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The study of molecular mechanics and cellular motility. Cell motility, regulation of cell shape and the mechanism and regulation of muscle contraction.
Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties and tropomyosin’s ability to regulate muscle contraction via the calcium/troponin system. We are also investigating actin filament network mechanics and the regulation of cytoskeletal dynamics.