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Jeffrey R. Moore

image of Jeffrey Moore
Jeffrey R. MooreProfessor, Graduate Coordinator

Research Interests

The study of molecular mechanics and cellular motility. Cell motility, regulation of cell shape and the mechanism and regulation of muscle contraction.

Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties and tropomyosin’s ability to regulate muscle contraction via the calcium/troponin system. We are also investigating actin filament network mechanics and the regulation of cytoskeletal dynamics.

Education

  • Other: Molecular Physiology & Biophysics, (2003), University of Vermont - Vermont
  • Ph D: Cell & Molecular Biology, (1999), University of Vermont - Vermont
  • MS: Biological Sciences, (1993), UMass Lowell - Massachusetts
  • BS: Biological Sciences, (1991), University of Lowell (UL) - MA

Selected Publications

  • Dutta, S., Tsiros, C., Sundar, S.L., Athar, H., Moore, J.R., Nelson, B., Gage, M., Nishikawa, K. (2018) "Calcium increases titin N2A binding to F-actin and regulated thin filaments.", Scientific reports 8:1 pp. 14575
  • Lehman, W., Li , X., Kiani, F.A., Moore, J.R., Campbell, S.G., Fischer, S., Rynkiewicz, M.J. (2018) "Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting.", Biophysical journal 115:6 pp. 1082-1092
  • Farman, G.P., Rynkiewicz, M.J., Orzechowski, M., Lehman, W., Moore, J.R. (2018) "HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.", Archives of biochemistry and biophysics 647: pp. 84-92
  • Rynkiewicz, M.J., Prum, T., Hollenberg, S., Kiani, F.A., Fagnant, P.M., Marston, S.B., Trybus, K.M., Fischer, S., Moore, J.R., Lehman, W. (2017) "Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.", Biophysical journal 113:11 pp. 2444-2451
  • Guo, M., Pegoraro, A.F., Mao, A., Zhou, E.H., Arany, P.R., Han, Y., Burnette, D.T., Jensen, M.H., Kasza, K.E., Moore, J.R., Mackintosh, F.C., Fredberg, J.J., Mooney, D.J., Lippincott-Schwartz, J., Weitz, D.A. (2017) "Cell volume change through water efflux impacts cell stiffness and stem cell fate.", Proceedings of the National Academy of Sciences of the United States of America 114:41 pp. E8618-E8627
  • Egan, P.F., Moore, J.R., Ehrlicher, A.J., Weitz, D.A., Schunn, C., Cagan, J., LeDuc, P. (2017) "Robust mechanobiological behavior emerges in heterogeneous myosin systems.", Proceedings of the National Academy of Sciences of the United States of America 114:39 pp. E8147-E8154
  • Achal, M., Trujillo, A.S., Melkani, G.C., Farman, G.P., Ocorr, K., Viswanathan, M.C., Kaushik, G., Newhard, C.S., Glasheen, B.M., Melkani, A., Suggs, J.A., Moore, J.R., Swank, D.M., Bodmer, R., Cammarato, A., Bernstein, S.I. (2016) "A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.", Journal Of Molecular Biology 428:11 pp. 2446 - 2461
  • Sewanan, L.R., Moore, J.R., Lehman, W., Campbell, S.G. (2016) "Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling.", Frontiers In Physiology 7: pp. 473
  • Moore, J.R., Campbell, S.G., Lehman, W. (2016) "Structural Determinants of Muscle Thin Filament Cooperativity.", Archives Of Biochemistry And Biophysics 594: pp. 8 - 17
  • Fischer, S., Rynkiewicz, M.J., Moore, J.R., Lehman, W. (2016) "Tropomyosin Diffusion over Actin Subunits Facilitates Thin Filament Assembly.", Structural Dynamics (Melville, N.Y.) 3:1 pp. 012002
  • Karabina, A., Kazmierczak, K., Szczesna-Cordary, D., Moore, J.R. (2015) "Myosin Regulatory Light Chain Phosphorylation Enhances Cardiac ß-Myosin in Vitro Motility Under Load", Archives of Biochemistry and Biophysics 580: pp. 14-21
  • Schmidt, W.M., Lehman, W., Moore, J.R. (2015) "Direct Observation of Tropomyosin Binding to Actin Filaments", Cytoskeleton 72:6 pp. 292-303
  • Lehman, W., Medlock, G., Li, X.E., Suphamungmee, W., Tu, A., Schmidtmann, A., Ujfalusi, Z., Fischer, S., Moore, J.R., Geeves, M.A., Regnier, M. (2015) "Phosphorylation of Ser283 Enhances the Stiffness of the Tropomyosin Head-To-Tail Overlap Domain", Archives of Biochemistry and Biophysics 571: pp. 10-15
  • Egan, P., Moore, J.R., Schunn, C., Cagan, J., LeDuc, P. (2015) "Emergent Systems Energy Laws for Predicting Myosin Ensemble Processivity", PLoS Computational Biology 11:4 pp. e1004177
  • Farman, G.P., Muthu, P., Kazmierczak, K., Szczesna-Cordary, D., Moore, J.R. (2014) "Impact of Familial Hypertrophic Cardiomyopathy-Linked Mutations in the NHsub 2 Terminus of the RLC [Beta]-Myosin Cross-Bridge Mechanics", Journal of applied physiology 117:12 pp. 1471
  • Orzechowski, M., Fischer, S., Moore, J.R., Lehman, W., Farman, G.P. (2014) "Energy Landscapes Reveal the Myopathic Effects of Tropomyosin Mutations", Archives of Biochemistry and Biophysics 564: pp. 89-99
  • Muthu, P., Liang, J., Schmidt, W., Moore, J.R., Szczesna-Cordary, D. (2014) "In Vitro Rescue Study of a Malignant Familial Hypertrophic Cardiomyopathy Phenotype by Pseudo-Phosphorylation of Myosin Regulatory Light Chain", Archives of Biochemistry and Biophysics 552-553: pp. 29-39
  • Jensen, M., Morris, E., Gallant, C., Morgan, K., Weitz, D., Moore, J. (2014) "Mechanism of Calponin Stabilization of Crosslinked Actin Networks", Biophysical Journal 106: pp. 793-800
  • Orzechowski, M., Moore, J.R., Fischer, S., Lehman, W. (2014) "Tropomyosin Movement on f-Actin During Muscle Activation Explained by Energy Landscapes", Archives of Biochemistry and Biophysics 545: pp. 63-68
  • Huang, W., Liang, J., Kazmierczak, K., Muthu, P., Duggul, D., Farman, G.P., Sorenson, L., Pozios, I., Abraham, T.P., Moore, J.R., Borejdo, J., Szczesna-Cordary, D. (2014) "Hypertrophic Cardiomyopathy Associated Lys104Glu Mutation in the Myosin Regulatory Light Chain Causes Diastolic Disturbance in Mice", Journal of Molecular and Cellular Cardiology 74: pp. 318-329
  • Guo, M., Ehrlicher, A.J., Jensen, M.H., Renz, M., Moore, J.R., Goldman, R.D., Lippincott-Schwartz, J., Mackintosh, F.C., Weitz, D.A. (2014) "Probing the Stochastic, Motor-Driven Properties of the Cytoplasm Using Force Spectrum Microscopy", Cell 158:4 pp. 822-832
  • Saphirstein, R., Gao, Y., Jensen, M., Gallant, C., Vetterkind, S., Moore, J.R., Morgan, K. (2013) "The Focal Adhesion: A Regulated Component of Aortic Stiffness", PLoS One 23:8 pp. 4 e62461
  • Guo, M., Ehrlicher, A., Mahammad, S., Fabich, H., Jensen, M., Moore, J.R., Fredberg, J., Goldman, R., Weitz, D. (2013) "The Role of Vimentin Intermediate Filaments in Cortical and Cytoplasmic Mechanics", Biophysical Journal 105:7 pp. 1562-1568