Center for Cellular Neurobiology and Neurodegeneration Research

Publications

Publications (from a total of 231) 2005-present only

2012Shea TB, Remington R (2012) Positive argument for debate in J Neural Transmission: Alzheimer's disease: are we intervening too late?  Yes, by decades. J Neural Trans: in press
2013 Sunil N, Lee S and Shea TB (2012) Interference with Kinesin-Based Anterograde Neurofilament Axonal Transport Increases Neurofilament-Neurofilament Bundling. Cytoskeleton: in press.
2012 Zemianek J, Serra M, Guaraldi M, Shea TB. Stimulation with a low-amplitude, digitized synaptic signal to invoke robust activity within neuronal subpopulations on multielectrode arrays. Biotechniques 52:177-182.
2012 Shea TB, Rogers E, Remington R (2012) Nutrition and Dementia: Are we asking the right questions? J Alz dis: in press Feb 20 Epub ahead of print.
2012 Lortie JJ, Remington R, Hoffman H and Shea TB.  Lack of correlation of WAIS Digit Span with Clox1 and Dementia Rating Scale in MCI. Int J Alz dis: in press.
2011 Shea TB, Remington R (2011) Efficacy of Randomized Start Design for Clinical Studies of Cognitive Performance. J Alz dis. http://www.j-alz.com/letterseditor/index.html Oct 2011
2011 Lee S, Sunil N, Tejada JM and Shea TB (2011) Differential roles of kinesin and dynein in translocation of neurofilaments into axonal neurites. J Cell Sci 124: 1022-1031.
2011 Lee S, Suni N and Shea TB (2011) C-Terminal Neurofilament Phosphorylation Fosters Neurofilament- Neurofilament Associations That Compete with Axonal Transport. Cytoskel 68: 8-17.
2011 Lee S, Lemere C, Frost J and Shea TB (2011) Dietary supplementation with S-adenosyl methionine delayed Abeta and tau pathology in 3xTg-AD mice. J Alz dis 28: 423-431.
2011 Lee S, Hall G and Shea TB (2011) Potentiation of Tau Aggregation by cdk5 and GSK3β. J Alz dis 26: 365-376.
2011 Lee S, Doulames V, Donnelly M, Levasseau J and Shea TB (2011) Environmental Enrichment Can Prevent Cognitive Decline Induced By Dietary Oxidative Challenge In Mice.  J Alz dis 28:497-501.
2011 Chan A, Ortiz D, Rogers E and Shea TB (2011) Supplementation with apple juice can compensate for folate deficiency in a mouse model deficient in methyltetrahydrofolate reductase activity. J Nutri Health Aging 110: 221-225.
2010 Serra M, Guaraldi M and Shea TB (2010) Inhibitory neurons modulate spontaneous signaling in cultured cortical neurons: density-dependent regulation of excitatory neuronal signaling. Phys Biol 7: 026009.
2010 Remington R, Chan A, Lepore A, Kotlya E and Shea TB (2010) Apple Juice Improved Behavioral symptoms in Moderate- to Late-Stage Alzheimer's disease in an Open-label Pilot Study. Am J Alz Dis Other Dementias 25: 367-371
2010 Kushkuley J, Metkar S, Chan W K-H, and Shea TB (2010) Aluminum induces neurofilament aggregation by stabilizing cross-bridging of phosphorylated c-terminal sidearms.  Brain Res 1322:118-123.
2010 Chan A, Lepore A, Kotoya E, Zemianek J, Remington R and Shea TB (2010) Efficacy of a vitamin/nutriceutical formulation on cognitive speed and recall in adults with no known or suspected dementia. J Nutri Health Aging 14: 224-230.
2010 Chan A and Shea TB (2010) Apolipoprotein E3 as a risk factor for Alzheimer's disease under conditions of nutritional imbalance.  J Alz dis 20:1-8.
2009 Suchy J, Lee S, Ahmed A, and Shea TB (2009) S-adenosyl methionine delays the onset of neuromuscular decline in mice overexpressing G93/A-mutant human SuperOxide Dismutase-1. Neuromol Medicine 12:86-97.
2009 Suchy J, Lee S, Ahmed A, and Shea TB (2009)  Dietary supplementation with pecans delays the onset of neuromuscular decline in mice overexpressing G93/A-mutant human SuperOxide Dismutase-1. Curr Top Nutr Res 29: 70-74.
2009 Suchy J, Chan A and Shea TB. (2009) Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glucerophosphocoline, docosahexeonic acid and phosphatidyl serine reduces oxidative damage to murine brain and improves cognitive performance.  Nutrition Res 29: 70-74.
2009 Serra M and Shea TB (2009) Apple juice stimulates organized synaptic activity in cultured cortical neurons. Current Topics Nutraceutical Res 7:93-96.
2009 Remington R, Chan A, Tchantchou F, Ortiz D and Shea TB (2009) Neuroprotective effects of Apples on Cognition and Alzheimer's disease.  Agro Food Industry HighTech: 20.
2009 Remington R, Chan A and Shea TB (2009) Efficacy of a vitamin/nutriceutical formulation for moderate to late-stage Alzheimer's disease: A placebo-controlled pilot study. Am J Alz Dis Other Dementias 24: 27-33.
2009 Kushkuley J, Chan W K-H, Lee S, Eyer J, Leterrier J-F, Letournel F and Shea TB (2009) Neurofilament cross-bridging competes with kinesin-dependent microtubule association and may regulate transport. J Cell Sci 122:3579-3586
2009Kifle K, Ortiz D and Shea TB (2009) Folate and B12 provide superior neuroprotection in combination than does either vitamin alone. J Alz dis 16:533-540
2009 Chan A, Tchantchou F, Rogers E and Shea TB. (2009) Dietary deficiency differentially regulates presenilin expression, gamma-secretase activity and Abeta levels as a function of ApoE genotype: role of S-adenosyl methionine. J Neurochem 110: 831-836.
2009 Chan A, Tchantchou F, Rogers E and Shea TB (2009) Tau phosphorylation is differentially regulated by dietary deficiency as a function of ApoE genotype: role of S-adenosyl methionine J Alz dis 17: 483-487.
2009 Chan A and Shea TB. (2009) Supplementation with apple juice decreases endogenous Abeta levels in murine brain. J Alz dis 16:167-171
2008 Tchantchou F, Graves M, Falcone D and Shea TB (2008) S-adenosylmethionine mediates glutathione efficacy by increasing glutathione s-transferase activity:  Implications for S-adenosyl methionine as a neuroprotective dietary supplement. J Alz Dis 14:323-328.
2008 Tagne JB, Kakumanu S, Oritz D, Shea TB, Nicolosi RJ (2008) A nanoemulsion formulation of tamoxifen increases its efficacy in a breast cancer cell line. Mol Pharm 5:280-286.
2008 Shea TB  and Chan A (2008) S-adenosyl methionine: a natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer's disease.  J Alz disease 13:67-70.
2008 Serra M, Dubey M, Chan A, Gilman V and Shea TB. (2008) A low-cost data acquisition interface for multi-electrode array culture systems.  Biotechniques 45:451, 453-4, 456
2008 Serra M, Chan A, Dubey M, Gilman V and Shea TB (2008). Folate and S-adenosymethionine modulate synaptic activity in cultured cortical neurons: differential impact on normal and apolipoprotein E-deficient mice.  Phys Biol 5:44002.
2008 Perry S, Levasseau J, Chan A and Shea TB. (2008) Dietary supplementation with S-adenosyl methionine was associated with protracted reduction of seizures in a line of transgenic mice. Compar Med 58:604-606.
2008 Lee S, Chu B, Yao J, Shea TB and Hall GF. (2008) The glutamate-rich region of the larger lamprey neurofilament sidearm is essential for proper neurofilament architecture. Brain Res 1231:1-5.
2008 Chan A, Tchantchou F, Graves V, Rozen R and Shea TB (2008) Dietary and genetic compromise in folate availability reduces acetylcholine and cognitive performance: critical role of S-adenosylmethionine. J Health Nutr Aging 12:252-261.
2008 Chan A, Remington R and Shea TB (2008) The Clock-drawing test: Time for a change? Am J Alz Dis Other Dementias 23: 377-381.
2008 Chan A, Paskavitz J, Remington R and Shea TB (2008) Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: A one-year open-label pilot study with a 16-month extension. Am J Alz Dis Other Dementias 23: 571-585
2008 Chan A, Alsaraby A and Shea TB (2008) Folate deprivation increases tau phosphorylation by homocysteine-induced calcium influx and by inhibition of phosphatase activity: alleviation by S-adenosyl methionine. Brain Res 1199: 133-137.
2007 Shea TB and Beatty W (2007) Traffic jams: models for neurofilament accumulation in motor neuron disease. Traffic 8:445-447.
2007 Kuo F, Kotyla T, Wilson T, Kifle L, Panagiotou T, Gruverman I, Tagne J-B, Shea, TB and Nicolosi RJ (2007) A nanoemulsion of an anti-oxidant synergy formulation reduces tumor growth rate in neuroblastoma-bearing nude mice.  J Exp Ther Oncol 6: 129-135.
2007 Dubey M, Chaudhury P, Kabiru H and Shea TB (2007) Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: neurofilaments attenuate tau-mediated neurite stability.  Cell Motil Cytoskel 65: 89-99.
2007 Dubey M and Shea TB (2007) Potentiation of arsenic neurotoxicity by folate deprivation: protective role of S-adenosyl methionine. Nutr Neurosci. 10:199-204.
2007 DeFuria J and Shea TB  (2007) Arsenic inhibits neurofilament transport and induces perikaryal accumulation of phosphorylated neurofilaments:  Roles of JNK and GSK-3beta. Brain Res 1181:74-82
2007 Chan A and Shea TB (2007) Improved cognitive performance and decreased aggression in normal and ApoE4 mice following dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine. Neuromol Med 9:264-269.
2007 Chan A and Shea TB (2007) Folate deprivation increases presenilin expression, gamma-secretase activity and Abeta levels in murine brain: potentiation by Apoe deficiency and alleviation by dietary S-adenosyl methionine. J Neurochem: 102:753-760.
2006 Tchantchou F, Graves M, Ortiz D and Shea TB  (2006) S-adenosyl methionine: a link between nutritional and genetic risk factors in Alzheimer's disease. J Nutri Health Aging 10:541-544.
2006 Shea TB and Chan A (2006) Food for thought: Dietary influence on acetylcholine. J Alz dis 10:1-2.
2006 Shea TB (2006) Folate, homocysteine and Alzheimer's disease J Alz dis 9:359-360
2006 Motil J, Dubey M, Chan W K-H and Shea TB (2006) Inhibition of dynein but not kinesin induces focal accumulation of neurofilaments in axonal neurites. Brain Res 1164:125-131.
2006 Motil J, Chan W K-H, Dubey M, Chaudhury P, Pimenta A, Chylinski TM, Ortiz DT and Shea TB (2006) Dynein mediates retrograde neurofilament transport within axonal neurites and anterograde delivery of NFs from perikarya into axons: Regulation by multiple phosphorylation events.  Cell Motil Cytoskel 63: 266-286.
2006 DeFuria J, Chen P and Shea TB (2006) Divergent effects of the MEKK-1/JNK pathway on NB2a/d1 differentiation: some activity is required for neurite outgrowth and maturation but overactivation inhibits both phenomena. Brain Res 1123:20-26.
2006 Chan A, Graves V and Shea TB (2006). Apple juice concentrate maintains acetylcholine levels following dietary compromise. J Alz dis 9:287-291
2006 Chan A and Shea TB (2006) Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress. J Alz dis 10:353-358.
2006 Chan A and Shea TB (2006) Dietary and genetically-induced oxidative stress alter tau phosphorylation: influence of folate and apolipoprotein E deficiency. J Alz dis 9:399-405
2005 Tchantchou F, Graves M, Rogers E, Ortiz D and Shea TB  (2005) N-acetyl cysteine alleviates neurodegeneration and increased glutathione expression in normal and ApoE-deficient mice.  J Alz Dis 7:135-138
2005 Tchantchou F, Graves M, Rogers E, Ortiz D and Shea TB  (2005) Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: Relevance to age-related neurodegeneration.  Neuromol Med 6:93-104
2005 Tchantchou F, Graves M, Ortiz D and Shea TB (2005) Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: Modulation by apolipoprotein E-deficiency. Nutritional Neurosci 9:17-24.
2005 Tchantchou F, Chan A, Kifle L, Ortiz D and Shea TB  (2005) Apple juice concentrate prevents oxidative damage and cognitive decline in aged mice.  J Alz Dis 8: 283-287.
2005 Shea TB, Ortiz D, Nicolosi RJ, Kumar R and Watterson A (2005) Nanosphere-mediated delivery of vitamin E increases its efficacy against oxidative stress resulting from exposure to amyloid beta. J Alz Dis 7:297-301.
2005 Moran CM, Donnelly M, Daniela Ortiz D, Pant HC, Mandelkow E-M P and Shea TB (2005) Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen activated protein kinase activity. Mol Brain Res 134: 338-344.
2005 Linsley M-D, Ekinci FJ, Ortiz D, Rogers E and Shea TB (2005) Monitoring thiobarbituric acid-reactive substances (TBARs) as an assay for oxidative damage in neuronal cultures and central nervous system. J Neurosci Meth 141:219-222.
2005 Jung C, Lee S, Ortiz D, Zhu Q, Julien J-P and Shea TB (2006) Phosphorylation of the high molecular weight neurofilament subunit regulates the association of neurofilaments with kinesin in situ. Mol Brain Res: 141:151-5.
2005 Dhitavat S, Ortiz D, Rogers E, Rivera E and Shea TB (2005) Folate, vitamin E and acetyl-L-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid beta.  Brain Res 1061:114-117
2005 Chan W K-H, Yabe JT, Pimenta AF, Ortiz D and Shea TB (2005) Neurofilaments can undergo transport and cytoskeletal incorporation in a discontinuous manner Cell Motil Cytoskel 62: 166-179.