Peter Gaines

Assistant Professor

Expertise:

Molecular and Developmental Biology

Phone: (978)934-2883

B.S., Biology, University of Vermont, 1985
Ph.D., Molecular Genetics, Yale University, 1996

Research in my laboratory is focused on analyzing the molecular signaling pathways that control blood cell differentiation. We are specifically interested in the development of the neutrophil, a phagocyte that plays a critical role in innate immunity. Neutrophil maturation occurs in the bone marrow, where pluripotent stem cells differentiate in response to cytokines released from sites of acute infection or inflammation. Importantly, disruption of neutrophil differentiation not only compromises immune responses but also underlies the pathogenesis of myelogenous leukemias. Using blood progenitor cell lines that can be induced to undergo maturation towards fully functional neutrophils, we are elucidating the molecular mechanisms that control neutrophil differentiation and functional activation using a combination of cell culture, molecular biology and biochemistry.



Peter Gaines Assistant Professor Expertise: Molecular and Developmental Biology Phone: (978)934-2883 Email: Peter_Gaines@uml.edu Educational Background B.S., Biology, University of Vermont, 1985 Ph.D., Molecular Genetics, Yale University, 1996 Scholarly Interests Research in my laboratory is focused on analyzing the molecular signaling pathways that control blood cell differentiation. We are specifically interested in the development of the neutrophil, a phagocyte that plays a critical role in innate immunity. Neutrophil maturation occurs in the bone marrow, where pluripotent stem cells differentiate in response to cytokines released from sites of acute infection or inflammation. Importantly, disruption of neutrophil differentiation not only compromises immune responses but also underlies the pathogenesis of myelogenous leukemias. Using blood progenitor cell lines that can be induced to undergo maturation towards fully functional neutrophils, we are elucidating the molecular mechanisms that control neutrophil differentiation and functional activation using a combination of cell culture, molecular biology and biochemistry.

Department of Biological Sciences - Olsen Hall (UML North), 1 University Avenue, Lowell, MA 01854 Phone: 978-934-2860 Fax: 978-934-3044 Contact us