Neuropathology and Intermediate Filaments - 5th Intermediate Filament Gordon Conference, 1998 - Holderness, New Hampshire
  • Creation of a "virtual" journal club using a threaded newsgroup - Institutional Technology Conference, 1997 - Boxboro, MA
  • Phosphatidyl serine alters tau antigenicity and phosphorylation by a non-PS-dependent kinase - Mass Alzheimer's Disease Scientific Symposium, 1997 - Boston, MA
  • TGF-2 dependent protection towards and exacerbation of beta-amyloid toxicity. - Mass Alzheimer's Disease Scientific Symposium, 1997 - Boston, MA
  • Initial transport of neurofilament subunits in mouse optic pathway occurs at a rate in excess of slow component a: correlation of slowing of transport with neurofilament phosphorylation - Workshop on Neuronal Plasticity, Development and Regeneration, 1997 - University of Massachusetts at Lowell, Lowell, MA
  • Pivotal role of the calpain/PKC system in neuronal differentiation and degeneration, 1996 - St. Elizabeth's Hospital, Boston, MA
  • Pivotal role of the calpain/PKC system in neuronal differentiation and degeneration, 1996 - McLean Hospital, Belmont, MA
  • Pivotal role of the calpain/PKC system in neuronal homeostasis, 1996 - Bayer Corporation, New Haven, CT
  • Lipids inhibit mM calpain-mediated PKC proteolysis - 26th Annual Meeting of the American Society for Neurochemistry, 1995 - Santa Monica, CA
  • Sequential cytoskeletal protein requirements for axonal outgrowth and stabilization - 25th Annual Meeting of the American Society for Neurochemistry, 1994 - Albequerque, New Mexico
  • Sequential requirement for cytoskeletal and membrane skeletal proteins for axonal neurite initiation, outgrowth and stabilization, 1994 - Hershey Medical Center, Hershey, PA
  • Sequential requirement for cytoskeletal and membrane skeletal constituents for axonal neurite initiation, outgrowth and stabilization, 1993 - University of Massachusetts at Lowell, Lowell, MA
  • Potential involvement of neuronal surface proteinases and their glial-derived inhibitors in the nervous system - 21st Annual Meeting of the American Society for Neurochemistry, 1991 - Charleston, South Carolina
  • Soluble 200 kDa NF-H in mouse brain during postnatal development - 21st Annual Meeting of the American Society for Neurochemistry, 1991 - Charleston, South Carolina
  • Sequential requirement of cytoskeletal constituents for initiation and maturation of axonal neurites, 1991 - E. K. Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Cytoskeletal dynamics accompanying axonal outgrowth in cultured neuronal cells - 1st Annual Biology of Neuronal Disorders International Workshop, 1990 - Belmont, Massachusetts
  • Epigenetic events in the induction of axonal neurites: Dependence upon microenvironmental clues, 1990 - Boston University School of Public Health, Boston, Massachusetts
  • Vimentin and neurofilament expression during axon outgrowth in vitro - 20th Annual Meeting of the American Society for Neurochemistry, 1989 - Chicago, Illinois
  • Argyrophilic deposits form in perikarya of aluminum-treated NB2a/d1 cells - 19th Annual Meeting of the American Society for Neurochemistry, 1988 - New Orleans, Louisiana
  • Phosphorylated 200kD neurofilament protein in NB2a/d1 perikarya - 19th Annual Meeting of the American Society for Neurochemistry, 1988 - New Orleans, Louisiana
  • Maintenance of axonal stability: Relationship to posttranslational modification of cytoskeletal proteins - 1st Annual American Federation for Aging Research Conference, 1988 - Briarcliff Manor, New York
  • Cytoskeletal dynamics during early stages of differentiation in cultured neurons, 1988 - E. K. Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Induction of "neurofibrillary pathology" in NB2a/d1 neuroblastoma cells, 1987 - Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Expression of neurofilament proteins by differentiated neuroblastoma cells., 1986 - Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Synthesis of a neural plasma membrane proteolipid - 16th Meeting of the American Society for Neurochemistry, 1985 - Baltimore, Maryland
  • Process outgrowth in cultured embryonic rat neurons - 35th Meeting of the Tissue Culture Association, 1984 - Houston, Texas
  • Spectrin-binding protein, Band 4.1, in glial cells, 1984
  • A serum-free medium for fish cell cultures, 1983
  • Air Bladder-III cells: a new continuous cell line from goldfish, 1983
  • Pesticides and viral infections: are "safe" levels of pesticides truly safe?, 1983 - Massachusetts State Laboratories, Boston, Massachusetts
  • Suppression of an interferon-like activity as a possible mechanism for enhancement of Goldfish Virus-2 by the pesticide carbaryl - Phi Sigma Symposium, 1983 - Marine Science Institute, Nahant, Massachusetts
  • Interaction of Iridovirus GFV-2 in vitro with the pesticides carbaryl and toxaphene, 1982
  • Interactions of the pesticides toxaphene and carbaryl with viruses and cell cultures derived from Carassius auratus - Phi Sigma Symposium, 1982 - Marine Science Institute, Nahant, Massachusetts
  • Replication and physicochemical properties of two Iridovirus isolates from goldfish (Carassius auratus), 1982
  • A flagellartropic bacteriophage of Bacillus subtilis - XIII International Congress for Microbiology, 1982
  • Goldfish Virus-2 (GFV-2): A new Iridovirus isolated from Carassius auratus - Phi Sigma Symposium, 1981 - Marine Science Institute, Nahant, Massachusetts

Intellectual Property

  • Patent - Shea, T.B."An over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in AlzheimerÍs disease and normal aging.," UML-08-04
  • Patent - Shea, T.B."An Anti-Oxidant Synergy Formulation that promotes neuronal survival and prevents neurodegeneration," UML-97-14-19

Contracts, Fellowships, Grants and Sponsored Research

  • (2013), - National Science Foundation
    Shea, T. (Principal)
  • Dietary Supplementation with a Nutriceutical Formulation to Delay Motor Neuron De (2011), -
    Shea, T.B. (Principal)
  • (2011), - Army Research Office
    Shea, T. (Principal)
  • Development and Refinement of a Computer/Neuronal Robotics Interface (2011), Grant -
    Shea, T.B. (Principal)
  • Equipment to Support Development of Neuronal Network Controlled Robots (2013), Contract -
    Shea, T.B. (Co-Principal)
  • (2012), - Adelard A and Valeda Lea Roy Foundation
    Shea, T. (Principal)
  • (2008), - AlzheimerÍs Association
    Shea, T. (Principal)
  • (2010), - National Science Foundation
    Shea, T. (Principal)
  • How Does Phosphorylation Regulate Neurofilament Transport? (2009), Grant -
    Shea, T.B. (Principal)
  • Model of Learning in Neuronal Culture (2010), Grant -
    Shea, T.B. (Principal)
  • (2009), - US Army
    Shea, T. (Principal)
  • (2007), - National Institute on Aging
    Shea, T. (Principal)
  • (2003), - US Apple Products Research and Education Council
    Shea, T. (Principal)
  • Optimization of a Neuronal-computer Interface (2008), Contract -
    Shea, T.B. (Principal)
  • (2008), - National Institute of Health
    Shea, T.
  • (2007), - National Institute on Aging
    Shea, T. (Principal)
  • (2006), - US Apple Products Research and Education Council
    Shea, T. (Principal)
  • (2004), - National Pecan Shellers Association
    Shea, T. (Principal)
  • A preclinical trial of Memacin for neuroprotection and cognitive benefit (2007), Grant -
    Shea, T.B. (Principal)
  • (2007), - US Army
    Shea, T. (Principal)
  • Subcontract from US Army STTR to Infoscitex Corp (2006), Contract -
    Shea, T. (Principal)
  • (2006), - UMass Lowell Chancellors Fund
    Shea, T. (Principal)
  • (1999), - National Science Foundation
    Shea, T. (Principal)
  • (2004), - National Institutes of Health
    Shea, T. (Principal)
  • (2002), - AlzheimerÍs Association
    Shea, T. (Principal)
  • (2003), - National Science Foundation
    Shea, T.
  • (2003), - National Science Foundation
    Shea, T.
  • (2002), - Processed Apples Institute
    Shea, T. (Principal)
  • UMass Lowell Healy Grant (2002), Grant -
    Shea, T. (Principal)
  • (2000), - UMass Lowell Research Foundation
    Shea, T. (Co-Principal)
  • (1997), - National Institutes of Health
    Shea, T.
  • (1998), - National Science Foundation
    Shea, T. (Principal)
  • (1998), - Office of Elder Affairs
    Shea, T. (Principal)
  • (1997), - National Science Foundation
    Shea, T. (Principal)
  • (1996), - National Science Foundation
    Shea, T. (Co-Principal)
  • (1994), - National Institute on Aging
    Shea, T. (Principal)
  • (1996), - Amyotrophic Lateral Sclerosis Association
    Shea, T. (Principal)
  • Joseph P. Healey Endowment (1996), Grant -
    Shea, T. (Principal)
  • (1991), - National Institute of Mental Health
    Shea, T. (Principal)
  • (1995), - Massachusetts Alzheimer's Disease Research Center Program Project, National Institutes on Aging
    Shea, T. (Principal)
  • R01 Subproject in Leadership and Excellence in Alzheimer's Disease (LEAD) Program Project (1992), -
    Shea, T.
  • (1990), - National Science Foundation
    Shea, T. (Principal)
  • Massachusetts Alzheimer's Disease Research Center Program Grant (1989), Grant - National Institutes of Health
    Shea, T. (Co-Principal)
  • (1988), - National Science Foundation
    Shea, T. (Principal)
  • (1990), - Alzheimer's Association
    Shea, T. (Principal)
  • William F. Milton Fund Award (1991), -
    Shea, T. (Principal)
  • (1988), - Amyotrophic Lateral Sclerosis Association, Inc.
    Shea, T. (Principal)
  • (1987), - Medical Foundation, Inc.
    Shea, T. (Principal)
  • (1987), - American Foundation for Aging Research, Inc
    Shea, T. (Principal)