Case Studies

Purification Process Characterization
Case study to be provided soon.

 

E. COLI Fermentation Development 

E. coli is the organism of choice for nonglycosylated recombinant protein production.  Proteins can be expressed as inclusion bodies, intracellular soluble protein or periplasmic secreted proteins.  E. coli has many advantages for use as a production host.

         

FEATURE

PROCESS BENEFIT

 

 

Simple nutritional requirements

 

Fast growth rate

 

High cell density

 

Expression as inclusion body

 

Expression as soluble product

(intracellular or periplasmic)

 

Absence of human or related viruses

Low media cost

 

High throughput

 

High productivity

 

Protease stable

 

No refolding required

 

 

Simplified validations


Fermentation Development

  • Intracellular soluble
  • Periplasmic secreted

Massachusetts BioManufacturing Center (MBMC) - UML North, 1 University Avenue, Lowell, MA 01854
Phone: 978-934-3158 Fax: 978-934-3047 Contact Us