Publications

Selected Publications 1999-present.  Links are to pdfs.  Most recent papers are often uncorrected proofs or preprints.

  • Jung C, Lee S, Ortiz D, Zhu Q, Julien J-P and Shea TB (2006) Phosphorlation of the high molecular weight neurofilament subunit regulates the association of neurofilaments with kinesin in situ. Mol Brain Res: in press.
  • Chan W K-H, Yabe JT, Pimenta AF, Ortiz D and Shea TB (2005) Neurofilaments can undergo transport and cytoskeletal incorporation in a discontinuous manner Cell Motil Cytoskel: in press.
  • Tchantchou F, Chan A, Kifle L, Ortiz D and Shea TB  Apple juice concentrate prevents oxidative damage and cognitive decline in aged mice. J Alz Dis: in press.
  • Tchantchou F, Graves M, Ortiz D and Shea TB  (2005) S-adenosyl methionine: a link between nutritional and genetic risk factors in Alzheimers disease. J Nutri Health Aging: in press.
  • Dhitavat S, Ortiz D, Rogers E, Rivera E and Shea TB (2005) Folate, vitamin E and acetyl-L-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid beta.  Brain Res: in press.
  • Shea TB, Ortiz D, Nicolosi RJ, Kumar R and Watterson A (2005) Nanosphere-mediated delivery of vitamin E increases its efficacy against oxidative stress resulting from exposure to amyloid beta. J Alz Dis: in press.
  • Tchantchou F, Graves M, Rogers E, Ortiz D and Shea TB  (2005) N-acetyl cysteine alleviates neurodegeneration and increased glutathione expression in normal and ApoE-deficient mice.  J Alz Dis 7: 135-138.
  • Tchantchou F, Graves M, Rogers E, Ortiz D and Shea TB  (2005) Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency: Differential compensatory responses of normal and apolipoprotein E-deficient mice.  Neuromol Med: in press.
  • Tchantchou F, Graves M, Ortiz D, Rogers E and Shea TB (2004) Dietary supplementation with apple juice eliminates the compensatory increase in glutathione synthase transcription and activity in normal and genetically-compromised mice. J Nut Health Aging: 8(6):492-6.
  • Tchantchou F, Graves M, Rogers E, Ortiz D and Shea TB  (2005) Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: Relevance to age-related neurodegeneration. Neuromol Med 6:93-104.
  • Jung C, Chylinski T, Yabe JT, Pimenta A, Ortiz D and Shea TB (2004) Myosin regulates neurofilament axonal transport and distribution. J Neurosci; 24(43):9486-96.
  • Chan W K-C, Dickerson A, Otriz D, Pimenta A, Moran C, Malik K, Motil J, Snyder S, Pant HC and Shea TB (2004). Mitogen activated protein kinase regulates neurofilament axonal transport. J Cell Sci;117(Pt 20):4629-42.
  • Dubey M, Hoda S, Chan WK-H, Pimenta A, Ortiz D and Shea TB (2004) Re-expression of vimentin in differentiated neuroblastoma cells enhances elongation of axonal neurites J Neurosci Res:15;78(2):245-9
  • Rogers, EJ, Mihalick S, Ortiz D and Shea TB (2004) Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice. J Nutr Health Aging 8:92-97.
  • Ortiz D and Shea TB (2004) Apple juice prevents oxidative stress induced by amyloid-beta in culture. J Alz Dis 6:27-30.
  • Tjiattas L, Ortiz D, Sirikarnt Dhivant S, Mitton K, Rogers E and Shea TB (2004) Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell 3:71-76.
  • Shea TB, Zheng Y-L, Ortiz D, and Pant HC (2004) Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress: J Neurosci Res 76:795-800.
  • Linsley M-D, Ekinci FJ, Ortiz D, Rogers E and Shea TB (2004) Monitoring thiobarbituric acid-reactive substances (TBARs) as an assay for oxidative damage in neuronal cultures and central nervous system. J Neurosci Meth 141:219-222.
  • Shea TB, Ortiz D and Rogers E (2004) Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation. J Alz Dis 6:269-273.
  • Shea TB, Milner A, Ortiz D, Mihalick S, Ashline D and Rogers E (2004) The S-adenosyl homocysteine hydrolase inhibitor, 3-deaza adenosine, prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration. Neuromol Med 5:171-180.
  • Mihalick SM, Ortiz D, Kumar R, Rogers E and Shea TB (2004) Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E. Neuromol Med 4:197-202.
  • Jung CJ and Shea TB (2004) Neurofilament subunits undergo more rapid translocation within retinas than in optic axons. Mol Brain Res 122:188-192.
  • Tchantchou F, Graves M, Ashline D, Morin A, Pimenta A, Ortiz D, Rogers E and Shea TB (2004) Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E and apolipoprotein E. J Neurosci Res: 75(4):508-155.
  • Shea TB, Yabe, JT, Ortiz D, Pimenta A, Loomis P, Goldman RD, Amin N and Pant HC (2004) CDK5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons. J Cell Sci 117:933-941.
  • Mattson MM and Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci: 26:137-146.
  • Shea TB, Jung C and Pant HC (2003). Does C-terminal phosphorylation regulate neurofilament transport?  Re-evaluation of recent data suggests that it does. Trends Neurosci 26:397-400.
  • Shea, TB, Ekinci F, Ortiz D, Wilson T and Nicolosi R (2003) Efficacy of vitamin E, phosphatidyl choline and pyruvate on amyloid-beta neurotoxicity. J Health Nutri Aging 7:252-255.
  • Yabe, JT, Chan W K-H, Wang F-S, Pimenta A, Ortiz D, and Shea TB (2003) Regulation of the transition from vimentin to neurofilaments during neuronal differentiation. Cell Motil Cytoskel 56: 193-205.
  • Ho P, Ashline D, Dhitavat S, Ortiz D, Collins SC, Rogers E and Shea, TB (2003) Folate deprivation induces neurodegeneration: Roles of oxidative stress and increased homocysteine. Neurobiol Dis 14:32-42.
  • Shea TB, Ortiz D, Sheu M-S (2003) Quantification of antioxidant activity in brain tissue homogenates using the "total equivalent antioxidant capacity" assay J Neurosci Meth 125: 55-58.
  • Shea TB, Rogers E, Ortiz D and Sheu M-S (2002) Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Rad Biol Med: 33:1115-1120.
  • Chan W K-H, Yabe JT, Pimenta AF and Shea TB (2002) Growth cones contain a highly-dynamic population of neurofilament subunits. Cell Motil Cytoskel 54:195-207.
  • Ho PI, Ortiz D, Rogers E and Shea TB (2002) Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J Neurosci Res 70:694-702.
  • Dhitavat S, Daniela Ortiz, D, Shea TB and Rivera ER (2002) Acetyl-L-Carnitine protects against Amyloid-beta neurotoxicity: Roles of oxidative buffering and ATP levels. Neurochem Res 27:501-505.
  • Shea TB, Ekinci FJ, Ortiz D, Dawn-Linsely M, Wilson TO and Nicolosi RJ (2002) Efficacy of vitamin E, phosphatidyl choline and pyruvate on buffering neuronal degeneration and oxidative stress in cultured cortical neurons and central nervous tissue of apolipoprotein E-deficient mice. Free Rad Biol Med: 33:276-282.
  • Shea TB, Lyons-Weiler J and Rogers E (2002) Homocysteine, folate and Alzheimer's neuropathology. J Alz Dis 4:261-267.
  • Shea TB and Rogers E (2002) Homocysteine as a risk factor for Alzheimer's disease. New Eng J Med: June 20, 2002.
  • Shea TB and Rogers E (2002) Folate quenches oxidative damage in brains of apolipoprotein E-deficient mice: augmentation by vitamin E. Molecular Brain Res 108:1-6.
  • Shea TB and Flanagan L (2001) Kinesin, dynein and neurofilament transport. Trends in Neurosciences 24:644-648.
  • Yabe JT, Chan W K-H, Chylinski TM, Wang F-S, Kattar S, Linsley M-D, Pimenta AF and Shea TB (2001) Neurofilaments consist of distinct populations that can be distinguished by C-teriminal phosphorylation, bundling and axonal transport rate in growing axonal neurites.  J Neurosci: 21:2195-2205.
  • Yabe JT, Wang F-S, Chylinski T, Katchmar T and Shea TB (2001) Selective accumulation of the high molecular weight neurofilament subunit within the distal region of growing axonal neurites. Cell Motil Cytoskel: 50:1-12.
  • Dhitavat S, Rivera E, Rogers E and Shea TB (2001) Differential efficacy of lipophilic and cytosolic antioxidants on generation of reactive oxygen species by amyloid-beta J Alz Dis 3: 525-529.
  • Ho PI, Dhivant S, Ashline D, Ortiz D, Rogers E and Shea TB (2001) Homocysteine potentiates amyloid-beta neurotoxicity; Role of oxidative stress. J Neurochem 78:1-6.
  • Yabe JT, Chan W K-H, Chylinski TM, Lee S, Pimenta AF and Shea TB (2001) The predominant form in which neurofilament subunits undergo axonal transport differs during axonal initiation, outgrowth and maturation. Cell Motil Cytoskel 48:61-83.
  • Shea TB and Yabe JT (2000) Occam's razor slices through the mysteries of axonal transport: Can it really be so simple? Traffic 1:522-523.
  • Yabe JT, Chan W K-H and Shea TB (2000) Phospho-dependent interactions of neurofilament proteins with kinesin in situ. Cell Motil Cytoskel 45:249-262.
  • Ekinci FJ, Linsley M-D and Shea TB (2000) Beta-amyloid induces apoptosis by oxidative stress rather than tau hyperphosphorylation. Brain Res 76:389-395.
  • Jung C, Yabe JT and Shea TB (2000) C-terminal phosphorylation of the high molecular weight neurofilament protein regulates neurofilament axonal transport. Brain Res 856:12-19.
  • Yabe JY, Pimenta A and Shea TB (1999) Kinesin-mediated transport of neurofilament protein oligomers in growing axons. J Cell Sci 112:3799-3814.
  • Ma D-L, Himes TB, Shea TB and Fischer I (1999) Axonal transport of microtubule-associated protein 1B in sciatic nerve of adult rat: Distinct transport rates for different isoforms. J Neurosci 20:2112-2120.
  • Shea TB and Beermann ML (1999) The neuronal intermediate filament protein a-internexin facilitates axonal neurite elongation in neuroblastoma cells.  Cell Motil Cytoskel: 43:322-333.
  • Jung C, Yabe JT and Shea TB (1999) Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ.  Cell Motil Cytoskel 42:230-240.
  • Ekinci FJ, Malik K and Shea TB (1999) Activation of the L voltage-sensitive calcium channel by MAP kinase following exposure of neuronal cells to beta-amyloid: MAP kinase mediates beta-amyloid-induced neurodegeneration.  J Biol Chem 274:30322-30327. 

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