BioManufacturing Center

Applied Research

The MBMC focuses on applied research problems that will improve the quality, cost and productivity of large-scale biomanufacturing production.  Applied research pursues both incremental and breakthrough advances.

Incremental advances include improved process control of bioreactors, increased expression levels, prolonged cell lifetimes, accelerated cell growth rates (cell cycle times) and higher product quality, as well as novel and disposable purification technologies.

Breakthrough programs include perfusion reactors to convert from batch to continuous processes, developing yeast as a replacement for mammalian cell cultures and using E. coli to produce antibodies in soluble form.   Initial adaptation of our applied research may potentially provide considerable economical advantages for a biopharmaceutical manufacturing operation.