Project 3

GWAS for Cardiovascular Health in Elderly Puerto Ricans

Project Director: José M. Ordovás, Ph.D.

This project will build on our previous genetic analysis to genotype 1500 Puerto Rican adults currently participating in the Boston Puerto Rican Health Study.

  • We will utilize the genome-wide association study (GWAS) data to target genetic regions for further analysis in relation to CVD risk measures over 5 years, and to 5 year measures of CVD and type 2 diabetes
  • We will replicate findings observed in this population for CVD risk and type 2 diabetes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) and Nutrition, Aging, and Memory in Elders (NAME)studies
  • We will complete detailed statistical analyses of specified genes with CVD risk factors, and type 2 diabetes, in interaction with environmental variables, including dietary intake, body weight, physical activity, acculturation and psychosocial stress