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Boston Puerto Rican Health Study Projects

The Boston Puerto Rican Health Study is composed of 5 interrelated research projects, centered on our established cohort of 1500 Puerto Ricans, aged 45-75 years at baseline. Projects 1-4 directly build upon data obtained in the first two interview cycles (baseline and 2-year), during the initial funding period, by adding additional measures in a third 5-year interview. These additional measures include:

  • Project 1 - heart disease risk
  • Project 2 - additional measures of the social environment
  • Project 3 - the role of genetic factors in heart disease risk progression
  • Project 4 - and the role of air pollution on heart disease risk

Each of these projects examines overlapping aspects of likely causal direction in the progression from social determinants of stress to health behavior to allostatic load and biochemical risk factors and on toward evidence of CVD, in the presence of genetic variability. With three points, over five years, we will be able to examine linear relationships with changes in multiple measures using new statistical modeling procedures that maximize the use of data.

  • Project 5 - a multidimensional community-based intervention focusing on diet and exercise, with consideration of social integration to reduce heart disease risk.

This intervention was conducted with participants who are not in the cohort, but who are living in the same communities.

Questionnaires in English

Questionnaires are in PDF format. You will need Adobe Reader in order to view them. It can be downloaded for free from the Adobe website.

Los Cuestionario en Espanol

Cuestionarios estan en formato PDF. Usted necesitará Adobe Reader para verlos. Se puede descargar de forma gratuita desde el sitio web de Adobe.


  • Mattei JM, Sotos-Prieto M, Bigornia SJ, Noel SE, Tucker KL. The Mediterranean diet score is more strongly associated with favorable cardiometabolic risk factors over 2 years than other diet quality indexes in Puerto Rican adults. J Nutr Apr 2017;147:661-9. PMCID: PMC5368589 (Link to PubMed)

  • Zhang Y, Cifuentes M, Gao X, Amaral G, Tucker KL. Age and gender-specific associations between insomnia and falls in Boston Puerto Rican adults. Qual Life Res 2017;26(1):25-34. (Link to PubMed)
  • Smith CE, Fullerton SM, Dookeran KA, Hampel H, Tin A, Maruthur NM, Schisler JC, Henderson JA, Tucker KL, Ordovas JM. Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities. Health Aff 2016;35:1367-73. (Link to PubMed)
  • Noel SE, Arevalo S, Smith CE, Lai CQ, Dawson-Hughes B, Ordovas JM, Tucker KL. Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study. J Bone Miner Metab. 2016 Sep 14. [Epub ahead of print] PMCID: PMC5400727 (Link to PubMed
  • Smith CE, Coltell O, Sorli JV…Tucker KL, Arnett DK, Ordovas JM, Corella D (of 22 authors). Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease mortality: Mendelian randomization. Sci Rep Sept 2016 14;6:33188. doi 10.1038/srep33188. PMCID: PMC5021998 (Link to PubMed)
  • Wong JC, Scott T, Wilde P, Li NHY, Tucker KL, Gao X. Food insecurity is associated with subsequent cognitive decline in the Boston Puerto Rican Health Study. J Nutr Sept 2016;146:1740-5. PMCID: PMC4997276 (Link to PubMed)
  • Blanco-Rojo R, Delgado-Lista J, Lee YC, Lai CQ, Perez-Martinez P, Rangel-Zuniga O, Smith CE, Hildago B, Alcala-Diaz JF, Gomez-Delgado F, Parnell LD, Arnett DK, Tucker KL, Lopez-Miranda J, Ordovas JM. Interaction of a S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries. Am J Clin Nutr Aug 2016;104:508-17. PMCID: PMC4962160 (Link to PubMed)
  • Mattei J, Mendez J, Falcon LM, Tucker KL. Perceptions and motivations to prevent heart disease among Puerto Ricans. Am J Health Beh 2016;40:322-331. PMCID: PMC4897961 (Link to PubMed)
  • Bigornia SJ, Harris WS, Falcón LM, Ordovás JM, Lai CQ, Tucker KL. The omega-3 index is inversely associated with depressive symptoms among individuals with elevated oxidative stress biomarkers. J Nutr 2016;146(4):758-66. PMCID: PMC4807643 (Link to PubMed)
  • Bigornia SJ, Lichtenstein AH, Harris WS, Tucker KL. Associations of erythrocyte fatty acid patterns with insulin resistance. Am J Clin Nutr 2016;103:902-9. PMCID: PMC4763498 (Link to PubMed)
  • Sotos-Prieto M, Bhupathiraju SN, Falcon LM, Gao X, Tucker KL, Mattei J. Association between a healthy lifestyle score and inflammatory markers among Puerto Rican adults. Nutr Metab Cardiovasc Dis 2016;26:178-84. PMCID: PMC4788524 (Link to PubMed)
  • Glik D, Sharif MZ, Tucker KL, Tejada SA, Prelip ML, Ammerman AS, Keyserling TC, Torres SE, Pitts SJ. Community engagement to support cardiovascular disease prevention in disparities populations: three case studies. J Health Dispar Res Pract Apr 2016;9:71-87. (Link to J Health Dispar Res Pract)
  • Guzzardo MT, Adams WE, Todorova IL, Falcón LM. Resonating sentiments on Puerto Rican identity through poetry: Voices of the diaspora. Qualitative Inquiry 2016 doi: 10.1177/1077800415622485 [Epub ahead of print] (Link to Qualitative Inquiry)
  • Guzzardo MT, Todorova IL, Adams WE, Falcón LM. “Half Here, Half There”: Dialogical Selves Among Older Puerto Ricans of the Diaspora. J Constr Psychol 2016;29(1):51-65. (Link to J Constr Psychol
  • Dashti HS, Aslibekyan S, Scheer FAJL, Smith CE, Lamon-Fava S, Jacques P, Lai C-Q, Tucker KL, Arnett DK, Ordovas JM. Clock genes explain a large proportion of phenotypic variance in systolic blood pressure and this control is not modified by environmental temperature. Am J Hypertens 2016;29(1):132-40. (Link to PubMed)


  • Philip D, Buch A, Moorthy D, Peter I, Scott TM, Parnell LD, Lai CQ, Ordovás JM, Selhub J, Rosenberg IH, Tucker KL, Troen AM. Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults. Am J Clin Nutr 2015;102:1279-1288. (Link to PubMed)
  • Dashti HS, Aslibekyan S, Scheer FAJL, Smith CE, Lamon-Fava S, Jacques P, Lai C-Q, Tucker KL, Arnett DK, Ordovas JM. Clock genes explain a large proportion of phenotypic variance in systolic blood pressure and this control is not modified by environmental temperature. Am J Hypertens 2015. doi: 10.1093/ajh/hpv082 [Epub ahead of print] (Link to PubMed)
  • Palacios C, Trak MA, Betancourt J, Joshipura KJ, Tucker KL. Validation and reproducibility of a semi-quantitative FFQ as a measure of dietary intake in adults from Puerto Rico. Pub Health Nutr 2015;18:2550-8. (Link to PubMed)
  • Niu J, Sahni S, Liao S, Tucker KL, Dawson-Hughes B, Gao X. Association between sleep duration, insomnia symptoms and bone mineral density in older Puerto Rican adults. PloS One 2015;10(7):e0132342. doi: 10.1371/journal.pone.0132342. eCollection 2015. PMCID:PMC4493039 (Link to PubMed)
  • Cornelis MC, Byrne EM, Esko T…Tucker KL…Chasman DI (of 75 authors). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry 2015;20:647-56. PMCID:PMC4388784 (Link to PubMed)
  • Cooper L, Ortega AN, Ammerman AS, Buchwald D, Paskett ED, Powell LH, Thompson B, Tucker KL, Warnecke RB, McCarthy WJ, Viswanath KV, Henderson JA, Calhoun EA, Williams DR. Calling for a bold new vision of health disparities intervention research. Am J Pub Health 2015;105:S374-6. PMCID:PMC4455513 (Link to PubMed)
  • Rioux CL, Tucker KL, Brugge D, Mwamburi M. Medication type modifies inflammatory response to traffic exposure in a population with type 2 diabetes. Environ Pollut 2015;202:58-65. (Link to PubMed)
  • Sotos-Prieto M, Bhupathiraju SN, Falcon LM, Gao X, Tucker KL, Mattei J. A Healthy Lifestyle Score is associated with cardiometabolic and neuroendocrine risk factors among Puerto Rican adults. J Nutr 2015;145:1531-40. PMCID: PMC4478944 (Link to PubMed)
  • Arévalo SP, Tucker KL, Falcón LM. Beyond cultural factors to understand immigrant mental health: Neighborhood ethnic density and the moderating role of pre-migration and post-migration factors.Soc Sci Med 2015;138:91-100. PMCID: PMC4498998 (Link to PubMed)
  • Guzzardo MT, Todorova IL, Adams WE, Falcón LM. “Half Here, Half There”: Dialogical Selves Among Older Puerto Ricans of the Diaspora. J Constr Psychol 2015. doi: 10.1080/10720537.2015.1016640 [Epub ahead of print] (Link to J Constr Psychol)
  • Adams WE, Todorova IL, Guzzardo MT, Falcón LM. 'The problem here is that they want to solve everything with pills': medication use and identity among Mainland Puerto Ricans. Sociol Health Illn 2015;37(6):904-19. PMCID: PMC4521983 (Link to PubMed)
  • Jiménez MP, Osypuk TL, Areva S, Tucker KL, Falcon LM. Neighborhood socioeconomic context and change in allostatic load among older Puerto Ricans: The Boston Puerto Rican health study. Health & Place 2015;33:1–8. doi:10.1016/j.healthplace.2015.02.001 [Epub ahead of print] PMCID: PMC4409499 (Link to PubMed
  • Fullerton SM, Anderson EE, Cowan K, Malen RC, Brugge D. Awareness of Federal Regulatory Mechanisms Relevant to Community-Engaged Research: Survey of Health Disparities-Oriented NIH-Funded Investigators. J Empir Res Hum Res Ethics 2015;10(1):13-21. PMCID: PMC4413468 (Link to PubMed)
  • Flores AM, Nelson J, Martinez Tyson D, Stephenson R, Tucker KL. Physical and functional impairments and physical therapy utilization in cancer survivors of Puerto Rican descent. J Oncol Navigation & Survivorship (JONS-online) 2015;6(3):46-55. (Link to JONS-online)
  • Todorova IL, Guzzardo MT, Adams WE, Falcón LM. Gratitude and longing: Meanings of health in aging for Puerto Rican adults in the mainland. J Health Psychol. 2015;20(12):1602-12. (Link to PubMed)
  • Andrews Chavez J, Lee CS, Houser RF, Falcon LM, Tucker KL. Factors Associated with Alcohol Consumption Patterns in a Puerto Rican Urban Cohort. Pub H Nutr 2015;18(3):44-73. (Link to PubMed)
  • Adams WE, Todorova IL, Falcon LM. Puerto Rican Crime and Victimization on the Mainland: The Role of Acculturation. Hispanic J Behav Sci. 2015;37(1):59-74. (Link to Hispanic J Behav Sci)

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See Publications 2011-2014.

See Publications 2005 - 2010.

Potential models

If interested in using our data for research, please fill out the following manuscript proposal form (doc).

Please send the completed form to