Clinical Laboratory Instrumentation

This course is designed to provide an in-depth knowledge of clinical chemistry laboratory instrumentation. Emphasis is placed on theoretical concepts, instrument components and design, calibration and troubleshooting of modern instrumentation, and analytical methodologies in the clinical laboratory. Additionally, qualitative and quantitative applications of instrumental techniques are covered. Computer applications are included where appropriate. The following spectroscopic instruments are studied: ultraviolet, visible and infra red absorption, fluorescence, turbidimetry and nephelometry, reflectance, flame emission and atomic absorption spectroscopy. Electrochemical methods of analysis are reviewed, including potentiometric techniques, voltammetry and coulometry. Chromatographic instrumentation and methods are discussed, such as column and thin layer chromatography, high pressure liquid chromatography, gas chromatography, and ion exchange chromatography.