Professor Terence Flotte
Professor Flotte earned his M.D. at the Louisiana State University School of Medicine in New Orleans and completed his residency and postdoctoral training at Johns Hopkins Hospital. He taught at Johns Hopkins and at the University of Florida before joining UMMS. He currently serves as the Dean, Provost and Executive Deputy Chancellor of UMass Medical School, and is the Celia and Isaac Haidak Distinguished Professor. An internationally known pioneer in human gene therapy, he is currently investigating the use of gene therapy for genetic diseases that affect children, including cystic fibrosis, alpha-1 antitrypsin (AAT) deficiency, type I diabetes, and disorders of fatty acid oxidation. He is conducting Phase I trials with rAAV expressing alpha-1antitrypsin in AAT-deficient patients. He has also focused on the study of adeno-associated virus (AAV) vectors. His laboratory has also investigated the mechanisms of AAV persistence, since these represent the basis for a more profound understanding of the potential for long-term safe and effective gene therapy.
Associate Professor Deborah Molrine
Associate Professor Molrine earned an M.D. at the University of Pennsylvania School of Medicine and an MPH at the Johns Hopkins University School of Hygiene and Public Health. She completed a pediatric residency at Johns Hopkins and an infectious diseases fellowship at Children's Hospital in Boston. She taught at Harvard Medical School before joining UMMS. She currently serves as the Deputy Director of Clinical and Regulatory Affairs for MassBiologics at UMMS. Her research interests focus on clinical development of investigational new drug products, including human monoclonal antibodies to C. difficile toxins A and B, hepatitis C virus, and rabies.