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Taras Lyubchenko

Taras Lyubchenko
Taras LyubchenkoAssociate Professor
  • CollegeZuckerberg College of Health Sciences
  • DepartmentBiomedical & Nutritional Sciences
  • EmailTaras_Lyubchenko@uml.edu

Research Interests

Lymphocyte activation, antigen receptor signal transduction, Ca2+ signaling. Complement-mediated B cell activation in inflammatory autoimmune diseases (Rheumatoid arthritis, Lupus). Bioinformatics and computational approaches to the modeling of signal transduction processes. Signaling-based biomarkers for autoreactive lymphocytes and identification of signal transduction targets for pharmacological interference to prevent autoimmune activation.

Biography

Taras Lyubchenko’s scientific interests are in areas of Immunology, Autoimmunity, Cell Biology and Signal Transduction. His research programs have been focused on T and B lymphocyte activation and antigen receptor signal transduction mechanisms, complement-mediated B cell activation in inflammatory autoimmune diseases (Rheumatoid arthritis, Lupus), bioinformatics and computational approaches to the modeling of signal transduction processes, development of signaling-based biomarkers for autoreactive lymphocytes and identification of signal transduction targets for pharmacological interference to prevent autoimmune activation. He leads NIH-funded immunological clinical and translational studies in human subjects and animal models that utilize cutting edge cell signaling research methods: advanced fluorescent microscopy, 3-dimensional imaging of the immune synapse, 2-photon and FRET imaging, membrane receptor/ligand trafficking with TIRF, ratiometric Ca2+ imaging, 8-12 color FACS analysis of rare cell subsets, Phosflow, PAGE protein phosphorylation analysis and proteomics arrays.

Selected Publications

  • Lapel, M., Weston, P., Strassheim, D., Karoor, V., Burns, N., Lyubchenko, T., Paucek, P., Stenmark, K.R., Gerasimovskaya, E.V. (2017) "Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells.," American Journal of Physiology: Cell Physiology 312:1 pp. C56 - C70
  • Lapel, M., Weston, P., Strassheim, D., Karoor, V., Burns, N., Lyubchenko, T., Paucek, P., Stenmark, K.R., Gerasimovskaya, E.V. (2016) "Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells.," American Journal Of Physiology. Cell Physiology pp. ajpcell.00250.2016
  • Lyubchenko, T., Zerbe, G.O. (2014) "B cell receptor signaling-based index as a biomarker for the loss of peripheral immune tolerance in autoreactive B cells in rheumatoid arthritis.," Plos One 9:7 pp. e102128
  • Liubchenko, G.A., Appleberry, H.C., Striebich, C.C., Franklin, K.E., Derber, L.A., Holers, V.M., Lyubchenko, T. (2013) "Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes.," Journal Of Autoimmunity 40: pp. 111 - 121
  • Amura, C.R., Renner, B., Lyubchenko, T., Faubel, S., Simonian, P.L., Thurman, J.M. (2012) "Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion.," Molecular Immunology 52:3-4 pp. 249 - 257
  • Liubchenko, G.A., Appleberry, H.C., Holers, V.M., Banda, N.K., Willis, Van C, ., Lyubchenko, T. (2012) "Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile.," Journal Of Autoimmunity 38:4 pp. 293 - 303
  • Lyubchenko, T., Woodward, H., Veo, K.D., Burns, N., Nijmeh, H., Liubchenko, G.A., Stenmark, K.R., Gerasimovskaya, E.V. (2011) "P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.," American Journal Of Physiology. Cell Physiology 300:2 pp. C266 - C275
  • Lyubchenko, T. (2010) "Ca²+ signaling in B cells.," The scientific world journal 10: pp. 2254 - 2264
  • Lyubchenko, T., Liubchenko, G., Holers, V.M. (2010) "Characterization of intracellular signaling profiles induced by antigen receptor activation in murine B cell subsets (132.30)," The Journal of Immunology 184:1 Supplement pp. 132–30
  • Lyubchenko, T., Nielsen, J.P., Miller, S.M., Liubchenko, G.A., Holers, V.M. (2009) "Role of initial protein phosphorylation events and localized release-activated calcium influx in B cell antigen receptor signaling.," Journal Of Leukocyte Biology 85:2 pp. 298 - 309
  • Lyubchenko, T., Miller, S., Liubchenko, G., Holers, M. (2008) "P156: Complement receptor 2/B cell receptor co-ligation induces extracellular Ca2+ influx via highly selective Ca2+ release-activated channels (CRAC) regulated by stromal interaction molecule 1 (STIM1).," Molecular Immunology 45:ICW Basel pp. 4147
  • Lyubchenko, T., Dal Porto, J., Holers, V.M., Cambier, J.C. (2007) "145: Complement C3dg-enhanced antigen breaks B cell anergy in Ars/A1 murine model.," Molecular Immunology 44:XXI International Complement Workshop Beijing, China, October 22-26, 2006 pp. 211
  • Kulik, L., Marchbank, K.J., Lyubchenko, T., Kuhn, K.A., Liubchenko, G.A., Haluszczak, C., Gibson, M.G., Boackle, S.A., Holers, V.M., Breloer, M., others, . (2007) "Cellular immune response," Eur. J. Immunol 37: pp. 579–582
  • Kulik, L., Marchbank, K.J., Lyubchenko, T., Kuhn, K.A., Liubchenko, G.A., Haluszczak, C., Gipson, M.G., Boackle, S.A., Holers, V.M. (2007) "Correction: Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development.," European Journal of Immunology 37:4 pp. 1149
  • Lyubchenko, T., Dal Porto, J.M., Holers, V.M., Cambier, J.C. (2007) "Cutting edge: Complement (C3d)-linked antigens break B cell anergy.," Journal Of Immunology (Baltimore, Md.: 1950) 179:5 pp. 2695 - 2699
  • Kulik, L., Marchbank, K.J., Lyubchenko, T., Kuhn, K.A., Liubchenko, G.A., Haluszczak, C., Gipson, M.G., Boackle, S.A., Holers, V.M. (2007) "Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development.," European Journal Of Immunology 37:3 pp. 623 - 633
  • Lyubchenko, T., dal Porto, J., Cambier, J.C., Holers, V.M. (2005) "Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway.," Journal Of Immunology (Baltimore, Md.: 1950) 174:6 pp. 3264 - 3272
  • Lyubchenko, T., Wurth, G.A., Zweifach, A. (2003) "The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis-dependent target cell killing.," The Journal Of Physiology 547:Pt 3 pp. 835 - 847
  • Lyubchenko, T., Wurth, G.A., Zweifach, A. (2001) "Article: Role of Calcium Influx in Cytotoxic T Lymphocyte Lytic Granule Exocytosis during Target Cell Killing.," Immunity 15: pp. 847 - 859
  • Holeva, O., Paster, I., Lyubchenko, T., Paster, I., Kholodna, L., Zamotaierva, H., Hrodzins’ kyi, D. (2000) "Fiziolohichnyi zhurnal (Kiev, Ukraine: 1994),"
  • Kholodna, L., Holeva, O., Lyubchenko, T., Kucherenko, M. (1999) "Mitohenna dia antyhennykh substantsii stafilokoka na limfotsyty oprominenykh shchuriv linii vistar.," Ukrain’skyi Biokhimichnyi Zhurnal 71:5 pp. 65–68
  • Kholodna, L., Holeva, O., Lyubchenko, T., Korzhyk, N., Holev, G. (1999) "Rol’mikroorhanizmiv rany u vynyknenni pisliaoperatsiinykh uskladnen’.," Klinicheskaya Khirurgiya 8 pp. 25–27
  • Lyubchenko, T., Holeva, O., Kholodna, L., Smirnov, V., Vershyhora, A. (1997) "Biolohichna aktyvnist’faktora perenosu, indukovanoho bakterial’nymy antyhenamy.," Mikrobiolohichnyi zhurnal (Kiev, Ukraine: 1993) 59:5 pp. 83–100
  • Lyubchenko, T., Holeva, O., Kholodna, L., Stepanchuk, V., Vershyhora, A. (1997) "Liuds’ kyi spetsyfichnyi Faktor perenosu do antyheniv Staphylococcus aureus.,"
  • Holieva, O., Lyubchenko, T., Kholodna, L., Vershihora, A. (1996) "Oderzhannia faktora perenosu hiperchutlyvosti spovil’nenoho typu mors’ kykh svynok do antyhennykh substantsii Staphylococcus aureus.,"